Clinical trials: Elderly Patients
Depression, Dementia
Prognosis of Depression in the Elderly (PRODE). A Multicentre, Longitudinal Study of Elderly Depressed Patients.
PRODE is a Norwegian multicentre study investigating the prognosis of depression in the elderly. The study has included 169 patients who will be followed with assessments after one and three years.
- Trial name
- PRODE (NCT01952366)
- Where
- Norway
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Sykehuset Innlandet HF
Postoperative Delirium, Hip Fractures
Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery
Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing surgical repair for hip fractures, often triggered by acute pain, surgical stress, neuroinflammation, and opioid consumption.
- Trial name
- NCT07810556
- Testing
- Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline
- Volunteers
- 130 people
- Sponsor
- Assiut University
Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment
Diabetes as an Accelerator of Cognitive Impairment and Alzheimer's Disease
This randomized controlled trial is aimed at studying the effects of an eHealth intervention on improving metabolic control and other cardiovascular risk factors (obesity, lipidic profile and hypertension) as the approach to…
- Conditions
- Patients Aged 65-85 (Both Included), Diagnosed of Mild Cognitive Impairment, Diagnosed of Type 2 Diabetes in Active Treatment (Hypoglycemic Agents) for a Period ≥5 Years
- Trial name
- DIALCAT (NCT03578991)
- Testing
- Smart pillbox, Interactive digital platform
- Where
- 8 sites in Spain
- Volunteers
- 54 people
- Sponsor
- Parc Sanitari Pere Virgili
Postoperative Neurocognitive Disorders
Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients
Postoperative neurocognitive disorders (PND) are common postoperative complication of central nervous system, leading to increased risk of the working ability loss after surgery, longer hospital stay, increased medical costs and…
- Trial name
- NCT05613491
- Testing
- Intranasal insulin, Intranasal saline
- Where
- China
- Volunteers
- 438 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Elderly Person, Comfort
Effect of Care Provided Through Skin Care Protocol on Elderly Patients
The rate of elderly population is increasing in the world. It is reported that the proportion of the world population over the age of 60 will increase to 22% by 2050.
- Conditions
- Elderly Person, Comfort, Quality of Life, Skin Moisture
- Trial name
- NCT06462690
- Testing
- pre-mid-post test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Duygu AKÇA
Geriatric Assessment, Cancer
Effect of Comprehensive Geriatric Assessment on Short-time Mortality in Elderly Cancer Patients
Older cancer patients referred to Oncology outpatient Clinic at Aarhus University Hospital have for a period been offered Comprehensive geriatric Assessment (CGA) as part of a routine practice.
- Trial name
- NCT03814213
- Testing
- CGA, tailored care
- Where
- 2 sites in Denmark
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Patient Discharge
Discharge Planning for Elderly Patients in the Emergency Department: Use of a Brief Phone Call After Discharge to Improve Medication Utilization and Physician Follow-up
The investigators hypothesize that the acquisition and correct utilization of medications as well as arranging and attending follow-up appointments will improve as a result of a phone call intervention 1-3 days after elderly…
- Trial name
- NCT01207180
- Testing
- Phone call follow-up, Satisfaction survey, Control group --- no intervention
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- University of North Carolina, Chapel Hill
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Toripalimab Plus Rituximab Followed by R-CHOP for Elderly Patients With Untreated Diffused B Cell Lymphoma
1. Phase I portion of this study will evaluate the efficacy and saftey of toripalimab plus rituximab in treating untreated elderly diffuse large B cell lymphoma patients. 2.
- Conditions
- Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma Grade IIIb, Transformed Lymphoma
- Trial name
- NCT04058470
- Testing
- Toripalimab, Rituximab, R-CHOP Protocol
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Huiqiang Huang
Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8
Platinum-Based Chemotherapy and Durvalumab for the Treatment of Stage IIIB or IV Non-small Cell Lung Cancer
This phase II trial studies how well platinum-based chemotherapy works when given together with durvalumab in treating patients with stage IIIB or stage IV non-small cell lung cancer.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8
- Trial name
- NCT04262869
- Testing
- Carboplatin, Durvalumab, Paclitaxel
- Sponsor
- Emory University
Respiratory Aspiration, Hyperglycemia
Maltodextrin Versus Sugar Water Carbohydrate Loading and Gastric Volume in Geriatric Lower Limb Orthopedic Surgery
Before surgery, patients are asked to fast so the stomach is empty and stomach contents cannot enter the lungs during anesthesia. Long fasting is uncomfortable and can raise blood sugar and stress responses in older adults.
- Conditions
- Respiratory Aspiration, Hyperglycemia, Inflammation
- Trial name
- CHO-GERIGAS (NCT07872683)
- Testing
- Maltodextrin carbohydrate drink, Sugar water
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
High Grade Lymphomas CD20 Positive
Phase I/II Study of Escalating Doses of Idarubicin Orally Given With Oral Cyclophosphamide, Etoposide, Prednisolone and Intravenous Rituximab in Elderly Patient With Disseminated High Grade Non Hodgkin Lymphoma
R-CHOP with doxorubicin is the standard first line treatment of high grade non-Hodgkin's lymphoma. In order to avoid central venous system insertion and reduce hospitalization time in elderly patients, we developed an oral…
- Trial name
- NCT01958996
- Testing
- idarubicin
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Poitiers University Hospital
Ovarian Cancer, Breast Cancer
Comprehensive Outcomes for After Cancer Health
This study intends to explore feasibility, acceptability, and outcomes related to the use of a digital health coaching intervention for individuals who have completed primary therapy for cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Lung Cancer, Gastric Cancer
- Trial name
- COACH (NCT05349227)
- Testing
- Digital Health Coaching Program, Fitbit
- Where
- 7 sites in United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Pack Health
Gingivitis
Silver Diamine Fluoride and Gingivitis in Geriatric Patients
Gingivitis in the geriatric population is one of the growing global public health concerns, thus finding the most effective and non-invasive approach to prevent and treat gingivitis in the geriatric population is essential to…
- Trial name
- NCT03445286
- Testing
- Silver Diamine Fluoride, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Texas A & M University Baylor College Of Dentistry
Chronic Renal Failure, Hip Fracture
Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery
Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an increased risk of cardiovascular comorbidity.
- Trial name
- NCT01837290
- Testing
- dexmedetomidine infusion for premedication, Midazolam, saline infusion
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Infection, Acute Coronary Syndrome
Association Between Levels of D-Dimer, Fibrinogen and PAI-1 in Elderly Patients With Infection and Occurrence of Cardio- and Cerebro-vascular Disease After Discharge
The association between the levels of d-dimer, fibrinogen and PAI-1 in plasma of elderly patients admitted to internal medicine departments because of infection and the occurrence of cardio- and cerebro-vascular disease after…
- Conditions
- Infection, Acute Coronary Syndrome, Cerebrovascular Disease
- Trial name
- NCT00512603
- Volunteers
- 52 people
- Sponsor
- Wolfson Medical Center
Glioblastoma, Malignant Glioma
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy
This phase II trial studies how well fluorodopa F 18-positron emission tomography/magnetic resonance imaging scan (18F-DOPA-PET/MRI) works in imaging elderly patients with newly diagnosed grade IV malignant glioma or glioblastoma…
- Trial name
- NCT03778294
- Testing
- Computed Tomography, Fluorodopa F 18, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Delirium
Comparative Analysis of Delirium in Older Adults Treated With Ceftazidime, Cefepime, or Ceftriaxone
The goal of this observational study is to learn if the use of ceftazidime, cefepime, and ceftriaxone impacts the incidence of delirium in elderly patients (aged 65 and older) with infections.
- Trial name
- CAD-CEF (NCT07026253)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Limb Injury, Older Adults
Geriatric Trauma Care Program for Living Alone Older Adults With Injuries
To examine the long-term effects of the Geriatric Trauma Care Program (GTCP) regarding pain, functional disability, depression, loneliness, and health-related quality of life among older adults with traumatic injuries who live…
- Conditions
- Limb Injury, Older Adults, Geriatric, Pain
- Trial name
- NCT06902636
- Testing
- Geriatric trauma care program
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Medical University
Adult Acute Lymphocytic Leukemia
Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia
The aim of this study is to test feasibility and efficacy of a dose reduced chemotherapy in elderly patients with newly diagnosed acute lymphoblastic leukemia.
- Trial name
- NCT00199095
- Testing
- Adriamycin, Cyclophosphamide, Cytarabine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Goethe University
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