Clinical trials: Early Stage Lung Cancer
Lung Cancer
Biomarkers in Predicting Response in Patients With Early-Stage Non-Small Cell Lung Cancer Previously Treated With Adjuvant Chemotherapy
This research trial studies prognostic and predictive markers in patients with early stage non-small cell lung cancer receiving chemotherapy.
- Trial name
- NCT01294280
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma
Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer
This phase I/II trial studies the side effects of bomedemstat and maintenance immunotherapy with atezolizumab and to see how well they work in treating patients with newly diagnosed extensive stage small cell lung cancer.
- Trial name
- NCT05191797
- Testing
- Bomedemstat, Atezolizumab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Washington
Lung Neoplasms
Does Intense Regimented Surveillance Improve the Rates of Therapeutic Re-Intervention After Lung Cancer Surgery
After curative lung cancer surgery, there is a risk of recurrence of the primary cancer, or development of a new cancer. Historically, patients who have undergone curative lung cancer surgery have been monitored with chest…
- Trial name
- Intense-CT (NCT02149576)
- Testing
- Low Dose Computed Tomography Imaging, Chest Radiograph Imaging
- Where
- Canada
- Volunteers
- 313 people
- Sponsor
- McMaster University
Carcinoma, Non-Small-Cell Lung
Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative Gemcitabine-Cisplatin in Clinical Early Stages of Non-small Cell Lung Cancer
Randomized Phase III trial of surgery alone or surgery plus preoperative Gemcitabine-Cisplatin in clinical early stages of non-small cell lung cancer
- Trial name
- NCT00540280
- Testing
- Surgery alone or surgery plus preoperative Gemcitabine-Cisplatin
- Volunteers
- 10 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Carcinoma, Non-Small-Cell Lung
Erlotinib and Sequential Positron Emission Tomography (PET) in Advanced Non Small Cell Lung Cancer (NSCLC)
This is a Phase-II Study to evaluate the accuracy of Fluorodeoxyglucose-/Fluorothymidine-Positron Emission Tomography (FDG-/FLT-PET) analyses for early prediction of non-progression in patients with non-small-cell lung cancer…
- Trial name
- ERLOPET (NCT00568841)
- Testing
- erlotinib, FDG-/FLT-PET
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Lung Cancer Group Cologne
Lung Cancer
Treatment of Early Stage Lung Cancer by VATS Versus OPEN Lobectomy
In patients with early stage lung cancer surgical lobectomy is the treatment of choice. A resection by Video-assisted Thoracic Surgery (VATS) is probably superior to an open procedure by thoracotomy for patients with early stage…
- Trial name
- SCOPE (NCT01933828)
- Testing
- OPEN lobectomy, VATS lobectomy, ROBOT-assisted lobectomy
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Radboud University Medical Center
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 751 sites in United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Non-small Cell Lung Cancer
Cryoablation with or Without Serplulimab in Treating Patients with Stage I-IIA Non-small Cell Lung Cancer
Cryoablation is a minimally invasive technique that utilizes very low temperature to eliminate tumour cells for patients ineligible for surgery.
- Trial name
- NCT06580665
- Testing
- Cryoablation, Serplulimab
- Where
- 5 sites in China
- Volunteers
- 134 people
- Sponsor
- Shanghai Chest Hospital
Advanced Non-small Cell Lung Cancer (NSCLC)
Impact of Liquid Biopsy on the Therapeutic Pathway for Lung Cancer: Advancing the Molecular Characterization of Patients With Advanced Lung Adenocarcinoma by Integrating Liquid Biopsy Into the Early Stages of the Diagnostic and Therapeutic Pathway
This multicenter pilot observational study aims to assess the feasibility of introducing liquid biopsy at an early stage of the diagnostic pathway for patients with suspected advanced non-small cell lung cancer (NSCLC).
- Trial name
- INNOVA-LUNG (NCT07649629)
- Testing
- Plasma-based liquid biopsy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Regina Elena Cancer Institute
Small-Cell Lung Cancer
Early Hippocampal Avoidance Prophylactic Cranial Irradiation in Patients With LD SCLC
The main objective of this trial is to assess NCF after early HA-PCI concomitant to the second cycle of CHT and to tRT for patients with LD SCLC.
- Trial name
- NCT02058056
- Testing
- Irradiation: HA-PCI
- Where
- 8 sites in Switzerland
- Volunteers
- 44 people
- Sponsor
- Swiss Cancer Institute
Small Cell Lung Cancer
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Researchers are looking for new ways to treat Limited-Stage Small Cell Lung Cancer (LS-SCLC), a type of lung cancer that has not spread from the lung to other parts of the body.
- Trial name
- NCT04624204
- Testing
- Pembrolizumab 200 mg, Pembrolizumab 400 mg, Olaparib 300 mg BID
- Where
- 187 sites in United States, Australia and 23 more
- Volunteers
- 672 people
- Sponsor
- Merck Sharp & Dohme LLC
Lung Cancer
Bevacizumab, Cisplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some find tumor cells and help kill them or carry tumor-killing substances to them.
- Trial name
- NCT00387699
- Testing
- bevacizumab, cisplatin, etoposide
- Volunteers
- 79 people
- Sponsor
- Eastern Cooperative Oncology Group
Early Stage Non-small Cell Lung Cancer
Predicting Cell Death by Radiation Therapy in Early Stage Non-small Cell Lung Cancer: a Prospective Translational Trial
Surgical resection with mediastinal lymph node sampling is currently the therapy of choice for early stage (I-II) non-small cell lung cancer (NSCLC).
- Trial name
- PEARL-1 (NCT01138722)
- Testing
- hypofractionated radiation therapy followed by surgery
- Where
- 2 sites in Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Non Small Cell Lung Cancer
Neoadjuvant Afatinib in Early Stage Non Small Cell Lung Cancer.
This is a multicenter, randomized, 1:1, non-comparative phase II trial. Patients with early stage NSCLC will be randomized between ARM A: neoadjuvant afatinib followed by surgery and ARM B: immediate surgery with curative intent.
- Trial name
- REMNANT (NCT02470065)
- Testing
- Afatinib, Immediate surgery
- Volunteers
- 38 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lung Cancer (NSCLC)
Percutaneous Pulsed Electric Field Ablation for Early-Stage NSCLC and Lung Oligometastases: A Safety and Efficacy Study
The goal of this observational study is to evaluate the performances of a percutaneous Pulsed Electrical Field (PEF) ablation to treat patients with primary early-stage lung cancer (NSCLC) or lung oligometastatic Tumors who are…
- Trial name
- NCT07799194
- Testing
- Pulsed Electric Field Ablation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Energenx Medical LTD.
Non Small Cell Lung Carcinoma, Stage I
Anti PD-1 Neo-adjuvant Treatment for NSCLC
A single arm, phase I, dose escalation trial and expansion cohort, examining the safety and feasibility of neoadjuvant pembrolizumab treatment for early resectable NSCLC patients.
- Conditions
- Non Small Cell Lung Carcinoma, Stage I, Stage II
- Trial name
- MK3475-223 (NCT02938624)
- Testing
- Pembrolizumab 200 mg IV single dose, Pembrolizumab 200 mg IV twice interval 21 days, Pembrolizumab 200 mg IV Twice interval 21d,surgery after 10d
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Jair Bar, M.D., Ph.D.
Lung Cancer
Trial of Either Surgery or Stereotactic Radiotherapy for Early Stage (IA) Lung Cancer
The standard treatment for an early stage I lung cancer is surgery. However, surgery can be associated with complications and long-term impairment of the quality of life of patients.
- Trial name
- ROSEL (NCT00687986)
- Testing
- stereotactic radiotherapy, primary surgery
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Amsterdam UMC, location VUmc
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Small Cell Lung Cancer Limited Stage
Chemoradiotherapy With or Without Sintilimab in Limited-stage SCLC
The study is a prospective, multi-center, open-label, randomized, and controlled phase II clinical trial.
- Trial name
- NCT04189094
- Testing
- Sintilimab, Etoposide, Cisplatin
- Volunteers
- 140 people
- Sponsor
- Zhejiang Cancer Hospital
Non-small Cell Lung Cancer
A Study to Evaluate Effectiveness and Safety of Surgeries in Elderly NSCLC Patients
The trial was designed to compare effectiveness and safety of surgeries in the patients with non-small cell lung cancer
- Trial name
- NCT03429673
- Testing
- Surgeries
- Where
- 10 sites in China
- Volunteers
- 10,885 people
- Sponsor
- China-Japan Friendship Hospital