Clinical trials: Endometrium
Endometrium Cancer
Weight Management in Overweight Endometrial Cancer Patients Undergoing Fertility-sparing Treatment
In this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups.
- Trial name
- NCT06169449
- Testing
- Weight management--diet, Weight management--exercise, Weight management--accompany
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Infertility
Effects of Intrauterine Administration of Autologous PBMC Modulated With IFNt on Endometrial Cell Populations
The aim of this clinical trial is to investigate the change in endometrial composition during the window of implantation following intrauterine administration of PBMC immunomodulated with IFNt.
- Trial name
- NCT05775211
- Testing
- Intrauterine administration of PBMC immunomodulated with IFNt
- Where
- Bulgaria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nadezhda Women's Health Hospital
Cancer of the Endometrium
Comparing Robotics and Laparoscopy With Laparotomy/Open Surgery for Endometrial Cancer
The use of robotic surgery in the management of gynecologic cancers has increased exponentially in the United States since the implementation of technology in 2005.
- Trial name
- GOC2 (NCT01480999)
- Where
- 7 sites in Canada
- Volunteers
- 550 people
- Sponsor
- University Health Network, Toronto
Thin Endometrium, Female Infertility
Intrauterine G-CSF Infusion for Thin Endometrium
Thin endometrium is a condition in which the lining of the uterus is too thin during preparation for embryo transfer. This may reduce the chance of pregnancy and live birth in patients undergoing frozen-thawed embryo transfer.
- Trial name
- GIFT (NCT07692672)
- Testing
- Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline
- Volunteers
- 620 people
- Sponsor
- Nanjing University
Endometrium Cancer, Sentinel Lymph Node
Multimedia Aid Gynecologic Counseling and Consent
This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently.
- Conditions
- Endometrium Cancer, Sentinel Lymph Node, Perioperative/Postoperative Complications
- Trial name
- NCT03899441
- Testing
- Video
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Implantation Rate
Effect of Local Injury on Implantation
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
- Trial name
- NCT00846183
- Testing
- local injury
- Where
- Iran
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Metastatic Cancer, Endometrium Cancer
A Phase II Study of Futibatinib and Pembrolizumab in Metastatic Microsatellite Stable Endometrial Carcinoma
It's propose this pilot phase 2 study to explore the combination therapy of futibatinib with pembrolizumab in patients with metastatic microsatellite stable (MSS) endometrial carcinoma to provide a well-tolerated regimen for…
- Conditions
- Metastatic Cancer, Endometrium Cancer, Endometrial Carcinoma
- Trial name
- NCT05036681
- Testing
- Futibatinib, Pembrolizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Infertility, Infertility, Female
Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium
This study evaluate the percentage of women with thin endometrium who achieve an endometrial thickness equal to or greater than 7 mm after administration of PRGF (plasma rich in growth factors)
- Trial name
- APTE (NCT03387501)
- Testing
- Plasma rich in growth factors (PRGF-Endoret)
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Sara Rafael Fernandez
Endometrium Cancer
Relationship of Endometrial Cancer and Serum Soluble L1CAM Level
The aim of this study is to evaluate the effect of serum soluble L1CAM (sL1CAM) on the diagnosis and prognosis of endometrial cancer.
- Trial name
- NCT04603599
- Testing
- serum soluble L1CAM (sL1CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Kocaeli University
Contraception
Synthetic vs Natural Estrogen in Combined Oral Contraception
The main objective of the study is to compare the metabolic effects of natural estradiol and synthetic ethinylestradiol used in combined oral contraception in healthy women.
- Trial name
- SYLVI (NCT02352090)
- Testing
- Ethinyl estradiol / dienogest, Estradiol valerate / dienogest, Dienogest
- Where
- 2 sites in Finland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Infertility
The Effects of Two Endometrium Preparation Protocols in Frozen-thawed Embryo Transfer in Women With Irregular Cycles
There are two main cycle regimens used for endometrial preparation for frozen embryo transfer （FET) in women with irregular cycles: hormone replacement therapy cycles (HRT) in which the endometrium is artificially prepared by…
- Trial name
- NCT01780610
- Testing
- Letrozole and human chorionic gonadotrophin, estradiol and progesterone
- Where
- China
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
IVF, Endometrial Receptivity
Endometrial Effects of Sildenafil in Frozen-Thawed Cycles in Women With Thin Endometrium
Management of Thin endometrium in IVF is challenging. Thin endometrium is often defined as <7 mm or < 8 mm on the day of Human Gonadotropin administration(Bu and Sun, 2015; Wu et al., 2014).
- Trial name
- NCT04283435
- Testing
- Sildenafil Citrate, Estradiol Valerate
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Thin Endometrium, Intrauterine Adhesion
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
This is a non-blind self-control trial. We mainly compare the changes of endometrial thickness，changes in menstrual flow, and improvement in pregnancy before and after stem cell treatment in patients with thin endometrium.
- Trial name
- NCT03724617
- Testing
- umbilical cord mesenchymal stem cells combined with collagen scaffold
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Sir Run Run Shaw Hospital
Infertility
Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women
The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.
- Trial name
- NCT02219425
- Testing
- endometrial biopsy
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Endometriosis, Stem Cell Transplant
Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning
Background: Some transplant recipients have been found to have cells in their uterus that come from the donor. Researchers want to study uterine tissue from three different groups of women: (1) healthy volunteers, (2) people who…
- Conditions
- Endometriosis, Stem Cell Transplant, Healthy Volunteers
- Trial name
- NCT01468935
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Uterine Serous Carcinoma
A Study of Azenosertib (ZN-c3) in Women With Recurrent or Persistent Uterine Serous Carcinoma
This is a Phase 2 study to evaluate the clinical activity and safety of ZN-c3 (azenosertib) in adult women with recurrent or persistent uterine serous carcinoma (USC).
- Trial name
- NCT04814108
- Testing
- Azenosertib
- Where
- 56 sites in United States, Australia and 2 more
- Volunteers
- 92 people
- Sponsor
- K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Postmenopausal Women
Tibolone Endometrium Study (Study 32972)(P06470)
Tibolone has been registered for the treatment of climacteric symptoms and for the prevention of postmenopausal osteoporosis. This is a 2-year study to further confirm the endometrial safety of tibolone in comparison with CE/MPA.
- Trial name
- THEBES (NCT00745108)
- Testing
- tibolone, Tibolone 2.5 mg, CE/MPA
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Infertility, Female, Endometrium
The Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring
The purpose of the study is to evaluate the safety and effectiveness of the collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (UC-MSCs) in infetile women with thin endometrium or endometrial scarring.
- Trial name
- NCT03592849
- Testing
- UC-MSCs therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Fertility Disorders
Use of Gcsf in Patients With Recurrent Ivf/Icsi Failure
Evaluate the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of thin endometrium or in women with recurrent implantation failure in ICSI cycles
- Trial name
- NCT03023774
- Testing
- Neupogen
- Volunteers
- 20 people
- Sponsor
- Ain Shams Maternity Hospital
Postmenopausal Symptoms
A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women
The purpose of this study is to examine the effect of two different dose levels of estrogen or placebo in healthy postmenopausal women by measuring the changes in hormone levels and examining the changes in the uterine lining…
- Trial name
- NCT00820664
- Testing
- Comparator: Estrace 0.5 mg, Comparator: Estrace 2 mg
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC