Clinical trials: Endoscopy
Sinusitis
Rates of Middle Meatus Synechiae Formation Post ESS
The study is designed to evaluate if addition of the steroid to the spacer / stent will improve healing after endoscopic sinus surgery (ESS) compared to spacer without drug.
- Trial name
- NCT03036735
- Testing
- steroid eluting spacer
- Volunteers
- 10 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Esophageal Cancer
Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800CW
Radiation and chemotherapy can shrink the tumor. For certain types of cancer, immunotherapy is added to further reduce the tumor size.
- Trial name
- GLOW (NCT07196384)
- Testing
- Spectroscopy system, Nivolumab-800CW, Durvalumab-680LT
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Controlled Hypotension for Nasal Surgeries
Comparison of Two Sedative Agents in Terms of Controlled Hypotension
Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention.
- Trial name
- NCT07460050
- Testing
- Propofol, Isoflurane
- Where
- Pakistan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Aspiration Pneumonias, Tube Feeding
Percutaneous Endoscopic Gastrostomy Versus Percutaneous Endoscopic Gastrostomy With Jejunal Extension
The goal of this clinical trial is to learn if placing a feeding tube with a small bowel extension (called Percutaneous Endoscopic Gastrostomy With Jejunal Extension [PEG-J]) is better at preventing pneumonia than a standard…
- Conditions
- Aspiration Pneumonias, Tube Feeding, Enteral Feeds
- Trial name
- NCT06717321
- Testing
- (Arm 1): PEG, (Arm 2): PEG-J
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Jerry Dang
Obesity
Clinic-based Nasopharyngoesophagogastroscopy Following Bariatric Surgery
This study aims to determine that this new technology, nasopharyngoendoscopy, is just as effective in diagnosing problems as the current gold standard.
- Trial name
- EGScan (NCT01602991)
- Testing
- clinic-based nasopharyngoendoscopy, Standard Endoscopy
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dennis Hong MD
Chronic Sinusitis, Nasal Polyposis
FESS With or Without Intranasal Desmopressin in Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps is a condition that causes long-lasting inflammation and swelling in the nose and sinuses and may lead to nasal blockage, nasal discharge, facial pressure, and reduced sense of smell.
- Trial name
- NCT07855315
- Testing
- Desmopressin Acetate Nasal, 10 μg/0.1 ml per spray, Functional Endoscopic Sinus Surgery
- Volunteers
- 174 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pancreatitis,Acute Necrotizing
Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis
This is a randomized trial comparing immediate endoscopic necrosectomy vs. step-up endoscopic interventions in patients with necrotizing pancreatitis.
- Trial name
- DESTIN (NCT05043415)
- Testing
- Immediate endoscopic necrosectomy, Step-up endoscopic interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Orlando Health, Inc.
LRG Levels
Effectiveness of Serum Leucine-rich Alpha-2 Glycoprotein Levels on IBD
We attempt to examine the association between serum leucine-rich alpha-2 glycoprotein (LRG) levels and endoscopic activity in patients with possible ulcerative colitis (UC) or Crohn's disease (CD) to determine whether LRG was a…
- Trial name
- NCT04535882
- Testing
- serum leucine-rich alpha-2 glycoprotein (LRG) levels
- Where
- Japan
- Volunteers
- 673 people
- Sponsor
- Showa Inan General Hospital
Obese
Safety and Preliminary Effectiveness of the BaroSense Articulating Circular Endoscopic (ACE) Stapler for Plication of Dilated Post-surgical Gastric Anatomy
The BaroSense Articulating Circular Endoscopic (ACE) Stapler is an investigational instrument indicated for endoluminal trans-oral tissue approximation and ligation in the gastrointestinal tract.
- Trial name
- NCT01388673
- Testing
- BaroSense ACE Stapler for plication of dilated post-surgical gastric anatomy
- Sponsor
- BaroSense Inc.
Obese Patients, Tobacco Use
Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux
The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population.
- Conditions
- Obese Patients, Tobacco Use, Veterans, Family History of Esophageal Cancer
- Trial name
- NCT06746623
- Testing
- Enrolled participants will complete Esocheck/Esoguard and diagnostic upper endoscopy.
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Louis Stokes VA Medical Center
The Impact of Vaping on Crohn's Disease Endoscopic Recurrence After Resection
Effects of Vaping on Post-operative Recurrence of Crohn's Disease
Tobacco smoke is a well-established risk factor for post-operative recurrence of Crohn's disease. Over the last few decades electronic cigarettes have gained popularity as an alternative to traditional tobacco, however, their…
- Trial name
- VAPE-CD (NCT06734780)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Ospedale San Raffaele
Pancreatic Tumor, Fine Needle Aspiration
Comparison of Two Needles (ProCore vs EchoTip) for the Diagnosis of Pancreatic Solid Mass Under EUS
The negative predictive value of fine needle aspiration under ultrasound endoscopy (EUS) for the diagnostic of solid pancreatic masses is 70% on average in the current literature with 22 gauge needles.
- Conditions
- Pancreatic Tumor, Fine Needle Aspiration, Endoscopic Ultrasonography
- Trial name
- PICORE (NCT01479803)
- Testing
- Puncture with fine needle aspiration under endoscopic ultrasonographic control
- Where
- France
- Volunteers
- 80 people
- Sponsor
- VANBIERVLIET
Sleep Apnea, Obstructive
Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep
This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is…
- Trial name
- Nasal vs Oral (NCT06789770)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Carpal Tunnel
Short- to Medium-term Outcome of Minimally Invasive Carpal Tunnel Release
The aim of the study is to determine whether minimally invasive, ultrasound-guided thread carpal tunnel release leads to faster functional recovery compared to standard open and endoscopic techniques in patients with carpal…
- Trial name
- NCT06997172
- Testing
- TCTR (thread carpal tunnel release), Standard-of-care
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- University Hospital, Basel, Switzerland
Solid Pancreatic Neoplasms, Endoscopic Ultrasound
Non-hypovascular Solid Pancreatic Lesions: Role of EUS
Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS).
- Trial name
- LE-VASC (NCT03738280)
- Testing
- Endoscopic ultrasound-fine needle biopsy
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Colon Polyp
The Colon Endoscopic Bubble Scale (CEBuS); Validation Study
Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority.
- Trial name
- CEBuS (NCT04378088)
- Testing
- Validation of CEBuS
- Where
- Portugal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Rectal Neoplasms, Neuroendocrine Tumors
Clinical Relevance of the Salvage Treatment for Colorectal Neuroendocrine Tumors
we evaluated all related clinical and pathologic data of rectal NET cases, including the resection margin status, NET grading, and lymphovascular invasion status.
- Trial name
- NCT06143605
- Testing
- salvage treatment
- Volunteers
- 527 people
- Sponsor
- Yanhong Deng
VR, Virtual Reality Pain Distraction
Virtual Reality to Improve Patient Experience During Endoscopic Mucosal and Submucosal Resection
This study explores the feasibility of using Virtual Reality (VR) to manage pain and anxiety during Endoscopic Mucosal (EMR) and Submucosal Dissection (ESD).
- Conditions
- VR, Virtual Reality Pain Distraction, Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection
- Trial name
- VREMRESD (NCT06766162)
- Testing
- Virtual reality pain distraction, Standard analgesia and sedation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College Hospital NHS Trust
Solid Pancreatic Tumor
Endoscopic Ultrasound (EUS)-Guided Fine Needle Aspiration (FNA) With Rapid On-site Evaluation (ROSE) of Cytopathology vs. EUS-guided Fine Needle Biopsy (FNB) Alone in the Diagnosis of Pancreatic Solid Lesions
Currently, the best way to evaluate pancreatic masses is through endoscopic-guided needle sampling of the mass to determine the diagnosis by looking at the acquired tissue under a microscope.
- Trial name
- NCT03435588
- Testing
- EUS, FNA with ROSE, FNB alone
- Where
- 6 sites in Canada
- Volunteers
- 235 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Supraglottic Airway Efficiency, Airway Complication of Anesthesia
LMA® Gastro Airway Versus Gastro-Laryngeal Tube in Endoscopic Retrograde Cholangiopancreatography
Comparison of second generation supraglottic airway devices about anesthesiologist, endoscopist and patient, which used for gastrointestinal procedures.
- Conditions
- Supraglottic Airway Efficiency, Airway Complication of Anesthesia, Airway Aspiration, Complication of Anesthesia
- Trial name
- NCT04196582
- Testing
- Comparison of LMA Gastro Airway® and Gastro-Laryngeal Tube in patients who will undergo biliopancreatic procedures.
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bezmialem Vakif University