Clinical trials: Early Lung Cancer Detection
Pulmonary Nodules, Early Detection of Cancer
Diagnostic Performance of an AI-Based Multi-Omics Model for Early Lung Cancer
This is a prospective, multicenter observational cohort study for patients with lung nodules suspicious for early-stage lung cancer.
- Conditions
- Pulmonary Nodules, Early Detection of Cancer, Lung Neoplasms
- Trial name
- NCT07882628
- Where
- 8 sites in China
- Volunteers
- 1,050 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Cancer Screening, Lung Neoplasms
Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)
Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it.
- Conditions
- Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer
- Trial name
- Empower LCS+ (NCT07711691)
- Testing
- Empower LCS, Call+ Telephone Navigation, Usual Care
- Where
- 57 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Lung Neoplasms, Stomach Neoplasms
Default Option Nudging Intervention to Improve the Adherence Rates of Cancer Screening
The goal of this clinical trial is to learn if a behavioral "nudge" strategy, specifically a default option, can improve screening participation in populations at high risk for lung and stomach cancer.
- Conditions
- Lung Neoplasms, Stomach Neoplasms, Early Detection of Cancer, Patient Compliance
- Trial name
- NCT07682220
- Testing
- Default Options
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
Lung Cancer, Early Lung Cancer Detection
CHAMP Lung Cancer Screening Program
The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) with low-dose CT for adults aged 50-80 with a ≥20 pack-year smoking history who currently smoke or quit within the past 15 years.
- Trial name
- CHAMP (NCT07572773)
- Testing
- DELFI Diagnostics FirstLook Lung Cancer Screening Blood Test, Low-Does CT Scan
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Jill Kolesar
Lung Cancer, Health Screening
Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT
The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation.
- Conditions
- Lung Cancer, Health Screening, Early Cancer Detection, Deep Learning
- Trial name
- NCT06910956
- Testing
- CXR-LC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Massachusetts General Hospital
Cancer, Cancer Diagnosis
Avera Cancer Sequencing and Analytics Protocol (ASAP)
The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system.
- Conditions
- Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer
- Trial name
- ASAP (NCT05142033)
- Where
- 6 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Lung Cancer, Lung Neoplasms
Liquid Biopsy-Based Pre-Screening to Streamline LDCT Lung Cancer Screening in High-Risk Individuals
This study evaluates the feasibility and cost-effectiveness of using a blood-based liquid biopsy assay as a pre-screening tool before low-dose CT (LDCT) for lung cancer screening.
- Conditions
- Lung Cancer, Lung Neoplasms, Early Lung Cancer Detection, Cancer Screening
- Trial name
- NCT07358715
- Testing
- Liquid Biopsy (SPOT-MAS Assay), Exosome-Based Liquid Biopsy Assay, Low-Dose CT Thorax (LDCT)
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Lung Nodules, Lung Cancers
Assessing AI for Detecting Lung Nodules and Cancer: Pre- and Post-Deployment Study
The study evaluates the impact of qXR-LN compared to standard radiologist-only interpretations before and after AI deployment. The goal is to compare how well lung nodules and cancers are detected in two time periods: before and…
- Conditions
- Lung Nodules, Lung Cancers, Early-Stage Lung Cancer, Artificial Intelligence in Radiology
- Trial name
- AI-Lung (NCT06746324)
- Sponsor
- University of Florida
Early Detection of Cancer, Lung Neoplasms
Evaluation of a Scalable Decision Support and Shared Decision Making Tool for Lung Cancer Screening
The purpose of this project is to increase appropriate low-dose computed tomography (LDCT) lung cancer screening through the development and wide dissemination of patient-centered clinical decision support (CDS) tools that (1)…
- Trial name
- NCT04498052
- Testing
- EHR-integrated Shared Decision Making Tool and Clinical Decision Support for Lung Cancer Screening
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- University of Utah
Adenocarcinoma of Lung; Bronchial Neoplasms; Early Detection of Cancer; Machine Learning
Early Detection of Lung Cancer With Machine Learning Based on Routine Clinical Investigations
This observational, cross-sectional study in lung cancer patients and lung cancer-free controls aims to develop a machine learning model for early detection of LC based on routine, widely accessible and minimally invasive…
- Trial name
- NCT05907577
- Testing
- Observational
- Where
- 2 sites in Slovenia
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- The University Clinic of Pulmonary and Allergic Diseases Golnik
Early Detection of Cancer, Lung Cancer
Improving Implementation of Lung Cancer Screening in Diverse Populations II
This project assesses the feasibility, appropriateness, and acceptability of a "Commonly Asked Questions after Lung Cancer Screening" (CAQ) informational document that the investigators created, resulting from patient and…
- Trial name
- NCT05265897
- Testing
- CAQ
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- University of Washington
Lung Neoplasms, Early Detection of Cancer
Pre-Post Study for Supporting Appropriate Implementation of Lung Cancer Screening
The primary objective of this study is to assess the effect of the decision aid on measures of decision-making such as knowledge, screening attitudes, decisional conflict, and screening intent.
- Conditions
- Lung Neoplasms, Early Detection of Cancer, Decision Support Techniques, Primary Health Care
- Trial name
- NCT03077230
- Testing
- Pre/Post Test of a Lung Cancer Screening Decision Aid
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center