Clinical trials: Enamel Demineralization, active
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
White Spot Lesion of Tooth, Orthodontic Treatment
S-PRG Filler for Preventing White Spot Lesions During Orthodontic Treatment
White spot lesions are early areas of enamel demineralization that may develop during orthodontic treatment with fixed braces. This study aims to evaluate the effectiveness of S-PRG Barrier Coat in preventing white spot lesions…
- Conditions
- White Spot Lesion of Tooth, Orthodontic Treatment, Enamel Demineralization, Fluoride Varnishes
- Trial name
- SPRG-WSL (NCT07839780)
- Testing
- S-PRG Barrier Coat, S-PRG Barrier Coat + 5% Sodium Fluoride Varnish, 5% sodium fluoride varnish
- Where
- Malaysia
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Demineralization, Tooth, White Spot Lesion of Tooth
Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries
Fixed orthodontic patients are at risk of developing dental caries. Topical application of fluoride varnish (FV) around the orthodontic brackets and using fluoridated mouth rinses have been suggested to prevent the formation of…
- Conditions
- Demineralization, Tooth, White Spot Lesion of Tooth, Fixed Appliances, Early Caries Lesions
- Trial name
- NCT06797882
- Testing
- Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline
- Where
- Malaysia
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Molar-Incisor Hypomineralization (MIH)
Total Pulpotomy With Two Repair Cements in Hypomineralized Teeth
BRIEF SUMMARY The goal of this clinical trial is to learn whether two materials used during pulpotomy treatment can reduce pain after treatment in children with molar-incisor hypomineralization (MIH), deep tooth decay, and…
- Trial name
- DOR-PULP (NCT07774806)
- Testing
- MTA group, CIMMO DTA® group
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Meire Coelho Ferreira
White Spot Lesions, Enamel Demineralization
A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding
This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding.
- Trial name
- NCT07291830
- Testing
- Remineralizing self-etch primer (M-SEP, SEP 1), Standard self-etch primer (P-SEP, SEP 2)
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
White Spot Lesions
"Clinical Evaluation of Self-Assembling Peptides Versus Tri-Calcium Phosphate Based Varnish in Treatment of White Spot Lesions; Split-Mouth Randomized Clinical Trial"
Brief Summary: This randomized controlled clinical trial will evaluate the effectiveness of two remineralizing agents in the treatment of white spot lesions (WSLs) in young adults.
- Trial name
- SAP VS TCP (NCT07289932)
- Testing
- Curodont Repair (SAP P11-4), Clinpro White Varnish (Tri-Calcium Phosphate, TCP)
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Cervical Caries
Clinical Evaluation of Self-Adhesive Flowable Giomer With and Without Selective Enamel Etching
This randomized clinical trial is to evaluate the clinical performance of the self-adhesive flowable Giomer with and without selective enamel etching compared to flowable Giomer using standard bonding protocol in class V cavity…
- Trial name
- NCT07575646
- Testing
- Beautifil Flow Plus F00, FIT SA after selective enamel etching, FIT SA
- Volunteers
- 75 people
- Sponsor
- Cairo University
Esophagogastric Cancer
A Study of Tooth Erosion in People With Esophagogastric Cancer
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer…
- Trial name
- NCT05612048
- Testing
- Survey, Intra-oral camera, Optional Salvia sample
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
White Spot Lesions
The Effect of Nano Chitosan Surface Coating on White Spot Lesions Development in Clear Aligner Therapy Patients
In this study, it was intended to investigate the effect of nano Chitosan (antimicrobial agent) coating on clear aligner orthodontic appliance if it reduces the incidence of white spot lesions (demineralization) of enamel…
- Trial name
- NCT07715552
- Testing
- chitosan nanoparticles, No Treatment Added
- Where
- Jordan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Molar Incisor Hypomineralisation, Dental Caries
Selective Versus Non-selective Caries Excavation in MIH Affected Teeth.
The aim of this study is to compare the clinical and radiographic outcomes of selective versus nonselective caries removal in MIH affected teeth with deep carious lesions using enhanced clinical protocols.
- Trial name
- NCT07142629
- Testing
- Selective caries removal, Non-Selective caries removal
- Where
- Jordan
- Volunteers
- 60 people
- Sponsor
- King Abdullah University Hospital
Dental Caries, Tooth Hypomineralization
Zirconia and Bioflx Crowns for Primary Anterior Teeth
This parallel-group randomized controlled trial will compare the clinical performance of prefabricated zirconia and Bioflx crowns for restoring primary maxillary anterior teeth in children aged 3 to 5 years.
- Trial name
- NCT07691905
- Testing
- Zirconia Crown, Bioflx Crown
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- Hue University of Medicine and Pharmacy
Molar Incisor Hypomineralization, Dental Caries
Prevalence of MIH in Young Adults At Cairo University Dental Hospital and Its Link to Dental Cavities: a Cross-Sectional Study
We are conducting a study to understand how often MIH (Molar Incisor Hypomineralization) occurs and whether it is linked to a higher chance of dental cavities (caries).
- Trial name
- NCT06701552
- Where
- Egypt
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthodontic Aligner Material, Enamel Demineralization
Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties
Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization.
- Conditions
- Orthodontic Aligner Material, Enamel Demineralization, Dental Biofilm Formation, Clear Aligner Material Properties
- Trial name
- 3D-BIOALIGN (NCT07603427)
- Testing
- Modified 3D-Printed Orthodontic Aligner Resin
- Where
- Iraq
- Volunteers
- 400 people
- Sponsor
- University of Baghdad
Tooth Demineralization, Tooth Sensitivity
Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study
This study evaluates the clinical performance, marginal integrity, surface wear, color stability, and postoperative sensitivity of graphene-reinforced CAD/CAM indirect restorations (inlays, onlays, overlays) in molars affected by…
- Conditions
- Tooth Demineralization, Tooth Sensitivity, Enamel Mineralization Disorders, Tooth Sensitivity After Composite Restorations
- Trial name
- NCT07329244
- Testing
- Graphene-reinforced CAD/CAM polymer (G-CAM®)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universitat Internacional de Catalunya
Tooth Demineralization, White Spot Lesion
Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets
White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances.
- Conditions
- Tooth Demineralization, White Spot Lesion, Demineralization, Orthodontic Appliance Complication
- Trial name
- ORTHOCOLLAGE (NCT07355322)
- Testing
- Transbond™ XT bonding procedure, GC Ortho Connect™ bonding procedure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Celiac Disease, Dentin Hypersensitivity
Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients
This single-center, randomized controlled clinical trial aims to evaluate the effectiveness of a home-based treatment using hydroxyapatite-based oral care products in adult patients with celiac disease who exhibit enamel…
- Conditions
- Celiac Disease, Dentin Hypersensitivity, Tooth Demineralization
- Trial name
- CELIADENT (NCT07069127)
- Testing
- Biorepair Toothpaste and Mousse, Biorepair® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth.
- Trial name
- NCT07146464
- Testing
- Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University