Clinical trials: Dystonic Disorders
Dystonia, Cervical Dystonia
Novel Stimulation Patterns for the Treatment of Dystonia
Deep brain stimulation (DBS) is an effective surgical therapy for select Dystonia patients who are refractory to medications or who have generalized symptoms (e.g.
- Trial name
- NCT02468843
- Testing
- Biphasic DBS stimulation, Unified Dystonia Rating Scale, Burke-Fahn- Marsden scale
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Focal Dystonia
Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia
This study uses a computerized method of musical instrument digital interface (MIDI) quantification of performance before and after treatment with botulinum toxin type B (Myobloc ®, Solstice Neurosciences).
- Trial name
- NCT00208091
- Testing
- Botulinum toxin, type B
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Cervical Dystonia
Keppra for Cervical Dystonia
The purpose of this study is to evaluate if there is an improved response in CD symptoms when Keppra is used as adjunctive therapy to Botox.
- Trial name
- Keppra (NCT00760318)
- Testing
- Keppra
- Volunteers
- 17 people
- Sponsor
- University of South Florida
Focal Dystonia, Healthy Volunteers
Depotentiation in People With Focal Hand Dystonia
Background: Focal hand dystonia (FHD) causes muscles to contract, leading to abnormal movements or postures. Musicians, writers, and athletes often get it.
- Trial name
- NCT02106936
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand
The investigational drug being studied in this protocol is Incobotulinumtoxin A (Xeomin®). Botulinum toxin (BoNT) prevents the release of the acetylcholine from peripheral nerves, inhibiting muscle contractions.
- Trial name
- NCT02107261
- Testing
- incobotulinumtoxin A
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Meige Syndrome
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies.
- Trial name
- NCT06912282
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Torticollis, Dystonia
OnabotulinumtoxinA in the Management of Psychogenic Dystonia
The purpose of this research study is to evaluate if patients with psychogenic dystonia treated with onabotulinumtoxinA (BOTOX) injections will demonstrate lower severity and disability at one month and at three months than those…
- Trial name
- NCT02618889
- Testing
- CBT
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Cincinnati
Essential Tremor, Dystonia
The Effect of Alcohol on Common Tremor Syndromes
The aim of this interventional study is to compare the response to alcohol in patients with essential tremor (ET), essential tremor plus (ETplus), dystonic tremor (DT), tremor associated with dystonia (TaD) and tremor in…
- Conditions
- Essential Tremor, Dystonia, Parkinson Disease
- Trial name
- NCT06403280
- Testing
- Alcoholic drink
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Graz
Dystonia
Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia
Primary cranial-cervical dystonia is managed mainly by repeated botulinum toxin injections.This study is to establish whether subthalamic nucleus neurostimulation could improve symptoms in patients not adequately responding to…
- Trial name
- STN-CCD (NCT02583074)
- Testing
- Stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Torticollis
A Prospective, Observational Study of Patients With Cervical Dystonia (Dystonie) Treated With OnabotulinumtoxinA
This is an observational study to assess health-related quality of life in patients with cervical dystonia (dystonie) treated with OnabotulinumtoxinA per routine clinical practice.
- Trial name
- NCT01655862
- Testing
- OnabotulinumtoxinA
- Where
- 8 sites in Canada
- Volunteers
- 62 people
- Sponsor
- Allergan
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Laryngeal Dystonia
Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia
Laryngeal dystonia (LD) is a focal dystonia affecting laryngeal muscles, causing involuntary spasms that impair speech production.
- Trial name
- Neuro-VTS-LD (NCT07443891)
- Testing
- Vibrotactile Stimulation (VTS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cervical Dystonia, Primary
Computer Modelling of the Cervical Spine Movements in Cervical Dystonia
Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia.
- Trial name
- STICOB (NCT02894359)
- Testing
- cone beam imagery of cervical spine
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease, Essential Tremor
Cortical-Basal Ganglia Speech Networks
In this research study the researchers want to learn more about brain activity related to speech perception and production.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT04286308
- Testing
- electrophysiological data collection
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital