Clinical trials: Elevated Transaminases
Cryptogenic Hypertransaminasemia
Patients With Cryptogenic Hypertransaminasemia
Persistent unexplained elevation of serum aminotransferases (ALT and AST) remains undiagnosed in a subset of patients despite a comprehensive diagnostic work-up.
- Trial name
- LIFT (NCT07834125)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
MASH - Metabolic Dysfunction-Associated Steatohepatitis
Betaine vs. Placebo for Serologically Diagnosed Metabolic Dysfunction-associated Steatohepatitis (MASH)
The study will evaluate whether betaine reduces liver injury in people with metabolic dysfunction-associated steatohepatitis (MASH). MASH is a type of liver disease that occurs in some people with fatty liver.
- Trial name
- NCT07276204
- Testing
- Betaine
- Volunteers
- 70 people
- Sponsor
- Southern California Institute for Research and Education
Non-Alcoholic Fatty Liver Disease
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study
Over the past 30 years, the prevalence of childhood obesity in the United States has tripled from 5% to 15%. Major consequences of obesity include insulin resistance, type- 2 diabetes, cardiovascular disease and nonalcoholic…
- Trial name
- NCT01285362
- Testing
- Fish Oil Supplementation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Columbia University
Chronic Hepatitis C Virus Infection
Study of CTS-1027 in Hepatitis C Patients
The purpose of this study is to determine if CTS-1027 can lower elevated liver enzymes in patients with chronic HCV infection.
- Trial name
- NCT00570336
- Testing
- CTS-1027
- Where
- 19 sites in United States
- Volunteers
- 87 people
- Sponsor
- Conatus Pharmaceuticals Inc.
Chronic Hepatitis B
Tenofovir in Chronic Hepatitis B With Mild ALT Elevation
This study aims to clarify whether patients with chronic hepatitis B with high viral load will benefit from oral antiviral therapy despite only mildly elevated serum liver enzyme.
- Trial name
- NCT01522625
- Testing
- tenofovir disoproxil fumarate 300mg per day
- Where
- 6 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- E-DA Hospital
Chronic Hepatitis B
Evaluation of Chronic HBV Patients w/Evidence of HBV Replication and Normal or Minimally Elevated Liver Transaminases.
To determine whether HBeAg-positive and HBeAg-negative patients with HBV DNA greater than or less than 5 log10 and 4 log10 copies/mL, respectively, and with normal or minimally elevated liver transaminases have histological…
- Trial name
- NCT00263614
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Gilead Sciences
Metabolic Dysfunction-associated Fatty Liver Disease
Efficacy and Safety of Calculus Bovis Sativus in Adults With MAFLD
Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide. Timely therapeutic intervention for MAFLD is crucial for improving patient prognosis and preventing its…
- Trial name
- NCT07085962
- Testing
- Calculus bovis sativus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huazhong University of Science and Technology
Hepatitis C, Chronic
Safety And Efficacy Of Oral PF-4136309 In Patients With Chronic Hepatitis C Infection And Abnormal Liver Enzymes
This study will evaluate the effect of PF-04136309 in patients with chronic hepatitic C virus infection and abnormal liver enzymes.
- Trial name
- NCT01226797
- Testing
- PF-04136309
- Where
- 10 sites in Hong Kong, India and 3 more
- Volunteers
- 24 people
- Sponsor
- Pfizer
Elevated Alanine Transaminase (ALT)
ALT Routinely Recorded Remotely: A Comparator Study of Liver Function Tests Using the Tasso+ to Venipuncture.
A direct comparison study of blood samples collected using the Tasso+ device and venous blood samples in patients with elevated alanine transaminase (ALT).
- Trial name
- ARRR (NCT05259618)
- Testing
- Tasso+ SST
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Tasso Inc.
Non Alcoholic Fatty Liver Disease, Steatohepatitis
Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease
To explore whether there is a different response to omega-3 fatty acid rich diet with respect to the hepatic fat fraction % (HFF), triglyceride, and ALT levels between the rs738409 minor allele (GG) and the common allele…
- Conditions
- Non Alcoholic Fatty Liver Disease, Steatohepatitis, Hypertriglyceridemia, Alanine Aminotransferase, Plasma Level of, Quantitative Trait Locus 1
- Trial name
- NCT01556113
- Testing
- Omega diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Choledocholithiasis
The Clinical Characteristics of the Patients With Choledocholithiasis Without Cholangitis
Laboratory change induced by common bile duct (CBD) stone is in general observed as the higher elevation of alkaline phosphatase (ALP) and gamma-glutamyl transpeptideas (ɤ-GT), in comparison to those of aspartate aminotransferase…
- Trial name
- NCT02647593
- Volunteers
- 44 people
- Sponsor
- Gangnam Severance Hospital
Elevated Alanine Aminotransferase, Postpartum Chronic Hepatitis B Mothers
Incidence and Predictors of Elevated ALT in Postpartum CHB Mothers
China currently has about 86 million people with chronic hepatitis B virus infection, and infections caused by mother-to-child transmission account for 40% to 50% of new hepatitis B infections.
- Trial name
- NCT07533929
- Volunteers
- 352 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Chronic Hepatitis B, Pregnancy Complications
Efficacy, Safety and Tolerability of Telbivudine in HBeAg Positive Chronic Hepatitis B Pregnant Women With Elevated Alanine Aminotransferase Levels
Telbivudine reduces DNA and normalizes alanine aminotransferase levels (ALT) in chronic hepatitis B patients with few adverse effects, but its use during pregnancy has not been explored.
- Conditions
- Chronic Hepatitis B, Pregnancy Complications, High Viral Load, Elevated Alanine Aminotransferase Levels
- Trial name
- NCT01337791
- Testing
- Telbivudine treatment
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Southeast University, China
Liver Fibrosis, Steatohepatitis
Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
This study will provide a basis for research on the impact of liver injury caused by antiretroviral therapy in HIV-infected patients.
- Conditions
- Liver Fibrosis, Steatohepatitis, Elevated Transaminases
- Trial name
- NCT00326482
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemolytic Disorders, Gallstones
The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders
It is well established that hemolytic diseases predispose patients to the development of pigment gallstones. Gallstones are noted in at least 5% of children under the age of 10 years, increasing to 40-50% in the second to fifth…
- Trial name
- NCT02472509
- Testing
- Ursodeoxycholic Acid
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Shaare Zedek Medical Center
Visceral Fat, Liver Dysfunction
Weight Loss Effect on Circulating Liver Enzymes
To investigate weight loss effect with mild calorie restriction on circulating levels of liver enzymes in nondiabetic and overweight subjects with high visceral fat area [visceral fat area (VFA) at L4 ≥ 100 cm²].
- Trial name
- NCT02992639
- Testing
- Control group, Weight loss group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Primary Biliary Cholangitis
The Comparison About the Response of Ursodeoxycholic Acid in Primary Biliary Cholangitis Only and Primary Biliary Cholangitis With High Immune Globulin G or Aminotransferase at West China Hospital
This study evaluates the different response of Ursodeoxycholic Acid in primary biliary cholangitis only and primary biliary cholangitis with high immune globulin G or aminotransferase at West China Hospital from 2008-2017.
- Trial name
- NCT03322943
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Hepatitis B
A Study to Compare Efficacy and Safety of Tenofovir Used Alone or in Combination With Pegylated Interferon Alpha-2b in Participants With Chronic Hepatitis B and Elevated Alanine Aminotransferase (MK-4031-384)
This study will compare monotherapy with tenofovir to sequential therapy with pegylated interferon alpha-2b (pegIFN-2b) followed by tenofovir, and to combination therapy with pegIFN-2b + tenofovir, in participants with hepatitis…
- Trial name
- NCT01727271
- Testing
- Tenofovir, Pegylated interferon alpha-2b
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Liver Disease
To Evaluate the Efficacy of DDB/Garlic Oil in Patients With Elevated Transaminase Chronic Liver Disease
Purpose To evaluate the efficacy of Biphenyl dimethyl dicarboxylate(DDB)/Garlic Oil in patients with elevated transaminase chronic liver disease.
- Trial name
- NCT02347319
- Testing
- Pennel, Legalon
- Where
- South Korea
- Volunteers
- 262 people
- Sponsor
- PharmaKing
Chronic Hepatitis B, Antiviral Treatment
Roll-over After 3-year Trial for Tenofovir in Mild Chronic Hepatitis B
This open-label study is an roll-over extension of a randomized trial "Efficacy of Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients with High Viral Load but Slight Aminotransferase Elevation" (NCT01522625).
- Trial name
- NCT02463019
- Testing
- Tenofovir Disoproxil Fumarate
- Volunteers
- 160 people
- Sponsor
- E-DA Hospital