Clinical trials: Endoscopic Submucosal Dissection
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)
This single-center, prospective, single-arm study will evaluate whether giving neoadjuvant chemoimmunotherapy can safely shrink esophageal cancer and allow organ-preserving endoscopic removal in selected patients.
- Trial name
- Endosurgery-02 (NCT07317609)
- Testing
- Tislelizumab, Carboplatin, Nab-paclitaxel
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Squamous Cell Neoplasm
RFA to Prevent Metachronous Squamous Neoplasia Recurrence After Complete Endoscopic Submucosal Dissection
Esophageal cancer is a highly lethal disease, and its incidence is still increasing in the world. Recent advances in image-enhanced techniques such as Lugol chromoendoscopy and narrow band imaging, the number of patients with…
- Trial name
- NCT03183115
- Testing
- Radiofrequency ablation, Endoscopy, Lugol's Solution (1.5%)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- E-DA Hospital
Colonic Polyps
Comparison Rectal Endoscopic Submucosal Dissection to Endoscopic Mucosal Resection
The investigators have recently become proficient in a new, and we believe more effective technique for polyp removal. Known as Endoscopic Submucosal Dissection (ESD). ESD involves removing the polyp in one piece.
- Trial name
- RESDEMR (NCT02198729)
- Testing
- Endoscopic Submucosal Dissection, Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Professor Michael Bourke
Rectal Cancer, Colo-rectal Cancer
Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resectional Surgery
When a patient is diagnosed with a rectal (bowel) polyp or cancer, radiology doctors read MRI scans to describe how deeply the cancer invades into the bowel wall (this is the 'stage' of the cancer).
- Trial name
- PRESERVE (NCT04103372)
- Testing
- MRI scan, Radiologist training
- Where
- 23 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Rectal Adenoma, Rectal Polyp
Transanal Resection of Rectal Lesions With the ColubrisMX ELS System
This study is a prospective, single-arm, multi-center, open-label, staged clinical study. Overall Objective: 1. To evaluate the safety and effectiveness of the ELS System in subjects undergoing transanal endoluminal procedures in…
- Conditions
- Rectal Adenoma, Rectal Polyp, Rectal Lesion
- Trial name
- NCT04651764
- Testing
- ColubrisMX Endoluminal Surgical (ELS) System
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- ColubrisMX
Gastrointestinal Neoplasms, Achalasia
ConMed Beamer Study
This is a prospective registry of all patients who endoscopic submucosal dissection (ESD), per-oral endoscopic myotomy (POEM) and gastric per-oral endoscopic myotomy (G-POEM) using ConMed Electrosurgical unit for submucosal…
- Conditions
- Gastrointestinal Neoplasms, Achalasia, Gastroparesis
- Trial name
- NCT04752670
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Early Cancer
Endoscopic Submucosal Dissection (ESD) and Endoscopic Mucosal Band Ligation (EMBL) for Early Cancer
To compare the treatment methods of endoscopic submucosal dissection (ESD) and endoscopic mucosal band ligation (EMBL) for early cancer.
- Trial name
- NCT02952794
- Testing
- endoscopic submucosal dissection (ESD) and endoscopic mucosal band ligation (EMBL) for early cancer
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Stomach Ulcer
Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?
Treatment strategy of post endoscopic submucosal dissection (ESD) ulcer is not yet conclusive. Rebamipide is a mucosal protective agent widely used in East Asia and has good effect on quality of ulcer healing (QOUH).
- Trial name
- NCT01167101
- Testing
- Rebamipide, pantoprazole
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Kangdong Sacred Heart Hospital
Esophageal Lesion, Barrett Esophagus
Endoscopic Submucosal Dissection (ESD)
This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic submucosal dissection. All patients will receive standard of medical care and no experimental interventions will be performed.
- Conditions
- Esophageal Lesion, Barrett Esophagus, Gastrointestinal Lesions
- Trial name
- ESD (NCT05468008)
- Testing
- Endoscopic Submucosal Dissection
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- AdventHealth
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Robot Surgery, Endoscopic Submucosal Dissection (ESD)
Efficacy and Safety of Robot-assisted Endoscopic Submucosal Dissection for Colorectal Neoplasm
The objective of this study is to investigate the role of the flexible auxiliary single-arm transluminal endoscopic robot (FASTER) system in colorectal endoscopic submucosal dissection (ESD) and to validate its superiority over…
- Conditions
- Robot Surgery, Endoscopic Submucosal Dissection (ESD), Colorectal Neoplasms
- Trial name
- NCT06973083
- Testing
- FASTER-assisted ESD, Conventional ESD
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Shandong University
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Early Gastric Cancer or Gastric Adenoma
Full-time RDI for ESD: Impact on Major Adverse Events and Procedure Time
Gastric cancer remains a major global health burden, ranking fifth in incidence worldwide and disproportionately affecting Asia, with China accounting for a significant share of cases and deaths.
- Trial name
- NCT07401303
- Testing
- ESD
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Gastric Submucosal Tumors, Endoscopic Full Thickness Resection (EFTR)
EDLS-clips in Endoscopic Full-thickness Resection
A retrospective analysis was conducted on patients who visited from March 2022 to May 2024 and underwent endoscopic full-thickness resection and double-layer suture with titanium clips under endoscopy.
- Trial name
- NCT07305038
- Testing
- endoscopic double-layer suturing method with metallic clips
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Hospital of China Medical University
Colon Polyp, Colon Neoplasia
Prospective Study of Using Novel Bipolar Scissors in Colorectal Endoscopic Submucosal Dissection
This study is an interventional, prospective, single-center study to evaluate the safety and effectiveness of a novel radiofrequency and microwave ablation flexible bipolar (SpydrBlade Flex, CREO Medical, UK) for colorectal ESD…
- Trial name
- NCT06715332
- Testing
- Colorectal ESD with SpydrBlade Flex
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Tracheal Intubation, Endoscopic Submucosal Dissection
Endoscopy-Assisted Tracheal Intubation Versus Conventional Tracheal Intubation for Endoscopic Submucosal Dissection (ESD)
This study plans to enroll 132 patients undergoing upper gastrointestinal endoscopic submucosal dissection (ESD). Patients will be randomly divided into a control group (conventional tracheal intubation) and an experimental group…
- Conditions
- Tracheal Intubation, Endoscopic Submucosal Dissection, Endoscopy-Assisted, Video Laryngoscope
- Trial name
- NCT06730984
- Testing
- Endoscopy-Assisted Tracheal Intubation, Traditional Tracheal Intubation
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Ningbo No. 1 Hospital
Anal Cancer
Early Rectal Cancer: Endoscopic Submucosal Dissection or Transanal Endoscopic Microsurgery?
Local excision for early rectal cancer has proven its feasibility and oncological safety. Indeed, lymph node invasion does not exceed 1% and 10% in pT1sm1 and pT1sm2 rectal carcinomas respectively.
- Trial name
- MUCEM (NCT02885142)
- Testing
- Local excision for early rectal cancer
- Where
- France
- Volunteers
- 368 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia
Comparison of the Sensitivity of pCLE and Pathological Biopsy Before ESD
Pathological biopsy before endoscopic submucosal dissection (ESD) the gastric lesion plays an important role in differentiating the pathological nature of the lesion and guiding treatment decisions.
- Conditions
- Gastric Cancer (Diagnosis), Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT07088744
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- 4 sites in China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer
Endoscopic Submucosal Dissection Combine With Laparoscopic Regional Lymph Node Dissection for Early Gastric Cancer
The purpose of this study is to determine whether Endoscopic Submucosal Dissection combine with Laparoscopic Regional Lymph node Dissection for early gastric cancer can improve Disease-free survival ？
- Trial name
- NCT02325999
- Testing
- ESD AND LRLD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Aspirin, Gastric Cancer
Aspirin Use for Gastric Cancer Prevention in the Early Gastric Cancer Patients
This study aimed to investigate the effect of low-dose (100 mg) asprin on the prevention of gastric cancer in the early gastric cancer patients with negative H. pylori status who underwent endoscopic submucosal dissection.
- Trial name
- EASTERN (NCT04214990)
- Testing
- Aspirin 100mg
- Where
- 10 sites in South Korea
- Volunteers
- 1,700 people
- Sponsor
- National Cancer Center, Korea