Clinical trials: Emergency Surgery
Emergency Abdominal Surgery, Opioid Sparing Anaesthesia
Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency Laparotomy
Opioids are widely used during anesthesia for pain control, but they cause many side effects-such as nausea, constipation, respiratory depression, dependence, and delayed recovery.
- Trial name
- NCT07262242
- Testing
- Lidocaine (drug), Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Emergency General Surgery
STRATA: Surgical Treatment Using Robotic Approach in The Acute Abdomen
Robotic surgery in the UK is now widely used in elective procedures based on evidence that it can improve outcomes, with improved vision and precision for the surgeon resulting in better results and greater rates of minimally…
- Trial name
- STRATA (NCT07850401)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Open Abdomen, Incisional Hernia
Synthetic Mesh for Prevention of HernIa After opEn Abdomen cLosure stuDy
The aim of this clinical trial is to evaluate whether placement of a synthetic prophylactic onlay mesh during definitive fascial closure can reduce the incidence of incisional hernia in adult patients managed with an open abdomen…
- Conditions
- Open Abdomen, Incisional Hernia, Definitive Fascial Closure, Emergency Abdominal Surgery
- Trial name
- SHIELD (NCT07835334)
- Testing
- Definitive Fascial Closure Without Prophylactic Mesh, Prophylactic Onlay Mesh Placement
- Volunteers
- 30 people
- Sponsor
- Hospital San Juan de Dios Tenerife
Emergency General Surgery Laparotomy
Surgical Apgar Score for Identifying Patients Who May Need Intensive Care After Emergency Abdominal Surgery
This prospective observational study will evaluate whether the Surgical Apgar Score can help identify patients who require direct admission to the intensive care unit after emergency abdominal surgery.
- Trial name
- SAS-ICU (NCT07814131)
- Where
- Pakistan
- Volunteers
- 77 people
- Sponsor
- King Edward Medical University
Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)
The PREEMPT trial is a multicenter randomized controlled trial comparing prophylactic onlay biosynthetic mesh reinforcement with primary suture closure in adult patients undergoing emergency midline laparotomy.
- Trial name
- PREEMPT (NCT07753551)
- Testing
- Prophylactic Biosynthetic Mesh Placement, Direct suture
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- University of Rome Tor Vergata
Hypotension on Induction, Emergency Surgery
5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment.
- Conditions
- Hypotension on Induction, Emergency Surgery, Norepinephrine
- Trial name
- NCT07719075
- Testing
- Norepinephrine 10 mcg, Norepinephrine 5 mcg
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Cairo University
COVID-19, Emergency Surgery
Treatment and Outcomes in Patients With COVID-19 and Competing Acute Surgical Diseases in Moscow
The COVID-19 pandemic has posed a significant challenge to surgical practice. This study aims to investigate the structure of hospitalizations, treatment outcomes, and surgical tactics in patients with COVID-19 and competing…
- Conditions
- COVID-19, Emergency Surgery, Abdominal Surgery, Real-World Data
- Trial name
- SurgCOVID-Mos (NCT07719166)
- Testing
- Surgical and Interventional Management of Acute Surgical Conditions
- Where
- Russia
- Volunteers
- 58,000 people
- Sponsor
- Pirogov Russian National Research Medical University
Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment
China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）
Background: Although emergency surgery may reduce mortality in patients with severe spontaneous intracerebral hemorrhage (SSICH), the effectiveness and safety of surgical treatment among SSICH patients receiving long-term oral…
- Conditions
- Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications
- Trial name
- NCT05975398
- Testing
- Emergency neurosurgery, Conservative treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Risk Factors, Complication of Surgical Procedure
ACUTE-Acute Surgical Care- Risk Factors and Outcomes for Patients in Need of Acute Surgical Care
Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.
- Conditions
- Risk Factors, Complication of Surgical Procedure, Complication of Treatment, Complication of Anesthesia
- Trial name
- ACUTE (NCT05195697)
- Testing
- Observational study of different treatments and time to treatment
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Region Skane
Emergency Laparotomy, Intestinal Obstruction
Enhanced Recovery Versus Standard Care After Emergency Abdominal Surgery in Patients Requiring Emergency Laparotomy
This study aims to compare an Enhanced Recovery After Surgery (ERAS) protocol with conventional postoperative care in adults undergoing emergency laparotomy for intestinal obstruction or intestinal perforation.
- Conditions
- Emergency Laparotomy, Intestinal Obstruction, Intestinal Perforation, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT07650461
- Testing
- Enhanced Recovery After Surgery, Conventional Postoperative Care
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
Emergency Surgery, Mortality
Surgical Emergencies Gradation and Postoperative Outcome
Reducing surgical waiting time has been shown to be associated with a reduction in postoperative morbidity and mortality in this type of surgery.
- Trial name
- BUGRADA (NCT05888948)
- Where
- France
- Volunteers
- 756 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pulmonary Aspiration of Gastric Contents, Emergency Surgery
Gastric Ultrasound for Airway Management in Emergency Patients
This prospective observational cohort study evaluates the association between gastric residual content and volume, assessed by point-of-care gastric ultrasound (PoCUS), and the choice of airway management technique (Rapid…
- Conditions
- Pulmonary Aspiration of Gastric Contents, Emergency Surgery, Gastric Residual Volume, Airway Management
- Trial name
- NCT07640165
- Testing
- Preoperative Gastric Point-of-Care Ultrasound (PoCUS)
- Where
- Indonesia
- Volunteers
- 43 people
- Sponsor
- Universitas Indonesia
Hernia, Emergencies
Management of Acutely Symptomatic Hernia
Acutely symptomatic abdominal wall hernia can cause many symptoms and complications. They can be associated with levels of morbidity beyond that seen in emergency laparotomy. There is limited data to guide practice in this field.
- Conditions
- Hernia, Emergencies, Surgery--Complications
- Trial name
- MASH (NCT04197271)
- Testing
- Emergency Hernia Repair, Conservative management
- Where
- United Kingdom
- Volunteers
- 280 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Laparoscopic Surgery, Colorectal Cancer
Laparoscopic Approach for Emergency Colon Resection
This is a randomized, controlled, parallel, multicenter trial to compare post-operative complications and long-term results between open and laparoscopic technique in emergency colorectal surgery.
- Conditions
- Laparoscopic Surgery, Colorectal Cancer, Colorectal Disorders, Emergencies
- Trial name
- NCT05005117
- Testing
- Laparoscopic operation, Open operation
- Where
- Finland
- Volunteers
- 192 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Emergency Abdominal Surgery, Mechanical Ventilation
Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery
The aim of this study is to compare the effects of a strategy aimed at increasing alveolar recruitment (high PEEP levels adjusted according to driving pressure and recruitment maneuvers) with that of a strategy aimed at…
- Conditions
- Emergency Abdominal Surgery, Mechanical Ventilation, General Anesthesia, Postoperative Morbidity
- Trial name
- IMPROVE-2 (NCT03987789)
- Testing
- Driving-pressure-guided group, Low PEEP
- Where
- 28 sites in France
- Volunteers
- 707 people
- Sponsor
- University Hospital, Clermont-Ferrand
Emergency Abdominal Surgery
Physiotherapy After Emergency Laparotomy in the Elderly
Emergency laparotomy is associated with high postoperative morbidity and mortality. This risk is particularly high among elderly patients, who often present with reduced physiological reserve, frailty, and multimorbidity.
- Trial name
- NCT07504185
- Testing
- Experimental (Structured postoperative physiotherapy), Standard postoperative care
- Where
- Cyprus
- Volunteers
- 250 people
- Sponsor
- University of Cyprus
Emergency General Surgery
Anticoagulation in Emergency General Surgery
While DOACs are increasing in use in the EGS patient population, the risk of bleeding and the reversal of these agents to reduce hemorrhage is still evolving.
- Trial name
- NCT04216394
- Testing
- Emergency general surgery
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Methodist Health System
Paracetamol, Hypotension Drug-Induced
Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy
Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging.
- Conditions
- Paracetamol, Hypotension Drug-Induced, Emergency Surgery
- Trial name
- NCT07466108
- Testing
- Paracetamol (acetaminophen)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Emergency Surgery, Acute Kidney Injury
Preoperative Hemoglobin and Acute Kidney Injury in Emergency Surgery
Optimization of hemoglobin levels for organ perfusion is essential, especially in critically ill patients. Although anemia is associated with severe organ failure, especially in coronary artery disease, the effects of blood…
- Conditions
- Emergency Surgery, Acute Kidney Injury, Hemoglobin
- Trial name
- NCT06857630
- Testing
- Observational
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Samsun University
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center