Clinical trials: ECT, active
Major Depressive Disorder, Treatment Resistant Depression
Ketamine Augmentation of ECT in Treatment-Resistant Depression
This is a randomized, double-blind, placebo-controlled phase 3 clinical trial evaluating the additive effect of intravenous ketamine in combination with electroconvulsive therapy (ECT) in patients with treatment-resistant major…
- Trial name
- Ketamina (NCT07088380)
- Testing
- Ketamine Hydrochloride
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Vita-Salute San Raffaele
Major Depressive Episode, ECT
Metabolomics During ElectroConvulsivoTherapy
Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode.
- Trial name
- METECT (NCT05973643)
- Testing
- Electroconvulsive therapy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hôpital le Vinatier
Electroconvulsive Therapy, Knowledge, Attitudes, Practice
Development of Virtual Reality for Nursing Students: Electroconvulsive Therapy
Project: "Development of virtual reality for nursing students: ECT" For this project the researchers will adapte 'health belief model' as a core concept for developing knowledge, attitude and skills of nursing students to take…
- Trial name
- Experimental (NCT06980831)
- Testing
- ECT group
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University
Major Depressive Disorder (MDD)
Accelerated TMS for Treatment-Resistant ECT
This study investigates whether an additional treatment using transcranial magnetic stimulation (TMS) can help severely depressed patients who did not respond well to electroconvulsive therapy (ECT).
- Trial name
- A-TREC (NCT07115628)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Music Intervention, Electroconvulsive Therapy Treated Patients
The Effect of a Music Intervention on Postictal Agitation in Electroconvulsive Therapy Patients
This study will investigate the effect of music on postictal agitation when played peri-interventionally for patients undergoing electroconvulsive therapy for severe depression.
- Conditions
- Music Intervention, Electroconvulsive Therapy Treated Patients, Agitation on Recovery From Sedation
- Trial name
- MUSE (NCT06817330)
- Testing
- Intervention group, listening to recorded music, Control group, headphones with no music
- Where
- 2 sites in Netherlands
- Volunteers
- 92 people
- Sponsor
- Erasmus Medical Center
Major Depressive Disorder (MDD)
Effectiveness of MST Versus ECT for Major Depressive Episode
Despite advancements in Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) for Major Depressive Disorder (MDD), there remains a need for further research to replicate clinical outcomes and understand the…
- Trial name
- NCT06409325
- Testing
- MST, ECT
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Mental Health Center
Major Depression, Bipolar Affective Disorder
Treatment Response In ECT Patients
Clarification Regarding Study Type: Observational This study is a prospective, non-interventional observational study. The decision to administer Electroconvulsive Therapy (ECT) and the selection of the anesthetic agent (ketamine…
- Conditions
- Major Depression, Bipolar Affective Disorder, Bipolar Depression Depressed Phase
- Trial name
- NCT07463911
- Testing
- Electroconvulsive Therapy (ECT)
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Nurdan Sağbaş
ECT-related Anxiety
VR-relaxation for ECT-related Anxiety
The goal of this clinical trial is to learn if there is an effect of Virtual Reality (VR) based-relaxation on electroconvulsive therapy (ECT)-related anxiety.
- Trial name
- NCT07546526
- Testing
- VR-based relaxation, Breathing exercises, Treatment as usual
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitair Ziekenhuis Brussel
Depressive Disorder, Major, Depression, Bipolar
Optimal Electrical Stimulus During Electroconvulsive Therapy
Synopsis Aim: The purpose of the study is to determine the stimulus of electrical current during electroconvulsive therapy (ECT) that produces the optimal balance between antidepressant effect and memory disturbance.
- Trial name
- NCT04057378
- Testing
- Electroconvulsive therapy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Region Örebro County
ECT, Treatment Resistant Depression
CET- REM (Correlating ECT Response to EEG Markers)
Single-center study to determine the relationship between changes in depression symptoms and electroencephalographic (EEG) patterns induced by electroconvulsive therapy (ECT)
- Trial name
- NCT04451135
- Testing
- Electroencephalographic (EEG), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Ictal Electroencephalographic (EEG) Measurements
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Electroconvulsive Therapy, Depression
Blood Biomarkers in Electroconvulsive Therapy
The present multi-disciplinary study will assess blood biomarkers to investigate putative mechanisms of action of ECT. Laboratory findings will be correlated to clinical parameters, cognitive measures and psychometric outcome…
- Conditions
- Electroconvulsive Therapy, Depression, Blood Biomarkers
- Trial name
- NCT05515159
- Testing
- electroconvulsive therapy
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Haukeland University Hospital
Major Depressive Disorder, Bipolar Disorder
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
This prospective, open-label clinical trial aims to compare a novel "Venous Tourniquet with Regional Low-Dose Sugammadex" method against the gold standard "Arterial Tourniquet" (Isolated Forearm Technique - IFT) for monitoring…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT07534475
- Testing
- Device: Arterial Tourniquet, Device: Venous Tourniquet, Sugammadex
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Medipol University
Treatment Resistant Schizophrenia, Schizophrenia
Magnetic Seizure Therapy for Schizophrenia - Trial
This trial aims to assess the clinical effects and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Treatment Resistant Schizophrenia (RS).
- Conditions
- Treatment Resistant Schizophrenia, Schizophrenia, Schizoaffective Disorder
- Trial name
- MAST (NCT06672588)
- Testing
- Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT)
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Centre for Addiction and Mental Health
Hemodynamic Response
Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is a treatment modality that induces therapeutic seizures through electrical stimulation for the management of certain psychiatric disorders.
- Trial name
- NCT07824817
- Testing
- Saline (0.9% NaCl), Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Inonu University
Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA)
ECCA's Turkish Validity and Reliability Study and Comparison With Other Cognitive Assessment Tests
Electroconvulsive therapy (ECT) is one of the oldest biological treatment methods used in psychiatry, based on inducing widespread seizures in the brain with externally applied controlled electrical currents.
- Conditions
- Electroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA), Montreal Cognitive Assessment (MoCA), Turkish Adaptation
- Trial name
- NCT07527234
- Testing
- ElectroConvulsive Therapy Cognitive Assessment (ECCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Pamukkale University
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Education, Medical, Undergraduate, Electroconvulsive Therapy
Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therapy Training: A Non-Inferiority Study
The goal of this prospective, open-label non-inferiority randomized controlled trial is to investigate if Virtual Reality (VR) based simulation are an effective training tool for novice medical trainees.
- Conditions
- Education, Medical, Undergraduate, Electroconvulsive Therapy, Virtual Reality Simulation
- Trial name
- ECT-SIM (NCT07350278)
- Testing
- Virtual Reality electroconvulsive therapy simulator, Mannequin Simulator
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Paget Disease of the Vulva, Vulva Cancer
ECT STUDY High-grade or Initially Invasive Vulva - GinOnc-ECT Study
Patients with a new diagnosis or recurrence of high-grade squamous precancerous lesions or initially non-invasive vulvar Paget's disease, who have not undergone other types of treatment, will be considered at the Fondazione…
- Trial name
- NCT06715592
- Testing
- Bleomicina
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fibromyalgia (FM)
Electroconvulsive Therapy for Refractory Fibromyalgia
This multicenter, prospective, randomized, open-label, wait-list controlled trial will evaluate the efficacy and safety of bilateral electroconvulsive therapy (ECT) for adults with refractory fibromyalgia (FM).
- Trial name
- NCT07835516
- Testing
- Electroconvulsive Therapy, Standard medical treatment
- Volunteers
- 58 people
- Sponsor
- Beijing Tiantan Hospital