Clinical trials: Endocarditis Infective
Infective Endocarditis, Endocarditis, Bacterial
Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment
Infective endocarditis (IE) is associated with high morbidity and mortality. Patients with IE are affected by a lengthy hospitalization, leading to physical deconditioning and a rapid decline in physical fitness, muscle mass and…
- Conditions
- Infective Endocarditis, Endocarditis, Bacterial, Infection; Heart, Bacteremia
- Trial name
- ENDOCARE (NCT06563609)
- Testing
- Intensive physical Therapy, Probiotic treatment, Individualised Nutritional Support
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Johannes Grand
Bacterial Endocarditis, Bacteremia
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus
The purpose of this study is to compare the safety and efficacy of daptomycin, an antibiotic, to standard therapy in subjects who have infective endocarditis or bacteremia due to Staphylococcus aureus (S. aureus).
- Trial name
- NCT00093067
- Testing
- daptomycin
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Infective Endocarditis
Clinical Metagenomics of Infective Endocarditis
Infective endocarditis (IE) is an infection of cardiac valves. IE mainly involves bacteria, more rarely fungi. IE is an uncommon diseases with an estimated incidence of 1-12 cases per 100,000 inhabitants per year.
- Trial name
- Meta-ENDO (NCT03199287)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Endocarditis Infective
The Role of Polymerase Chain Reaction in the Management of Patients With Infective Endocarditis
The aim of this study is to prospectively investigate the additional diagnostic value of broad range PCR targeting the 16 ribosomal DNA in diagnosis and management of patients with infective endocarditis who are candidate for…
- Trial name
- NCT05791357
- Testing
- PCR (Polymerase Chain Reaction) targeting the 16 ribosomal DNA
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Endocarditis, Bacterial
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis
Background: it is well known that most serious complications of infective endocarditis (IE) appear in the so-called "critical phase" of the disease, which are the first days after diagnosis.
- Trial name
- SATIE (NCT04222257)
- Testing
- Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Carmen Olmos Blanco
Endocarditis, Infective
Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.
Phase IV, open-label, randomized and multicenter clinical trial to prove that patients with Enterococcus faecalis infective endocarditis treated with an antibiotic treatment as a continuous infusion is non-inferior to the…
- Trial name
- DOBLEI (NCT06423898)
- Testing
- Ampicillin plus ceftriaxone in continuous infusion, Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed
- Where
- 18 sites in Spain
- Volunteers
- 284 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Endocarditis, Bacterial, Endocarditis
Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and/or History of Infective Endocarditis
Infective endocarditis (IE) continues to cause serious morbidity and mortality. To reduce its incidence, antibiotic prophylaxis has been recommended before invasive dental procedures in patients with at risk predispositions.
- Conditions
- Endocarditis, Bacterial, Endocarditis, Endocarditis Acute and Subacute
- Trial name
- PROPHETS (NCT05613933)
- Testing
- Improved practices
- Volunteers
- 250,000 people
- Sponsor
- University Hospital, Bordeaux
Endocarditis, Endocarditis;Chronic
64Cu-DOTATATE PET-CT-skanning and Infective Endocarditis.
The investigators hypothesize that the 64Cu-DOTATATE will show uptake in the infected vegetations on the prosthetic heart valves and increase the accuracy of the right diagnosis - thus increasing the sensitivity and specificity…
- Conditions
- Endocarditis, Endocarditis;Chronic, Endocarditis Acute
- Trial name
- NCT05432427
- Testing
- 64Cu-DOTATATE and 18F-FDG
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Emil Loldrup Fosbol
Infective Endocarditis, Cardiac Surgery
SURgical Registry of ENDocarditis EuRope
This is a prospective, multicentric, european registry of patients with infective endocarditis undergoing cardiac surgery. Patient demographics, clinical data and laboratory values will be collected, as well as treatment outcomes…
- Conditions
- Infective Endocarditis, Cardiac Surgery, Outcomes
- Trial name
- SURRENDER (NCT05563662)
- Testing
- Cardiac surgery
- Where
- 2 sites in Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Essen
Infective Endocarditis (IE), Severe Anemia
Anemia Therapy in Patients With Infective Endocarditis
Infective endocarditis (IE) is a bacterial infection of the heart valves, inserted material or surrounding struc-tures and is associated with a high morbidity and mortality.
- Trial name
- POET-IRON (NCT07523646)
- Testing
- Adjunctive anemia therapy
- Where
- Denmark
- Volunteers
- 74 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Endocarditis, Thrombosis
Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis
Intraluminal thrombi adherent to cardiac valves or atria share a common pathophysiology involving the aggregation of activated platelets with phosphatidylserine (PS) expression on the outer layer of the thrombus.
- Trial name
- AnnIE (NCT02459613)
- Testing
- 99mTc-Annexin V-128 SPECT
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Infective Endocarditis
Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR）
In this study, by establishing a clinical cohort of infective endocarditis, we observed the natural prognosis and influencing factors in the process of disease development and regression; we used multi-omics technology to…
- Trial name
- ENDEAVOR (NCT05965362)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Infective Endocarditis
Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis
Infective endocarditis (IE) is associated with high hospital mortality for various reasons; one of them is circulatory failure in patients who undergo cardiac surgery for IE.
- Trial name
- REMOVE (NCT03266302)
- Testing
- hemoadsorber for removal of cytokines
- Where
- 14 sites in Germany
- Volunteers
- 288 people
- Sponsor
- Jena University Hospital
Infective Endocarditis
The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan
Infective endocarditis has long been one of the significant diseases causing death and disability worldwide. Its incidence has shown an increasing trend over the past few decades.
- Trial name
- NCT07156292
- Testing
- Observational study, not interventional
- Where
- Taiwan
- Volunteers
- 2,247 people
- Sponsor
- National Taiwan University Hospital
Infective Endocarditis (IE)
Outcomes of Surgical Treatment in Patients With Infective Endocarditis
Infective endocarditis (IE) is a severe disease associated with significant morbidity and mortality despite advances in antimicrobial therapy and cardiac surgery.
- Trial name
- ETCEI (NCT07529730)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Staphylococcus Aureus Bacteremia
Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia
The purpose of this study was to compare the efficacy and safety of ceftobiprole medocaril versus a comparator in the treatment of patients with complicated Staphylococcus aureus bacteremia (SAB).
- Trial name
- NCT03138733
- Testing
- Ceftobiprole medocaril, Daptomycin
- Where
- 60 sites in United States, Argentina and 15 more
- Volunteers
- 390 people
- Sponsor
- Basilea Pharmaceutica
Infective Endocarditis (IE)
Inflammation and Infective Endocarditis
Infective endocarditis (IE) is caused by bloodstream bacteria becoming adherent to, and eventually destroying, heart valve tissue.
- Trial name
- NCT06871215
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Endocarditis, Bacterial
Bacteriophages in Addition to Antibiotics for the Treatment of Patients With Infective Endocarditis
Infective endocarditis (IE) is an endocardial lesion caused by bacterial and/or fungal infection that most commonly affects the heart valves and/or the endocardium around implanted intracardiac devices.
- Trial name
- PHARAOH (NCT06870409)
- Testing
- Bacteriophage
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- University Clinical Hospital na V.V.Vinogradov (branch of RUDN university na Patrice Lumumba)
Prosthetic Valve Endocarditis
Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis
In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify…
- Trial name
- EndEOTEP (NCT05989152)
- Testing
- FDG-PET at the end of treatment for IE
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Background Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right ventricular outflow tract dysfunction in patients with congenital heart diseases.
- Conditions
- Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation, Infective Endocarditis, Congenital Heart Disease
- Trial name
- EUROPULMS3 (NCT05264181)
- Testing
- Percutaneous pulmonary valve implantation
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Chirurgical Marie Lannelongue