Clinical trials: Early Cancer Detection
Colorectal Cancer
Evidence Based Colorectal Cancer Screening for the Uninsured - Sub-study
This is a sub-study nested within a previously initiated clinical study (# NCT01946282) focusing on individuals not previously randomized at baseline to the original interventions.
- Trial name
- NCT02651974
- Testing
- Control condition, Cost condition, Cost/Future condition
- Volunteers
- 8,565 people
- Sponsor
- University of Texas Southwestern Medical Center
Gastric Cancer, H Pylori Infection
H. Pylori Screen-and-treat Study in a Population of Young Adults
Gastric cancer remains a major challenge to public health on a global scale. H. pylori related cancer burden contributes to the largest proportion of cancer cases attributable to infections in Europe.
- Conditions
- Gastric Cancer, H Pylori Infection, H Pylori Eradication, H-pylori
- Trial name
- NCT06275204
- Testing
- Bismuth-based quadruple therapy, Levofloxacin-based quadruple therapy, Standard triple therapy
- Where
- 7 sites in Croatia, Ireland and 4 more
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Breast Cancer Detection, Early Detection of Cancer
AI-Based Self-Supervised Learning Model Using Non-Contrast Breast MRI for Early Screening and Clinical Utility Evaluation
Breast cancer is the most common malignant disease among women worldwide, with rising incidence and younger age at onset in China.
- Conditions
- Breast Cancer Detection, Early Detection of Cancer, AI (Artificial Intelligence)
- Trial name
- B-MRI-AI (NCT07205276)
- Testing
- Non-contrast multiparametric breast MRI with AI-based radiomics analysis, Standard radiologist reading of non-contrast multiparametric breast MRI
- Volunteers
- 30,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Urothelial Carcinoma, Lynch Syndrome
Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study)
Lynch syndrome (LS) is an inherited cancer predisposition syndrome caused by pathogenic germline variants in DNA mismatch repair (MMR) genes.
- Trial name
- NCT06218433
- Testing
- Urothelial cancer screening using urine tumor DNA test, Urothelial cancer screening using urine cytology (comparator)
- Where
- 2 sites in Canada, Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Breast Cancer
Artificial Intelligence in Mammography Screening in Norway
The purpose of this randomized controlled trial is to compare the number of breast cancers detected among women who had their screening mammograms interpreted by artificial intelligence (AI) in combination with one or two breast…
- Trial name
- AIMS Norway (NCT06032390)
- Testing
- AI assisted mammography screening interpretation, Standard mammography screening interpretation
- Where
- Norway
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Cervical Cancer, Cervical Dysplasia
Acceptability and Efficacy of Self-sampling for Cervical Cancer Screening: A Pilot Study
In Singapore, the current cervical cancer screening uptake among women in Singapore has remained at low 50% since its introduction in 2004.
- Conditions
- Cervical Cancer, Cervical Dysplasia, Human Papillomavirus Infection
- Trial name
- NCT03813576
- Testing
- Self-collected HPV vaginal swab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy With Modified Injection Technique
Internal Mammary Lymph Node (IMLN) and Axillary Lymph Node (ALN) are regarded as "the first station" of lymphatic drainage in breast cancer, serving as an important reference for lymph staging and decision-making.
- Trial name
- NCT03541278
- Testing
- MIT, IM-SLNB
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shandong Cancer Hospital and Institute
Precancerous Condition
Optical Coherence Tomography in Tissue Samples From Women Undergoing Mastectomy for the Treatment or Prevention of Breast Ductal Intraepithelial Neoplasia
RATIONALE: New diagnostic procedures, such as optical coherence tomography, may be effective in finding tumor cells. PURPOSE: This clinical trial is studying optical coherence tomography in tissue samples from women undergoing…
- Trial name
- NCT00807404
- Testing
- histopathologic examination, optical coherence tomography
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate With Endocuff-Assisted Colonoscopy - an Italian Trial
In European countries, colorectal cancer (CRC) represents an important public health problem. It is widely held view that most carcinomas develop from an adenoma-carcinoma progression.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp, Colorectal Neoplasms
- Trial name
- ITAvision (NCT03612674)
- Testing
- Standard colonoscopy, ARC Endocuff Vision
- Where
- 12 sites in Italy
- Volunteers
- 2,100 people
- Sponsor
- Cancer Prevention and Research Institute, Italy
Stroke, Dysphagia
Evaluation of Oral Screen Training With IQoro as Treatment for Dysphagia After Stroke
Purpose The purpose of the study is to evaluate if training with oral screen IQoro® improves swallowing in patients with dysphagia after stroke.
- Trial name
- NCT04868955
- Testing
- Oral screen training
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Rebecca Norrman and Elin Rova
HPV
Self-sampling for Human Papillomavirus (HPV) Among Patients Receiving Colposcopy
This study seeks to compare the accuracy and acceptability of HPV testing self-sampling kit and standard clinician-sampling for HPV testing.
- Trial name
- NCT04585243
- Testing
- Evalyn Brush
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Milton S. Hershey Medical Center
Cervical Cancer Screening, Gynecologic Cancers
Compliance to Cervical Cancer Chemoradiation Guidelines: A Multicentric Implementation Audit and Resource Assessment Initiative of National Cancer Grid of India
This is a combination of retrospective and prospective observational study that will be performed across NCG and other participating centers to report compliance to chemoradiation for cervical cancer.
- Conditions
- Cervical Cancer Screening, Gynecologic Cancers, Treatment Compliance, Chemoradiotherapy
- Trial name
- NCG-Compliance (NCT07290972)
- Testing
- Not applicable- observational study
- Where
- 2 sites in India
- Volunteers
- 618 people
- Sponsor
- Tata Memorial Hospital
Human Papilloma Virus Related Cervical Carcinoma
The Women's Screening and Self-Testing Program (PROMETA) Study
This proposal directly addresses the ability to safely scale-up a Screen-Triage-Treat approach to cervical cancer screening. The investigators propose to capitalize on a pool of screen-eligible women accessing routine care within…
- Trial name
- PROMETA (NCT06810739)
- Testing
- HPV DNA testing be self-collected vaginal swab
- Where
- Mozambique
- Volunteers
- 8,445 people
- Sponsor
- Tulane University
Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
This study will test a remote approach to help people who may be at higher risk for pancreatic cancer learn about and decide whether to get genetic testing and a blood test that looks for signs of several cancers (MCED testing).
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer, Genetic Testing, Multi-cancer Early Detection
- Trial name
- REGENERATE (NCT07787156)
- Testing
- Telephone education session, Online educational materials
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Pleural Mesothelioma, Asbestos Exposure
Mesothelioma Early Detection by VOCs
This is a two phase study, The first phase (phase 1) will identify potential biomarkers among asbestos exposed individuals with pleural mesothelioma.
- Conditions
- Pleural Mesothelioma, Asbestos Exposure, Pleural Plaque
- Trial name
- MED-VOC (NCT04106973)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Henry Ford Health System
Breast Neoplasms
Artificial Intelligence Integration in Breast Cancer Screening: The ANIHTA Study
The goal of this observational study is to evaluate how artificial intelligence (AI) can be integrated into an organized breast cancer screening program for women aged 50-74 years undergoing mammography screening.
- Trial name
- ANIHTA (NCT07879937)
- Testing
- Artificial intelligence-based software for mammography, Discrete Choice Experiment on AI-Supported Breast Cancer Screening
- Where
- Italy
- Volunteers
- 200,075 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer Screening
Left Lateral Position Versus Supine Position in Colonoscopy
Currently, colonoscopy is a minimally invasive method that can be used as a diagnostic and therapeutic method by endoscopists, gastroenterologists and coloproctologists.
- Trial name
- NCT06664762
- Testing
- Left lateral position intervention, Supine position intervention
- Where
- 3 sites in Mexico
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Breast Cancer
Improving Access to Breast Cancer Screening and Treatment in Nigeria: The Triple Mobile Assessment and Patient Navigation Model
The goal of this study is to establish a novel community-based breast cancer program to address delayed presentation and lack of access to diagnostic and treatment facilities in South-West Nigeria.
- Trial name
- NCT05321823
- Testing
- iBreast device, Clinical Breast Examination, Breast ultrasound
- Where
- Nigeria
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University
Colon Polyp, Adenoma Colon
AmplifEYE Colonoscopy vs Standard Colonoscopy
Colonoscopy screening is proven to reduce mortality rates for colorectal cancer, which relies on early detection and removal of colonic polyps.
- Conditions
- Colon Polyp, Adenoma Colon, Serrated Polyp, Colonic Neoplasms
- Trial name
- NCT03814369
- Testing
- AmplifEYE
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
HIV Infection, Human Papillomavirus-Related Cervical Carcinoma
Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial
Background In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical cancer (CC).
- Conditions
- HIV Infection, Human Papillomavirus-Related Cervical Carcinoma, Screening Strategy
- Trial name
- NCT06708351
- Testing
- Best Practice, Health Promotion and Education, HPV Self-Collection
- Where
- Kenya
- Volunteers
- 2,280 people, healthy volunteers welcome
- Sponsor
- Emory University
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