Clinical trials: Early Glottic Cancer
Head and Neck Cancers, Laryngeal Carcinoma
Telemedicine Follow-Up for Early Laryngeal Cancer: a Randomized Controlled Trial Comparing Care Close to Home Versus Standard of Care
The goal of this clinical trial is to evaluate whether Telemedicine follow-up is a satisfactory and safe alternative to traditional follow-up care for patients treated for early glottic (vocal cord) cancer, particularly those who…
- Trial name
- Telemedicine (NCT06940505)
- Testing
- Telemedicine Follow-up
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University Medical Center Groningen
Early-stage Glottic Larynx Cancer
CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer
The feasibility of reducing fractions in early-stage laryngeal cancer has not previously been prospectively studied, and we will therefore conduct a careful phase I bio-equivalent dose fraction reduction study.
- Trial name
- NCT01984502
- Testing
- CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Carcinoma of Glottis
Quality of Life After Laser Cordectomy in Early Glottic Cancer
Laryngeal cancer is common in the Taiwanese populations. Before early 80's, open laryngectomy was the suggested treatment modality for laryngeal cancer.
- Trial name
- NCT02184403
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Chang Gung Memorial Hospital
Glottic Carcinoma
Volumetric Adaptive SBRT Versus Conventional Accelerated Radiation Therapy for Early-Stage Glottic Cancer
This non-inferiority trial will compare conventional long-course accelerated fractionation radiation therapy (AF-RT) with volumetric adaptive stereotactic body radiation therapy (SBRT) in patients with early-stage (cT1-2N0M0)…
- Trial name
- VOICE (NCT07895745)
- Testing
- Long course accelerated fractionation radiation therapy, Adaptive stereotactic body radiation therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Laryngeal Neoplasm, Glottic Carcinoma
Precision Medicine: MRI-Guided Stereotactic Ablative Radiotherapy (MRI-SABR) for Early-Stage Glottic Laryngeal Cancer
This randomized phase III trial will compare the outcomes of three treatment modalities for early-stage glottic laryngeal cancer (T1-T2N0): transoral CO₂ laser microsurgery (TLM), volumetric modulated arc therapy (VMAT), and…
- Trial name
- SMART - 1_1 (NCT07391345)
- Testing
- Transoral CO₂ laser cordectomy (Type I-VI depending on tumor localization), VMAT radiotherapy, MRI-SABR
- Where
- Lithuania
- Volunteers
- 105 people
- Sponsor
- Viktoras Rudzianskas
Glottic Carcinoma
Stereotactic Ablative Radiotherapy for Early-stage Glottic Larynx Cancer
This is a prospective study to determine the local control and quality-of-life outcomes of using SBRT for early-stage glottic larynx cancer.
- Trial name
- NCT03548285
- Testing
- Radiation therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
Cancer Neck, Larynx Cancer
Vocal-cord vs. Complete Laryngeal Radiotherapy for Early Glottic Cancer
This is a multicentrer, randomized Bayesian Phase II trial for patients with early stage (T1N0) glottic squamous cell carcinoma treated with radical radiotherapy.
- Conditions
- Cancer Neck, Larynx Cancer, Glottis Tumor
- Trial name
- VOCAL (NCT03759431)
- Testing
- Vocal-cord Radiotherapy, Complete Larynx Radiotherapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 155 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Head and Neck Cancer
Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
RATIONALE: Endoscopic surgery is a less invasive type of surgery for laryngeal cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00334997
- Testing
- endoscopic surgery, laser surgery, radiation therapy
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College London Hospitals
Benign Neoplasm of Vocal Fold - Glottis
Intranasal Dexmedetomidine Premedication
Most patients with preoperative varying degrees of stress, anxiety, which makes the stress response in patients and affect the normal conduct of anesthesia and surgery.The sympathetic system hyperexcitability prone to cause…
- Trial name
- NCT02108171
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 81 people
- Sponsor
- Guangzhou First People's Hospital
Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma
Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma
Objectives: Transoral Laser Microsurgery (TLM) is widely used in for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is a safe and commonly-used injectable in vocal cord augmentation.
- Conditions
- Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma, Voice Disorders, Laryngeal Cancer
- Trial name
- NCT04525066
- Testing
- Hyaluronic acid, No Hyaluronic Acid Injection Injection
- Volunteers
- 39 people
- Sponsor
- Ayhman Al Afif
Early Glottic Cancer
Hypofractionated Radiotherapy With 3.5 Gy Per Fraction for Early Glottic Cancer
Early-stage glottic carcinoma (T1-T2N0M0) is typically managed with either transoral laser microsurgery or definitive radiotherapy, both providing excellent local control rates and voice preservation outcomes.
- Trial name
- NCT07197060
- Volunteers
- 70 people
- Sponsor
- Assiut University