Clinical trials: ECMO Treatment
Extracorporeal Membrane Oxygenation Complication
Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation
The purpose of this study was to evaluate the efficacy and safety of bivalirudin in anticoagulation therapy in patients with extracorporeal membrane oxygenation (ECMO) compared with unfractionated heparin.
- Trial name
- NCT06275555
- Testing
- bivalirudin, unfractionated heparin
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Xiaotong Hou
Extracorporeal Membrane Oxygenation, Cardio/Pulm: Heart Failure
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort I: Veno-arterial Extracorporeal Membrane Oxygenation (PLUTO-I)
Invasive pressure-volume (PV) loop measurements have the potential to confirm or refute earlier computer simulations and animal studies regarding changes in cardiovascular physiology induced by (veno-arterial) ECMO.
- Trial name
- PLUTO-I (NCT05909280)
- Testing
- Pressure-volume loop measurements
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Cardiac Arrest, Extracorporeal Membrane Oxygenation
Hydrogen's Feasibility and Safety as a Therapy in ECPR
The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e.
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
- Trial name
- HydrogenFAST (NCT05574296)
- Testing
- Hydrogen, Usual care
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation Complication
Application of Early Physical Therapy Regimens in Patients With Veno-venos Extracorporeal Membrane Oxygenation
Promote early recovery through the application of early physiotherapy programs for VV-ECMO patients
- Trial name
- VV-ECMO (NCT04918498)
- Testing
- early physiotherapy programs, routine treatment
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
ARDS, Human, Extracorporeal Membrane Oxygenation
Use of Prone Position Ventilation in Danish Patients With COVID-19 Induced Severe ARDS Treated With VV-ECMO
Prone position ventilation was used 220 times in 44 out of 68 patients with severe COVID-19 induced ARDS treated with VV-ECMO. PPV treated patients did not benefit from PPV and the incidence of PPV related adverse events was high
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation, COVID-19 Acute Respiratory Distress Syndrome, Prone Position
- Trial name
- NCT05693051
- Testing
- Prone position ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 68 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO
The SURVIVE trial aims to test whether using an anti-thrombotic regimen involving cangrelor can reduce bleeding risk while maintaining effective antithrombotic effects in patients on VA-ECMO due to cardiogenic shock (CS)/ cardiac…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Platelet Dysfunction
- Trial name
- SURVIVE (NCT06792643)
- Testing
- Cangrelor
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Cardiac Arrest, Cardiopulmonary Resuscitation
Evaluation of eCPR Survivors
A cardiac arrest event has severe impact on the patient´s health-related quality of life. Survival of cardiac arrest does not innately translate to favorable quality of life.
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Extracorporeal Membrane Oxygenation Complication, Myocardial Infarction
- Trial name
- NCT05339854
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
ICU Patients With ECMO And-or RRT and With Gram Negative Infections Susceptible to BL-BLIs
Extracorporeal Therapy and Therapeutic Drug Monitoring
The aim of this study is to comparatively evaluate serum concentrations of continuously applied antibiotics in ICU patients, with and without ECMO/RRT support.
- Trial name
- NCT07287813
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cardiac Arrest
Refractory Out-Of-Hospital Cardiac Arrest Treated With Mechanical CPR, Hypothermia, ECMO and Early Reperfusion
Sudden out-of-hospital cardiac arrest (OHCA) is a leading cause of death in Australia. The most common cause of OHCA is a heart attack.
- Trial name
- CHEER (NCT01186614)
- Testing
- Automated CPR, ECMO, Coronary angiography
- Where
- 2 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Bayside Health
Cardiac Arrest, Myocardial Infarction
Monitoring Antiplatelet Drugs in Cardiac Arrest Patients
Dual Antiplatelet Therapy (DAPT) with acetylsalicylic acid (ASA) and oral P2Y12 inhibitor (Clopidogrel, Ticagrelor or Prasugrel) is recommended in STEMI or NSTEMI patients undergoing primary Percutaneous Coronary Intervention…
- Conditions
- Cardiac Arrest, Myocardial Infarction, Extracorporeal Membrane Oxygenation, Platelet Dysfunction
- Trial name
- PLT-ECMO (NCT05730114)
- Testing
- Antiplatelet Drug
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milano Bicocca
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Critical Illness, Extracorporeal Membrane Oxygenation Complication
Does Extra-Corporeal Membrane Oxygenation Alter Antiinfectives Therapy Pharmacokinetics in Critically Ill Patients
Observational study Primary Objective: To study whether ECMO alters the PK of anti-infectives including voriconazole, posaconazole and caspofungin in critically ill patients on ECMO Secondary Objectives: Develop Population PK…
- Conditions
- Critical Illness, Extracorporeal Membrane Oxygenation Complication, Infection
- Trial name
- EAT-PK (NCT04674657)
- Testing
- blood drug concentration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Long Term Adverse Effects, Pneumonia
Long-term Follow Up of Adult Patients Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure
Follow-up after treatment with Extracorporeal Membrane Oxygenation (ECMO) at the ECMO Center Karolinska. Patients: adult survivors treated with ECMO for severe refractory respiratory failure at least 5 years earlier.
- Conditions
- Long Term Adverse Effects, Pneumonia, Acute Respiratory Distress Syndrome, Sepsis
- Trial name
- NCT03031275
- Testing
- High-resolution computed tomography, Magnetic resonance imaging, Cognitive testing
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Support
Early LA Venting During Venoaterial ECMO Support
The EVOLVE-ECMO(Early Left Atrial Venting Versus Conventional Treatment For Left VEntricular Decompression During Venoarterial ExtraCorporeal Membrane Oxygenation Support) study is a randomized controlled trial to evaluate the…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Support, Refractory Pulmonary Edema
- Trial name
- NCT03740711
- Testing
- Left atrial venting
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Cardiac Arrest, Cardiopulmonary Arrest
ECMELLA vs. ECMO on 30-day Mortality
This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock
- Trial name
- NCT05175898
- Testing
- VA-ECMO, ECMELLA
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Antithrombinemia
Evaluation of the Relevance of Antithrombin Prescriptions at Strasbourg University Hospitals
Antithrombin (AT) is a physiological inhibitor of the coagulation cascade. In therapeutics, its presence in sufficient quantities is necessary for the pharmacological activity of unfractionated heparin (UFH) and partially…
- Trial name
- EPPATHUS (NCT07276074)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Strasbourg, France
Long Term Outcome
Long Term Follow up of Patients Who Were Treated With Extracorporeal Membrane Oxygenation for Pandemic Influenza A/H1N1 Induced Severe Respiratory Failure
Patients treated with Extracorporeal Membrane Oxygenation (ecmo) for severe respiratory or circulatory failure show severe long term disability due to impaired lung -, cerebral-, cognitive function and impaired quality of life.
- Trial name
- NCT01763060
- Testing
- CT scan, Cognitive function, MRI
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Karolinska University Hospital