Clinical trials: Emergencies
Rhabdomyolysis, Death
The Rhabdomyolysis Evaluation in the Emergency Department (REED) Score
One in three adults over 65 fall annually, with one in five remaining on the floor for greater than one hour, which is referred to as a long lie.
- Conditions
- Rhabdomyolysis, Death, Kidney Replacement Therapy, Fall Patients
- Trial name
- The REED Score (NCT07158554)
- Where
- United Kingdom
- Volunteers
- 1,161 people
- Sponsor
- University of Salford
Acute Heart Failure (AHF), Implementation Research
Implementation of Acute Heart Failure Checklist
Patients with acute heart failure (AHF) commonly present to the emergency department (ED) with difficulty breathing and often have poor outcomes or death.
- Trial name
- NCT07727304
- Testing
- CAEP Acute Heart Failure (AHF) Best Practices Checklist Implementation, Usual care
- Where
- Canada
- Volunteers
- 5,040 people
- Sponsor
- Ottawa Hospital Research Institute
Emergency Care
Descriptions and Practices of Family Engagement in Emergency Care Setting
The purpose of this study is to explore and describe nurses' perceptions of their levels and practices of family engagement in Emergency Departments and the experiences of family members in delivery of Emergency Department care.
- Trial name
- NCT07739576
- Testing
- Nurse Interview, Family Interview
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Acute Respiratory Failure (ARF)
Work of Breathing Predicts Noninvasive Ventilation Failure
Acute respiratory failure is a condition in which the lungs cannot provide enough oxygen or remove enough carbon dioxide from the blood. Noninvasive ventilation supports breathing through a mask.
- Trial name
- NCT07870174
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Izmir Katip Celebi University
Difficult Intravenous Access, Midline Catheter
Single Lumen Midline Catheter vs Long Peripheral Intravenous Cather for Difficult Intravenous Access in the ED
Many patients in the emergency department have veins that are difficult to get an intrevenous (IV) catheter into (called "difficult IV access").
- Conditions
- Difficult Intravenous Access, Midline Catheter, Peripheral Intravenous Catheter, Emergency Department Patient
- Trial name
- NCT06668766
- Testing
- 10-cm Single Lumen Mildine, 4.78 cm Long Peripheral Intravenous Catheter
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Albany Medical College
Hypertension, Acute Severe Hypertension
Study of Efficacy and Safety of Tonlamarsen in Participants With a Recent Hospitalization and a Concurrent Episode of Acute Severe Hypertension
The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who were recently hospitalized and concurrently experienced an episode of acute severe hypertension.
- Conditions
- Hypertension, Acute Severe Hypertension, Hypertensive Emergency, Hypertensive Urgency
- Trial name
- KARDINAL-ASH (NCT07511361)
- Testing
- Tonlamarsen
- Where
- 13 sites in United States
- Volunteers
- 140 people
- Sponsor
- Kardigan, Inc.
Alcohol Misuse
Advancing Scalable Alcohol Brief Interventions in the ED: A Trial of Conversational AI With Digital Reinforcements
The goal of this clinical trial is to learn if a novel digital strategy combining a generative AI counseling agent (MICA) and weekly SMS boosters works to reduce risky drinking among Emergency Department patients.
- Trial name
- MICA-ED (NCT07661563)
- Testing
- MICA, TRAC
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Stanford University
Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Embolism Registry From Short-Term Emergency to Long-Term Follow-Up and Surveillance
PERSEUS is an academic, investigator-initiated, multicenter observational registry of adults with acute pulmonary embolism (PE), promoted by Azienda Ospedaliero-Universitaria Careggi (Florence, Italy).
- Conditions
- Venous Thromboembolism (VTE), Chronic Thromboembolic Pulmonary Hypertension, Right Ventricular Dysfunction, Pulmonary Embolism (PE)
- Trial name
- PERSEUS (NCT07855679)
- Testing
- Routine clinical care (no study intervention)
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Suicidal Ideation
Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency Department
Participants are asked to take part in this research study after coming to the Emergency Department with thoughts or behaviors of seriously hurting themselves.
- Trial name
- ASPIRED (NCT07868913)
- Testing
- Ketamine Injectable Solution, Crisis Response Plan, Safety Planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Procedural Sedation
Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.
This randomized controlled trial will compare two medication combinations, ketamine-dexmedetomidine (Ketadex) and ketamine-propofol (Ketofol), for procedural sedation in adults undergoing painful procedures in the emergency…
- Trial name
- NCT07874919
- Testing
- Ketamine (1 mg/kg), propofol, Dexmedetomidine
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Sultan Qaboos University
Suicide
CAMS Relational Agent System (CAMS-RAS) for Suicide Prevention
This Phase II study is a continuation of the Phase I feasibility study where the investigators fully met and exceeded project aims to design, build, and test the usability and acceptability of an avatar-based system, Jaspr Health…
- Trial name
- V-CAMS (NCT03584386)
- Testing
- Jaspr, Jaspr-at-Home (JAH)
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Evidence-Based Practice Institute, Seattle, WA
Pain Management
Hypnosis Antalgia Emergency Stitching
Pain is one of the most common reasons patients seek care in emergency departments. Managing pain effectively is an important part of emergency care because it can improve patients' comfort and overall experience.
- Trial name
- HYPNAUS (NCT07872891)
- Testing
- hypnotic guidance
- Volunteers
- 134 people
- Sponsor
- University Hospital, Angers
Emergencies
Remote Oximeter Monitoring Post-discharge to Reduce Emergency Room Visits and Rehospitalization
This randomized clinical trial will determine the efficacy of remote patient monitoring using an Owlet OSS 3.0 pulse oximeter for the reduction of emergency room visits and high-acuity rehospitalizations among high-risk infants…
- Trial name
- ROMPER (NCT06565390)
- Testing
- Babies in the Owlet monitor group
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Alabama at Birmingham
Community Acquired Pneumonia (CAP)
Chest Radiography Versus Ultra-Low-Dose Chest Computed Tomography in Adults in the Emergency Department
Objective: To quantify and compare total staff person-time per imaging episode betweenconventional chest radiography (CXR) and ULDCT in adult emergency department patients in whom CAP is a differential diagnosis.
- Trial name
- TIME-CAP (NCT07870525)
- Testing
- ULDCT
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- University of Southern Denmark
Emergency Nursing Education, Cardiopulmonary Resuscitation Training
Development and Evaluation of an Emergency Nursing Care Training Program Focusing on CPR and Triage for the Lao People's Democratic Republic
In low- and middle-income countries, particularly the Lao People's Democratic Republic, limited infrastructure and constrained educational access create competency gaps and limited training opportunities for emergency nurses.
- Conditions
- Emergency Nursing Education, Cardiopulmonary Resuscitation Training, Triage Training
- Trial name
- NCT07871474
- Testing
- Emergency Nursing Training Program
- Where
- Laos
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Inje University
Emergency Medicine
Propensity to Hospitalize Patients From the ED in European Centers.
The peer-to-peer comparison means center-to-center comparison, which requires adjusting for possible differences among centers to be fair and convincing.
- Trial name
- eCREAM-UC1 (NCT06354764)
- Testing
- no intervention
- Where
- 2 sites in Italy
- Volunteers
- 162,000 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Emergency Medicine
Development of a Multipurpose Dashboard to Monitor the Situation of Emergency Departments
An emergency department (ED) is a healthcare service that provides the first clinical assessment and treatment to patients with various acute conditions.
- Trial name
- eCREAM-UC2 (NCT06372379)
- Testing
- no intervention
- Where
- 2 sites in Italy
- Volunteers
- 162,000 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Emergency Departments
Emergency and Urgent Care Indicators in Piedmont
The Emergency Department represents the main entry point to the hospital and a key setting for the management of urgent healthcare needs in the population.
- Trial name
- PRIME (NCT07606209)
- Where
- Italy
- Volunteers
- 650,000 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Hypotension and Shock, Wounds and Injuries
Prehospital Management of Hypotensive Trauma in HEMS
Up to today, inadequate evidences and knowledge exist about the best prehospital management of hypotensive trauma patients and its clinical consequence on the in-hospital recovery and mortality.
- Conditions
- Hypotension and Shock, Wounds and Injuries, Emergencies, Critical Care
- Trial name
- SPITFIRE (NCT04760977)
- Where
- 16 sites in Italy
- Volunteers
- 1,268 people
- Sponsor
- Azienda Usl di Bologna
Acute Respiratory Failure
A Check-list Including Lung Ultrasound for ED Patients With ARF
The aim of the study is to evaluate if a check-list including lung ultrasonography can help to identify the etiology of the acute respiratory failure of patients managed at the emergency room.
- Trial name
- CHECKIRA-COVID (NCT04791241)
- Testing
- check-list including lung ultrasound
- Where
- 3 sites in France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Metropole Savoie