Clinical trials: End of Life Care
Any Disease Causing Death in the ICU or Within 24 Hours of Discharge From the ICU
Integrating Palliative and Critical Care (IPACC) Study
The purpose of this research study is to evaluate an intervention to improve the care given to patients who are dying in the intensive care unit (ICU) and their families.
- Trial name
- IPACC (NCT00685893)
- Testing
- Education, Local Champions, Institution Feedback
- Where
- 15 sites in United States
- Volunteers
- 3,498 people
- Sponsor
- University of Washington
End-of-life, Depression, Anxiety
Improve Mental Health and Emotional Labor Among Nurses Who Care the End-of-life Patients
CBT: cognitive behavioural therapy MBT: mindfulness-based therapy
- Trial name
- NCT05541523
- Testing
- cognitive behavioural therapy, mindfulness-based therapy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Huichao Zhang
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
Urothelial Cancer
A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic…
- Trial name
- NCT02603432
- Testing
- Avelumab, Best Supportive Care, Following the planned interim analysis for this study: Avelumab
- Where
- 382 sites in United States, Argentina and 27 more
- Volunteers
- 700 people
- Sponsor
- Pfizer
Prenatal Care
Prenatal Care Program in Dingyuan County
The general objective of this study is to evaluate prenatal care in the specific context of rural China. It also aims to define the optimal content of prenatal care for the context of rural China, to evaluate the effect of such…
- Trial name
- EPCP (NCT01054235)
- Testing
- training
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Finnish Institute for Health and Welfare
Palliative Care, Intensive Care Unit
Critical Care and Palliative Care Medicine Together in the ICU
Will earlier palliative care medicine consultation in the ICU result in decreased length of stay in the ICU and hospital, as well as, increased patient and family satisfaction.
- Conditions
- Palliative Care, Intensive Care Unit, Hospice
- Trial name
- NCT03520023
- Testing
- Palliative Care Consult
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Mayo Clinic
Terminal Illness, End of Life
Elaboration of a Multi-dimensional Indicator of Quality in Palliative Care
The purpose of this study is to elaborate a multi-dimensional indicator of the quality in palliative care for patients of end-of-life.
- Trial name
- QUALI-PALLI (NCT02814682)
- Where
- France
- Volunteers
- 560 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain
Aromatherapy Protocol for Pain Reduction in Hospice Patients
The purpose of this study is to introduce aromatherapy with current pain medication protocols to see if it improves patient satisfaction and reduces pain in hospice care patients.
- Trial name
- NCT05617144
- Testing
- Aromatherapy treatment
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
The Effective Factors on the Grief Reactions to the Death Information
Breaking the Bad News to the Bereaved Family and Their Reactions
The demographic characteristics, satisfaction survey evaluations and emotional reactions of the relatives of the patients who are admitted to the intensive care unit and who have an expected mortality rate higher than 50%…
- Trial name
- NCT04385628
- Testing
- the patient' relatives satisfaction questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Squamous Cell Carcinoma of Head and Neck
Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)
Researchers are looking for new ways to treat people with head and neck cancer whose cancer has come back after treatment (recurrent) or whose cancer has spread to other parts of the body (metastatic).
- Trial name
- NCT04428151
- Testing
- Lenvatinib, Pembrolizumab, Docetaxel
- Where
- 120 sites in United States, Australia and 13 more
- Volunteers
- 408 people
- Sponsor
- Merck Sharp & Dohme LLC
Palliative Care, Terminal Care
Appropriate Medication Use in Dutch Terminal Care
The AMUSE trial is a multicentre stepped-wedge cluster randomized controlled trial where medication optimization of patients with a life expectancy of less than three months is investigated by using CDSS-OPTIMED (a personalized…
- Conditions
- Palliative Care, Terminal Care, Medication Therapy Management, Clinical Decision Support System (CDSS)
- Trial name
- AMUSE (NCT05351281)
- Testing
- CDSS-OPTIMED
- Where
- 7 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Prof.dr Carin (C.C.D.) van der Rijt
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
SARS CoV 2 Infection, RSV Infections
Expression of Inflammatory Markers in the Course of Acute Respiratory Viral Infections
Respiratory viral infections caused by influenza, respiratory syncytial virus (RSV), and SARS-CoV-2 remain major causes of morbidity, hospitalization, and mortality among older adults worldwide.
- Conditions
- SARS CoV 2 Infection, RSV Infections, Influenza Infection
- Trial name
- AIRE-INT (NCT07643688)
- Volunteers
- 150 people
- Sponsor
- Fabiana Sherine Ganem dos Santos
Critical Illness
Decision Support Among Surrogate Decision Makers of the Chronically Critically Ill (INVOLVE)
Each year, millions of Americans are admitted to an intensive care unit (ICU). For more than half of them, ICU admission initiates a cascade of decisions about treatment and end-of-life care.This is particularly the case for…
- Trial name
- INVOLVE (NCT03099746)
- Testing
- INVOLVE, Informational Support, Usual Care
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Terminal Illness
iLIVE Volunteer Study
The aim of this study is to develop and evaluate the implementation of an international volunteer training programme to support patients dying in the hospital setting and their families. It has the following objectives: 1.
- Trial name
- NCT04678310
- Testing
- Support from the hospital palliative and end of life care volunteer service (developed for this study).
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Liverpool
Patient Engagement, End of Life
Advance Care Planning for Older Latinos With Chronic Illness
The goal of this study is to test the feasibility of a randomized controlled trial to learn about implementation of an intervention model, Advance Care Planning I Plan (ACP-I Plan), among older Latinos with chronic illnesses in…
- Conditions
- Patient Engagement, End of Life, Chronic Disease, Communication
- Trial name
- NCT06081660
- Testing
- ACP-I Plan
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Chronic Kidney Diseases
A Pilot Study of The CKM JumpStart Tool
This is a randomized pilot study to test the feasibility and acceptability of a tool to promote discussion about conservative kidney management (CKM) among older patients with advanced CKD and their providers.
- Trial name
- NCT05753020
- Testing
- CKM Jumpstart Tool
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Washington
Still Births, Bereavement
Perinatal Bereavement Counseling Training for Midwives
Perinatal bereavement is a condition that can lead to serious psychological problems for parents and their families. Bereaved women are at high risk of mental health problems (e.g.
- Conditions
- Still Births, Bereavement, Perinatal Care, Perinatal Mental Health
- Trial name
- NCT06652373
- Testing
- Behavioural change through education
- Volunteers
- 126 people
- Sponsor
- Istanbul University - Cerrahpasa
Dementia
Animal-Assisted Therapy for People With Dementia
This study is a qualitative anthropological research that explores the effects of Animal-Assisted Therapy (AAT) for people with moderate and severe dementia living in a care facility.
- Trial name
- AATPD (NCT03946696)
- Testing
- Interactions with therapy-animals
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Family Caregiving for a Palliative Patient
Supporting Family Caregivers of Palliative Patients at Home: the Carer Support Needs Assessment Intervention
In this project the investigators will train home care nurses to use the Carer Support Needs Assessment Tool (CSNAT) with a group of family caregivers (intervention group) and then compare the family caregivers' quality of life…
- Trial name
- CSNAT (NCT02261935)
- Testing
- Existing home care nursing practice, Practice support tool intervention
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Kelli Stajduhar