Clinical trials: Endoscopic Ultrasound-Guided Radiofrequency Ablation
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Pancreatic Cancer, Endoscopic Ultrasound
Ex-vivo Ultrasound Guided Radiofrequency Ablation on Pancreatic Solid Lesions
The study investigates the feasibility and the efficacy to treat pancreatic solid lesions as pancreatic adenocarcinomas (PDAC) and neuroendocrine tumors (NET) with ex-vivo radiofrequency ablation (RFA) under ultrasound (US)…
- Conditions
- Pancreatic Cancer, Endoscopic Ultrasound, Radiofrequency Ablation
- Trial name
- NCT06371716
- Testing
- ex-vivo RFA under US control at 10 Watts (W) of power in 3 differents arms of lesions, ex-vivo RFA under US control at 30 Watts (W) of power in 3 differents arms of lesions, ex-vivo RFA under US control at 50 Watts (W) of power in 3 differents arms of lesions
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele
Treatment Related Cancer
Pancreatic Cyst Ablation With a Monopolar Radiofrequency Ablation Probe
Pancreatic cysts (A cyst is a thin walled cavity containing fluid) were rarely reported previously, but have been on a rise due to advanced imaging for evaluating pancreatic lesions or other medical reasons has increased…
- Trial name
- NCT04253249
- Where
- United States
- Sponsor
- Baylor College of Medicine
Cancer of Pancreas, Pancreatic Neoplasms
EUS-Coeliac Plexus Block Versus Radiofrequency Ablation in Pain Relief of Patients With Malignancy
Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive…
- Conditions
- Cancer of Pancreas, Pancreatic Neoplasms, Pain, Cancer-Associated Pain
- Trial name
- NCT04809935
- Testing
- 98% dehydrated alcohol, 19G EUSRA needle, Taewoong Medical, Korea
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Pancreatic Adenocarcinoma
Pilot Study of EUS-Guided Radiofrequency and FOLFIRINOX in Advanced Pancreatic Cancer (RadioFAP )
Pancreatic adenocarcinoma (PDAC) constitutes 90% of pancreatic tumors and is projected to become the second leading cause of cancer-related mortality in Europe by 2030.
- Trial name
- RadioFAP (NCT06743386)
- Testing
- Therapeutic procedure combines EUS-Guided Radiofrequency Ablation (RFA)
- Volunteers
- 30 people
- Sponsor
- French Society of Digestive Endoscopy
Pancreatic Neuroendocrine Tumors, WHO Grade I-II
Endoscopic Ultrasound Guided Radio Frequency Ablation of Pancreatic Neuroendocrine Neoplasms
A national multicenter prospective study to investigate the feasibility and efficacy of endoscopic ultrasound guided radiofrequency ablation of neuroendocrine pancreatic tumors, WHO Grade 1-2 of 3 cm or less in diameter.
- Trial name
- ERFA-PNET (NCT05243082)
- Testing
- Radio frequency ablation
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pancreatic Neoplasm
Evaluation of Endoscopic Ultrasound-Guided Radiofrequency Ablation for the Management of Pancreatic Tumors, ERASE Study
This clinical trial evaluates the safety and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for the management of patients with pancreatic tumors (including cysts) performed during recommended…
- Trial name
- ERASE (NCT05961982)
- Testing
- Chemical Ablation, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Malignancy, Pain Management
Endoscopic Ultrasound Guided Coeliac Plexus Neurolysis for Cancer Pain
Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive…
- Trial name
- NCT04801082
- Testing
- Alcohol injection, Radiofrequency Ablation
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Neuroendocrine Tumors, Neuroendocrine Carcinoma
Endoscopic Ultrasound-guided RadioFrequency Ablation for the Treatment Pancreatic NeuroEndocrine Neoplasms
This study evaluates the possibility and the safety of performing local therapy for Pancreatic neuroendocrine neoplasms (PanNENs) using radiofrequency ablation of the tumor under ultrasonography (EUS) guidance.
- Conditions
- Neuroendocrine Tumors, Neuroendocrine Carcinoma, Pancreas Neoplasm, Neuroendocrine Tumor Gastrointestinal, Hormone-Secreting
- Trial name
- RAPNEN (NCT03834701)
- Testing
- EUS guided radiofrequency ablation
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Pancreatic Insulinoma
EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT)
The goal of this muticentre randomized controlled trial is to compare endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with surgery for treatment of pancreatic insulinoma.
- Trial name
- ERASIN-RCT (NCT05735912)
- Testing
- Endoscopic ultrasound-guided radio frequency ablation, Surgery
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Carcinoma Metastatic, Pancreatic Adenocarcinoma
Trial Comparing EUS-guided Radiofrequency Ablation vs. EUS-guided Celiac Plexus Neurolysis
Pancreatic cancer is the second most common gastrointestinal malignancy. Abdominal discomfort is a main symptom in patients with pancreatic cancer. Approximately 75% have pain at diagnosis and over 90% in advanced stages.
- Conditions
- Pancreatic Carcinoma Metastatic, Pancreatic Adenocarcinoma, Pancreatic Neoplasms, Pancreatic Cancer
- Trial name
- NCT03152487
- Testing
- Celiac Plexus Neurolysis, Radiofrequency Ablation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- AdventHealth
Pancreatic Cyst
Safety and Efficacy of EUS-RFA in the Treatment of Pancreatic Lesions: A Prospective Registry
Purpose: The purpose of this registry is to track the clinical outcomes and progression of patients with pancreatic lesions receiving endoscopic ultrasound (EUS)-based radiofrequency ablation (RFA) therapy.
- Trial name
- NCT07136324
- Testing
- EUS-guided RFA treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pancreatic Cancer
Endoscopic Radiofrequency Ablation of Celiac Ganglion for Pain Management and Improvement of Quality of Life in Patients With Unresectable Pancreatic Cancer
This study aims to evaluate the EUS-RFA in terms of efficacy for pain management and improvement in quality-of-life parameters for patients with advanced inoperable pancreatic cancer.
- Trial name
- NCT05535894
- Testing
- Ablation of Celiac Ganglion
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- West Virginia University
Pancreatic Cancer, Pancreatic Neoplasms
Evaluation of Safety and Feasibility of EUS-guided RFA for Solid Pancreatic Neoplasms
This study aims to evaluate the safety and efficacy of new ablation catheter developed by MEDICAL TAEWOONG for the treatment of pancreatic neoplasm (pancreatic adenocarcinoma or neuroendocrine tumour).
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Pancreatic Adenocarcinoma, Pancreatic Neuroendocrine Tumor
- Trial name
- NCT03435770
- Testing
- EUSRA RFA needle
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Singapore General Hospital
Pancreatic Ductal Adenocarcinoma (PDAC)
EUS-RFA PANCARDINAL-1 Trial
The objectives of this study are to determine the feasibility, tolerability, and treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus standard-of-care neoadjuvant chemotherapy (NAC) in the treatment…
- Trial name
- NCT04990609
- Testing
- Endoscopic Ultrasound (EUS)-Guided Radiofrequency Ablation (RFA), Neoadjuvant Chemotherapy (NAC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pancreatic Ductal Adenocarcinoma
EUS-RFA for Unresectable Pancreatic Cancer
The clinical application of intraoperative or percutaneous radiofrequency ablation (RFA) for pancreatic ductal adenocarcinoma (PDAC) is limited due to higher mortality and incidence of adverse events.
- Trial name
- NCT04310111
- Testing
- EUS-RFA
- Where
- China
- Volunteers
- 8 people
- Sponsor
- First People's Hospital of Hangzhou
Pancreatic Cyst
A Phase II Multicentre Trial of Endoscopic Ultrasound Guided Radiofrequency Ablation of Cystic Tumours of the Pancreas
Up to 13.5% of patients that undergo a magnetic resonance imaging (MRI) scan of their abdomen without pancreatic symptoms are found to have an incidental pancreatic cyst, with the frequency increasing with age.
- Trial name
- RADIOCYST01 (NCT02343692)
- Testing
- EUS guided RFA of cystic tumours of the pancreas
- Where
- 13 sites in Australia, United Kingdom
- Volunteers
- 97 people
- Sponsor
- University College, London
Pancreatic Adenocarcinoma Non-resectable
EUS-RFA for Unresectable Pancreatic Ductal Adenocarcinoma
the study evaluate the efficacy and safety of EUS-RFA using Habib EUS-RFA catheter with a prospective randomised trial in patients with inoperable PDAC.
- Trial name
- NCT03772756
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, chemoradiotherapy
- Where
- 2 sites in China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Gastrointestinal Stromal Tumor (GIST)
Endoscopic Ultrasound Radiofrequency Ablation for GISTs
Nowadays, for the selection of the treatment for gastrointestinal stromal tumors (GISTs), tumor size, prognosis, resectability and stage should be considered.
- Trial name
- NCT05453292
- Testing
- Endoscopic ultrasound guided radiofrequency ablation
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Pancreatic Ductal Adenocarcinoma
A Clinical Study of EUS-RFA for Inoperable Pancreatic Ductal Adenocarcinoma
To assess if endoscopic ultrasound-guided radiofrequency ablation application in patients with inoperable pancreatic cancer confers survival benefit when compared to patients receiving standard medical care.
- Trial name
- EUS-RFA (NCT03444948)
- Testing
- EUS-RFA using Habib Tm as a probe, EUS
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)