Clinical trials: Embryo Culture Media
Infertility
Hyaluronan in Embryo Transfer Media
Prospective randomized double blind comparison of hyaluronan enriched embryotransfer media and conventional embryotransfer media in human IVF treatments.
- Trial name
- NCT02077608
- Where
- Hungary
- Volunteers
- 580 people
- Sponsor
- Peter Fancsovits, Ph.D.
Infertility
Adding Cytokines to In Vitro Human Culture Media to Improve Embryogenesis and Implantation
Assessment of the embryological benefit of in vitro adding of Cytokines (LIF 5ng/ml, HB-EGF 5ng/ml and GM-CSF 2n/ml) to the culture media and closely monitor its effect on embryogenesis and implantation outcomes.
- Trial name
- GHLCSHED (NCT02420886)
- Testing
- Adding LIF, HB-EGF and GM-CSF to Lifeglobal human IVF culture media
- Where
- 2 sites in Egypt
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Frozen Embryo Transfer (FET)
Cryopreserved Pre-embryo Transfer in a Cytokine-rich Medium Versus Hyaluronic Acid
This multicenter, randomized, double-blind study compares a GM-CSF-enriched embryo transfer medium with a hyaluronic acid-enriched medium in women undergoing single frozen embryo transfer.
- Trial name
- CSF-EG (NCT07869576)
- Testing
- Cytokine-rich embryo transfer medium, Hyaluronic acid-enriched embryo transfer medium
- Volunteers
- 610 people
- Sponsor
- Vida Recoletas Sevilla
Embryonic Development, Infertility
Culture Media Microdroplet Geometry With Different Oil Overlay and Its Effect on Embryonic Development.
A prospective randomized study included 1695 MII sibling oocytes collected from 100 patients undergoing ICSI.
- Trial name
- NCT04485806
- Testing
- GPS/LM, SPL/LM, GPS/PO
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ganin Fertility Center
Infertility, Embryo Development
Use of G-CSF Supplemented IVF Medium in Patients Undergoing IVF
The purpose of this study is to determine whether in Assisted Reproductive Technologies the use of culture medium supplemented with G-CSF, a growth factor working on stem cells, may improve the embryo implantation and pregnancy…
- Conditions
- Infertility, Embryo Development, IVF
- Trial name
- NCT02651285
- Testing
- G-CSF medium, Control
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Centre for Endocrinology and Reproductive Medicine, Italy
Fertility
The Influence of Different Concentrations of Glucose in Culture Media on Fertilization and Embryo Quality
The aim of this study is to examine whether incubation of human oocytes until pronuclear stage, in different culture media containing high and low concentrations of glucose affect fertilization differently, not only in standard…
- Trial name
- NCT00606073
- Testing
- Universal IVF Medium + ISM1 Medium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Culture Media, Blastocyst
Comparisons of Human Embryonic Development Using Single Medium With and Without the Addition of Antioxidants
Aim: To investigate the impact of antioxidants (acetyl-L-carnitine, N-acetyl-L-cysteine and a-lipoic acid) on embryo development and subsequently the clinical outcome.
- Conditions
- Culture Media, Blastocyst, Antioxidants, Embryo
- Trial name
- NCT02971878
- Testing
- Acetyl-L-carnitine (ALC), N-acetyl-L-cysteine (NAC) and α-lipoic acid (ALA)
- Where
- Sweden
- Volunteers
- 128 people
- Sponsor
- Fertilitetscentrum AB
Culture Media, DNA
Cell-free DNA: a Non-invasive Test for Assessing Embryo Quality
In the present project we propose to deeply characterize nuclear and/or mitochondrial DNA in embryo culture medium, in order to investigate whether both cell-free nucleic acid types may provide additional, reliable, predictive…
- Trial name
- NCT01397136
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Infertility, Implantation Failure
ISM1 Versus EmbrioGen Media for Embryo Culture With Previous Failure Implantation in ART Treatments
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689454
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi
Culture, ICSI, IVF
Comparison of Two Embryo Culture Media for IVF and ICSI
In this research, the two media used are Global medium and SSM medium with serum), which are routinely used in the reproduction biology unit. This study simply consists in setting up a methodology to compare these to media.
- Trial name
- NCT02586324
- Testing
- global medium, SSM
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Chromosome Abnormalities, Genetic Diseases, Inborn
Utilizing Free DNA in Embryo Culture for PGT
In the way for developing and optimizing protocol to be used as non- invasive methodology used as routine testing for PGS. This protocol is to be adapted to replace the using of life embryo cells for genetic testing and…
- Conditions
- Chromosome Abnormalities, Genetic Diseases, Inborn, Mutation
- Trial name
- NCT02884063
- Testing
- NGS reading for Media Free DNA
- Volunteers
- 100 people
- Sponsor
- Al Baraka Fertility Hospital
in Vitro Fertilization
Embryo Transfer With Self-spent Culture Medium
Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the…
- Trial name
- NCT03728140
- Testing
- Self-spent Culture Medium
- Where
- China
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Bin Wu
Infertility, Infertility, Female
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells
To develop a deeper understanding of endometrial-embryo crosstalk through basic research, uncover therapeutic targets and to improve reproductive outcome.
- Conditions
- Infertility, Infertility, Female, Aneuploidy
- Trial name
- Ca2+ (NCT04865367)
- Testing
- Exposure to culture media
- Where
- United Arab Emirates
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Aneuploidy, Chromosome Abnormality
Multi-center Study to Validate niPGT-A
Abnormal chromosome number, or aneuploidy, is common in human embryos. It is responsible for more than half of all miscarriages, and it is the leading cause of congenital birth defects.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A (NCT03520933)
- Testing
- PGT-A, niPGT-A
- Where
- 10 sites in United States, Argentina and 6 more
- Volunteers
- 2,586 people
- Sponsor
- Igenomix
Infertility
Comparison of Human Embryo Development Using Sequential and Single Media With Time-lapse Imaging
The purpose of this study is to compare human embryo in vitro development in sequential and single-step culture medium using time-lapse imaging.
- Trial name
- NCT01939626
- Testing
- Single-step medium, Standard culture medium
- Where
- 4 sites in United States, Sweden
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vitrolife
Genetic Testing
Clinical Application of Non-invasive PGT-A
The study aims to investigate the difference of in vitro fertilization (IVF) outcomes among non-invasive PGT-A, PGT-A and combined non-invasive PGT-A and PGT-A.
- Trial name
- NCT04856696
- Testing
- PGT-A, non-invasive PGT-A
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Aneuploidy, Infertility
A Time-lapse Monitoring Prospective Study
While numerous types of commercially available human embryo culture media exist for human blastocyst culture, the impact of culture conditions on blastocyst development and aneuploidy formation is not fully understood.
- Trial name
- NCT04901247
- Testing
- media refreshment, embryo grading
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 50 people
- Sponsor
- ART Fertility Clinics LLC
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital