Clinical trials: Elevated Intraocular Pressure (IOP)
Open-angle Glaucoma, Oular Hypertension
Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to evaluate the safety and intraocular-lowering efficacy of anecortave acetate depot when administered by anterior juxtascleral depot (AJD) for the treatment of elevated intraocular pressure (IOP) in…
- Trial name
- NCT00691717
- Testing
- Anecortave Acetate Sterile Suspension, 30 mg/mL, Anecortave Acetate Sterile Suspension, 60 mg/mL, Anecortave Acetate Sterile Suspension, 75 mg/mL
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Alcon Research
Glaucoma, Glaucoma, Open Angle
SOLX Gold Shunt for Refractory Glaucoma
To establish the clinical performance of the SOLX Gold Shunt for its ability to reduce intraocular pressure (IOP) in eyes with refractory glaucoma where medical and conventional surgical treatments have failed.
- Trial name
- NCT01282346
- Testing
- SOLX Gold Shunt
- Where
- 17 sites in United States, Brazil and 3 more
- Volunteers
- 116 people
- Sponsor
- SOLX, Inc.
Glaucoma
Sleep at 30 Degrees in Glaucoma
This study is designed to investigate the effect of body posture (particularly when sleeping) on the pressure in the eye. The effect of body posture on progressive glaucoma (glaucoma where a significant change i.e.
- Trial name
- NCT00802061
- Testing
- Sleeping position in glaucoma patient
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Open-angle Glaucoma
Dose, Effects and Characteristics of Pilocarpine
The purpose of this investigation, in which pilocarpine was given in repeated doses, was to evaluate: Part I - the effects of different concentrations of pilocarpine hydrochloride on intraocular pressure.
- Trial name
- NCT00803803
- Testing
- Pilocarpine Concentration, Pilocarpine Frequency
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Wills Eye
Primary Open Angle Glaucoma, Ocular Hypertension
Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension
The purpose of this study is to evaluate and compare efficacy and tolerability of the brand-name latanoprost and one of its generic version in subjects with primary open angle glaucoma or ocular hypertension.
- Trial name
- NCT02047630
- Testing
- Generic latanoprost, Brand-name latanoprost
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- CHU de Quebec-Universite Laval
Pseudoexfoliation Glaucoma, Primary Open-angle Glaucoma
Micropulse Laser Trabeculoplasty as Adjunctive Treatment in Patients With Pseudoexfoliation Glaucoma
This study aims to evaluate the effect of a single session of micropulse laser trabeculoplasty (MLT) on cornea in eyes with primary open glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG).
- Trial name
- NCT03483402
- Testing
- Micropulse laser trabeculoplasty
- Volunteers
- 27 people
- Sponsor
- University Hospital of Patras
Intraocular Pressure, Glaucoma
iCare HOME2 Clinical Trial
The aim of this clinical study is to provide information about the variability of the intraocular pressure (IOP) self-measurements with the iCare HOME2 tonometer in comparison to the variability of the IOP measurements with the…
- Trial name
- NCT05162989
- Testing
- iCare HOME2 vs iCare IC200
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icare Finland Oy
Childhood Glaucoma
Efficacy and Safety of Topically Applied Medical Therapy for the Treatment of Pediatric Glaucoma
Objectives: The study will assess the ocular hypotensive effect of latanoprost and dorzolamide in a selected sample of patients affected by primary Pediatric Glaucoma (PG), refractory to surgical procedures.
- Trial name
- NCT01527682
- Testing
- Latanoprost, Dorzolamide
- Where
- 2 sites in Italy
- Volunteers
- 37 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Study of Bimatoprost, Latanoprost, and Travoprost in Patients With Elevated Intraocular Pressure (IOP) and Open-angle Glaucoma (OAG)
To investigate the effectiveness of the newer IOP-lowering therapies, as prescribed in normal clinical practice, in larger patient numbers.
- Trial name
- NCT00716742
- Testing
- bimatoprost 0.03%, latanoprost 0.005%, and travoprost 0.004%
- Where
- United States
- Volunteers
- 1,099 people
- Sponsor
- Allergan
Open-angle Glaucoma, Ocular Hypertension
Adherence Assessment With Travalert Dosing Aid
The purpose of the study is to compare adherence in patients on a fixed combination of travoprost 0.004%/timolol 0.5% and patients on a concomitant combination of travoprost 0.004% and timolol 0.5% using the Travalert® device.
- Trial name
- NCT00508469
- Testing
- Travoprost 0.004%/timolol 0.5% fixed combination eye drops (DuoTrav), Travoprost 0.004% eye drops, Timolol 0.05% eye drops
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Alcon Research
Physiology
Effects of Intravenous Clonidine on Ocular Blood Flow and Intraocular Pressure
Background Clonidine, a derivate of Imidazol, is an antihypertensive drug. It acts by stimulating adrenergic receptors on nerves in the brain and Imidazol-receptors.
- Trial name
- NCT00279253
- Testing
- clonidine (drug) intravenously
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
The Effect of Education on Patient Compliance
With patient education, the compliance with glaucoma medications will increase.
- Trial name
- NCT00376974
- Testing
- American Academy of Ophthalmology Glaucoma Educational Tape
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Glaucoma
Steroids Versus Non-steroidal Anti-inflammatory Drugs Following Glaucoma Surgery
This study aims to evaluate the eye pressure response to non-steroidal anti-inflammatory eye drops as compared to steroid eye drops following glaucoma surgery.
- Trial name
- NCT00956462
- Testing
- Ketorolac (NSAID) versus Dexamethasone (steroid)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University Health Network, Toronto
Glaucoma
Clinical Application of Sensimed Triggerfish Sensor (TS) With Wireless Signal Transmission for Continuous Intraocular Pressure Measurement
The study objective is to investigate the clinical applicability of continuous IOP measurement using TS with radio transmission over 24 hours. Trial with medical device
- Trial name
- NCT01467453
- Testing
- Triggerfish
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Primary Open-angle Glaucoma
SIGHT Study: Cost-effectiveness of InnFocus Microshunt Implantation vs. Trabeculectomy.
The standard surgical treatment for glaucoma is trabeculectomy. The PRESERFLO™ (formerly InnFocus) Microshunt (IMS) is a new, minimally invasive drainage device which has been suggested to result in similar IOP lowering, but with…
- Trial name
- SIGHT (NCT03931564)
- Testing
- PRESERFLO Microshunt implantation, Trabeculectomy
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Open-Angle Glaucoma, Ocular Hypertension
A Dose-Volume Study of a Treatment for Elevated IOP Due to Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to assess the effects of total volume and total dose on the safety and intraocular pressure-lowering efficacy of Anecortave Acetate Suspension (3 mg and 48 mg) in 0.5 mL and 0.8 mL volumes when…
- Trial name
- NCT00788541
- Testing
- Anecortave Acetate Sterile Suspension, 6 mg/mL, Anecortave Acetate Sterile Suspension, 3.75 mg/mL, Anecortave Acetate Sterile Suspension, 96 mg/mL
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Alcon Research
Neovascular Glaucoma
Comparative Study, Safety and Efficacy, Ahmed Glaucoma Drainage Device, Model M4 Model S2 in Neovascular Glaucoma
Objective: Prospectively evaluate the safety and efficacy of the Ahmed Glaucoma Drainage Device, model M4 compared with the model S2.
- Trial name
- NCT02260219
- Testing
- Surgical Implant of Ahmed Glaucoma Drainage Device, model M4 and S2
- Volunteers
- 42 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Glaucoma
12-Month Stability of Diurnal IOP Control on Cosopt
To determine the stability of diurnal intraocular pressure in eyes with glaucoma treated with Cosopt
- Trial name
- NCT00379834
- Testing
- Cosopt
- Volunteers
- 10 people
- Sponsor
- West Virginia University
Glaucoma, Cataract
Effect of Elevated Intraocular Pressure in Glaucoma Patients During Femtolaser Cataract Surgery
The use of the femtosecond laser causes an increase in the intraocular pressure (IOP) between 100 mm Hg and 200 mm Hg for a period of about 80 seconds (suction phase).
- Trial name
- FEMTOHTO (NCT02835482)
- Testing
- Femtolaser surgery, Phacoemulsification
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University