Clinical trials: Early Cancer Detection
Colorectal Carcinoma
Health Service Intervention for the Improvement of Access and Adherence to Colorectal Cancer Screening
This phase I study investigates how well a health service program called Witness CARES Services works in increasing access and adherence to colorectal cancer screening in patients who have not undergone a colorectal screening in…
- Trial name
- NCT04607291
- Testing
- Community Health Service, Survey Administration
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cervical Cancer, Human Papillomavirus Infection
Prospective Evaluation of Self-Testing to Increase Screening
Regularly attending for Pap test cervical cancer screening in a clinic is often unfeasible and/or unacceptable to many women. This study evaluates if mailing and testing self-sampled kits for high-risk human papillomavirus (HPV)…
- Trial name
- PRESTIS (NCT03898167)
- Testing
- Telephone Recall, Mailed HPV Self-Sampling Kit, Patient Navigation
- Where
- United States
- Volunteers
- 2,474 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Early Detection of Cancer, Lung Neoplasms
Evaluation of a Scalable Decision Support and Shared Decision Making Tool for Lung Cancer Screening
The purpose of this project is to increase appropriate low-dose computed tomography (LDCT) lung cancer screening through the development and wide dissemination of patient-centered clinical decision support (CDS) tools that (1)…
- Trial name
- NCT04498052
- Testing
- EHR-integrated Shared Decision Making Tool and Clinical Decision Support for Lung Cancer Screening
- Where
- United States
- Volunteers
- 1,855 people
- Sponsor
- University of Utah
Sickle Cell Trait
Increasing Documentation and Disclosure of Sickle Cell Trait Status: An Implementation Science Approach
The hemoglobinopathy newborn screen (NBS) performed on all neonates in the U.S. allows for early life-saving medical care for infants with sickle cell disease (SCD), an autosomal recessive genetic disorder.
- Trial name
- NCT05387564
- Testing
- SCT Documentation and Disclosure Toolkit (SCT-DD)
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Nemours Children's Clinic
Electronic Cigarette Use, Smoking, Cigarette
Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening
This study investigates the feasibility, acceptability, and short-term effects of providing 4 weeks of complimentary electronic cigarettes (ECs) to 30 individuals who did not quit after smoking cessation treatment provided in the…
- Conditions
- Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT06472869
- Testing
- NJOY ACE e-cigarette
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Tobacco Use
Lung Cancer Screening Navigation for Homeless People
The investigators will conduct a pragmatic clinical trial to test the effect of patient navigation on lung cancer screening (LCS) low-dose computed tomography (LDCT) completion among Boston Health Care for the Homeless Program…
- Conditions
- Lung Cancer, Tobacco Use, Homelessness
- Trial name
- NCT04308226
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, Colorectal Polyps
The Colorectal Breath Analysis (COBRA) Study
This study aims to determine whether a breath test could be used for early detection of colorectal cancer and colorectal polyps.
- Conditions
- Colorectal Cancer, Colorectal Polyps, Colorectal Adenocarcinoma
- Trial name
- COBRA (NCT03699163)
- Testing
- Breath sample
- Where
- 8 sites in United Kingdom
- Volunteers
- 1,855 people
- Sponsor
- Imperial College London
Cervical Cancer, Papillomavirus Infection
HPV Self-Sampling in Somali Women (Isbaar Project)
This study plans to assess the effect of implementing HPV self-sampling in primary care on uptake of cervical cancer screening in 30-65 year old Somali women who are due for cervical cancer screening.
- Conditions
- Cervical Cancer, Papillomavirus Infection, Uterine Diseases, Uterine Cervical Disease
- Trial name
- Isbaar (NCT05453006)
- Testing
- COPAN 552c.80 FLOQSwab
- Where
- United States
- Volunteers
- 3,367 people
- Sponsor
- University of Minnesota
Colon Cancer
Engaging Patients in Colon Cancer Screening Decisions During COVID-19
The goal of the study is to examine whether a shared decision making intervention improves decision making about colon cancer screening for patients who had their colonoscopy delayed or postponed due to the COVID pandemic.
- Trial name
- NCT04548531
- Testing
- Shared Decision Making
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, Schizophrenia
Effectiveness of the Screen, Test, Immunize, Reduce Risk, and Refer (STIRR) Intervention for People With Both a Mental and Substance Abuse Disorder
This study will determine the effectiveness of the STIRR (Screen, Test, Immunize, Reduce risk, and Refer) intervention in increasing rates of testing, immunization, referral, and treatment for blood-borne diseases, such as…
- Conditions
- HIV Infections, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00316303
- Testing
- Twinrix, Enhanced treatment as usual
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Lung Cancer
Tele-Navigation of Lung Cancer Screening (Tele-Navi LCS)
Adherence to annual follow up is critical to achieving mortality benefits and optimizing cost-effectiveness of lung cancer screening (LCS). However, adherence to LCS follow-up in the real world is suboptimal.
- Trial name
- NCT05021133
- Testing
- Tele-Navi LCS
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Massachusetts, Worcester
Elderly Cancer Patients, Cognitive Impairment
Validation of the Freund Clock Drawing Test to Screen for Cognitive Dysfunction in Cancer Patients
A Comprehensive Geriatric Assessment (CGA) has become a fundamental aid in the evaluation and treatment planning of older cancer patients.
- Trial name
- PROACTIVE (NCT01749995)
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- General Hospital Groeninge
Human Papilloma Virus
Patient Self-sampling of HPV to Screen for Cervical Cancer
The purpose of this study is to validate a patient self-sampling vaginal collection kit and laboratory testing for the detection of HPV (human papillomavirus) infection.
- Trial name
- NCT05600283
- Testing
- Swab kit (COBAS HPV 4800 Assay -Evalyn brush), Clinician-collection of cervical sample for HPV testing
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Mayo Clinic
Breast Cancer Screening, Oncology
Project Insight: Feasibility of a Breast Cancer Screening Decision Support Tool
The purpose of this investigation is to conduct a feasibility study to evaluate the potential for implementing the developed decision support tool with Latina, Black, and non-Latina White women.
- Conditions
- Breast Cancer Screening, Oncology, Preventative Medicine, Mammography
- Trial name
- NCT04741503
- Testing
- Breast Cancer Screening Decision Support Tool, National Cancer Institute Breast Cancer Screening PDQ
- Where
- United States
- Volunteers
- 1,277 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer
Intervention to Promote Breast Cancer Screening Among American Indian Women
Our objectives in this project are to develop and evaluate the feasibility and effectiveness of the Mobile Web App Breast Cancer Screening (wMammogram) intervention that is culturally tailored for AI women residing in rural…
- Trial name
- NCT05530603
- Testing
- Educational mobile app
- Where
- 2 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of South Dakota
Lung Cancer, Smoking Cessation
PCORI-CER-1306-03385 Informed Decisions About Lung Cancer Screening
Educational research study where goal is to test educational materials that help people make informed decisions about lung cancer screening.
- Conditions
- Lung Cancer, Smoking Cessation, Tobacco Use Cessation
- Trial name
- NCT02286713
- Testing
- Patient Decision Aid, Standard Educational Information, Follow-Up Assessments: Questionnaires
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Gastroesophageal Varices
Dual Energy CT as a Noninvasive Method to Screen for Gastroesophageal Varices
Cirrhosis leads to portal hypertension and development of gastroesophageal varices, which are the most common cause for bleeding in cirrhosis and a major cause of death.
- Trial name
- NCT03910413
- Testing
- Duel Energy CT
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham