Clinical trials: Early Acute Respiratory Failure
Acute Respiratory Failure
Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU…
- Trial name
- NCT01707303
- Testing
- Early ICU rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Respiratory Tract Infections, Pneumonia, Bacterial
Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart Failure
Introduction: Acute Heart Failure is frequently decompensated by pulmonary infection, but the diagnosis of pulmonary infection sometimes is difficult in these patients due to similar signals and clinical symptoms in both…
- Conditions
- Respiratory Tract Infections, Pneumonia, Bacterial, Heart Failure
- Trial name
- EPICAD (NCT02787603)
- Testing
- Interruption of antibiotic treatment due to PCT measurement
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Failure
The Value of Rapid Shallow Breathing Indeks in Predicting Non-invasive Mechanical
There are some criteria such as the most frequently used parameters to predict the failure of non-invasive mechanical ventilation, the APACHE 2 score, the presence of pneumonia and ARDS in the etiology, and no improvement in one…
- Trial name
- RSBI (NCT04780503)
- Testing
- Rapid Shallow Breathing Index
- Where
- Turkey (Türkiye)
- Volunteers
- 267 people
- Sponsor
- Izmir Katip Celebi University
Non Invasive Ventilation, Acute Respiratory Failure
Prevalence of an Early Success of Non-invasive Ventilation in the Emergency Departement.
Non-invasive ventilation is a mechanical ventilation who provides ventilatory support through a facemask, and without the need for tracheal intubation.
- Trial name
- VENTIRU (NCT06213623)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Poitiers University Hospital
Guillain Barré Syndrome, Acute Respiratory Failure
Early Mechanical Ventilation for Guillain Barré Syndrome
The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
- Trial name
- NCT00167622
- Testing
- mechanical ventilation, physiotherapy and oxygen if needed
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University of Versailles
Patients With Acute Hypoxemic Respiratory Failure
Wean Early With HFNCO vs NPPV in Patients With AHRF
The main purpose of the present study is to verify whether, as compared with conventional weaning, early weaning with high-flow nasal cannula oxygenation or noninvasive positive pressure ventilation may more effective in…
- Trial name
- NCT03171935
- Testing
- High-Flow Nasal Cannula Oxygenation, Noninvasive Positive Pressure Ventilation, Conventional weaning
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Beijing Chao Yang Hospital
COVID-19, Acute Hypoxemic Respiratory Failure
Early Versus Delayed Intubation of Patients With COVID-19
Although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (COVID-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains…
- Trial name
- EUDOCO (NCT04632043)
- Testing
- Endotracheal intubation
- Where
- Greece
- Volunteers
- 2 people
- Sponsor
- Evangelismos Hospital
Acute Lung Injury, ALI
A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure
The aim of this study will test the safety, tolerability, and efficacy of RLS-0071 for approximately 28 days in comparison to a placebo control in patients with acute lung injury due to COVID-19 pneumonia in early respiratory…
- Conditions
- Acute Lung Injury, ALI, COVID-19
- Trial name
- NCT04574869
- Testing
- RLS-0071 10 mg/kg, RLS-0071 40 mg/kg
- Where
- United States
- Sponsor
- ReAlta Life Sciences, Inc.
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
COVID-19
Early Versus Late Use of Hi-VNI in Covid-19
This study evaluate early administration of high-velocity nasal insufflation in COVID-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of Non…
- Trial name
- NCT05663138
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Early Mobility, Critically Ill
Early Mobilization in Ventilated SEpsis & Acute Respiratory Failure Study
Early mobilization in Ventilated sEpsis \& acute Respiratory failure Study: EVER Study
- Trial name
- EVER (NCT04582760)
- Testing
- early mobilization
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Critical Illness, Acute Respiratory Failure
Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial
This is a stepped-wedge, cluster randomized, trial evaluating the effect of an early goal-directed mobilization intervention for ICU patients with acute respiratory failure within 12 medical and surgical ICUs across 4 hospitals…
- Trial name
- STAND (NCT03863470)
- Testing
- Early mobilization intervention
- Where
- 4 sites in United States
- Volunteers
- 1,917 people
- Sponsor
- University of Pennsylvania
Acute Hypoxemic Respiratory Failure
Noninvasive Positive Pressure Ventilation for Early Extubation of Acute Hypoxemic Respiratory Failure
Acute hypoxaemic respiratory failure (AHRF) refers to pathological states in which arterial blood oxygenation is severely impaired，and which need invasive positive pressure ventilation (IPPV) as respiratory support technique in…
- Trial name
- NPPV (NCT01151501)
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Sponsor
- Beijing Chao Yang Hospital
Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours
Early Chair Sitting Exercise in Mechanically Ventilated Critically Ill Patients
The occurrence of an acute respiratory failure necessitates mostly admission to ICU and mechanical ventilation (MV). Rapid and safe discontinuation of MV should be the objective for the majority of patients.
- Trial name
- RehabVent (NCT02021227)
- Testing
- Early chair sitting exercise
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Acute Decompensated Heart Failure, COPD Exacerbation
Use of ΔIVC for Early Diagnosis of AHF in AECOPD
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05327374
- Testing
- calculation of the inferior vena cava collapsibility index
- Where
- 3 sites in Tunisia
- Volunteers
- 401 people
- Sponsor
- University of Monastir
Patients at Risk of Acute Respiratory Failure
Early Detection of Acute Respiratory Failure Using an Intelligent Respiratory Monitoring System
Introduction: The monitoring of respiratory patterns is crucial in the management of respiratory diseases, but in many cases, it still relies on subjective and visual assessment.
- Trial name
- NCT07164586
- Testing
- Respiratory Pattern Monitoring, Diaphragmatic Excursion, Respiratory muscle electrical activity
- Where
- 3 sites in Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Mechanical Ventilation, Corona Virus Infection
Early Extubation for Patients With Acute Hypoxemic Respiratory Failure
The objective of the study is to evaluate the efficacy of helmet NIV in reducing the duration of invasive mechanical ventilation in order to minimize ventilator needs during the COVID-19 pandemic.
- Trial name
- NCT04349332
- Testing
- Helmet non-invasive ventilation (NIV)
- Where
- United States
- Sponsor
- University of Chicago
Bronchiolitis, Respiratory Syncytial Virus (RSV)
High Flow Nasal Cannula Therapy in Bronchiolitis : Early vs Rescue
The enrolled RSV-bronchiolitis patients will be randomized into two arms , the early HHHFNC group and the standard therapy group with rescue HHHFNC to study the efficacy of this treatment.
- Trial name
- NCT03095495
- Testing
- Heated Humidified High Flow Nasal Cannula, Standard Therapy (Low Flow Nasal Cannula)
- Where
- Qatar
- Volunteers
- 28 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Failure, ECMO
Cardinality Matching Study of Early v.s. Delayed VV ECMO in Severe Respiratory Failure
Clinical reasoning and recent data suggest that early use of venovenous extracorporeal membrane oxygenation in refractory respiratory failure may confer a survival advantage.
- Trial name
- NCT03981393
- Volunteers
- 667 people
- Sponsor
- University of Cambridge
Chronic Obstructive Pulmonary Disease
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of morbidity and mortality for patients and cost to the society.
- Trial name
- MORPHEUS I/IIa (NCT04427826)
- Testing
- Morphine hydrochloride
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Grenoble