Clinical trials: Dystonic Disorders
Cervical Dystonia
Conversion to Dysport in CD
The first line of therapy for cervical dystonia patients is botulinum toxin injections, however injection parameter determination and optimization are challenging for physicians to do.
- Trial name
- NCT04270214
- Testing
- Dysport Injectable Product
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Western University, Canada
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Spasmodic Dysphonia, Voice Tremor
Sodium Oxybate in Spasmodic Dysphonia and Voice Tremor
Using a comprehensive approach of clinico-behavioral testing, neuroimaging and pharmacogenetics, the researchers will examine the clinical effects of sodium oxybate and the matched placebo on voice symptoms in spasmodic dysphonia…
- Trial name
- NCT03292458
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Kristina Simonyan
Spasmodic Dysphonia
Laryngeal Vibration for Spasmodic Dysphonia
The general aim of the research is to provide scientific evidence that vibro-tactile stimulation (VTS) represents a non-invasive form of neuromodulation that can induce measurable improvements in the speech of people with…
- Trial name
- SD-VTS (NCT03746509)
- Testing
- Laryngeal Vibration (Treatment), Laryngeal Vibration (Comparator)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rare Diseases
European Registry on Rare Neurological Diseases
The recent implementation of European Reference Networks for Rare Diseases (ERNs) is an unprecedented move to improve the care of patients suffering from rare health disorders by transnational collaboration.
- Trial name
- ERN-RND reg (NCT04319796)
- Testing
- Data set as defined by the ERN Research Workgroup of the European Commission
- Volunteers
- 5,000 people
- Sponsor
- University Hospital Tuebingen
X-Linked Dystonia Parkinsonism
MINGO Supplemental Trial in X-linked Dystonia-Parkinsonism Patients
To see whether MINGO, a food supplement, will be able to lessen the drastic weight loss seen among X-linked Dystonia Parkinsonism patients.
- Trial name
- MINGO (NCT03019458)
- Testing
- MINGO
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Sunshine Care Foundation
Laryngeal Dystonia, Spasmodic Dysphonia
Transcranial Magnetic Stimulation in Laryngeal Dystonia
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia.
- Trial name
- NCT07683767
- Testing
- Active rTMS, Speech-Language Therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Parkinson Disease, Dystonia
Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia
This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.
- Conditions
- Parkinson Disease, Dystonia, Autonomic Dysreflexia
- Trial name
- NCT03307161
- Testing
- osteopathic manual therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Dystonia
Pathophysiology of Focal Hand Dystonia
Background: Little is known about the problems in brain function in focal hand dystonia (FHD) or complex regional pain syndrome (CRPS) dystonia. It is unclear why some CRPS patients develop dystonia but others do not.
- Trial name
- NCT03223623
- Testing
- TMS, MRI, VASO Imaging
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Cervical Dystonia
Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia
The aim of this study is to assess longer term safety and effectiveness of Dysport®.
- Trial name
- NCT00288509
- Testing
- Botulinum toxin type A
- Where
- 18 sites in United States, Russia
- Volunteers
- 108 people
- Sponsor
- Ipsen
Cervical Dystonia
Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia
The purpose of this study is to evaluate how well a new drug called Dysport NG works and how safe it is, when it is used for the treatment of cervical dystonia. Dysport NG will be compared to an approved drug called Dysport.
- Trial name
- NCT01261611
- Testing
- Botulinum toxin type A
- Where
- 57 sites in Australia, Austria and 9 more
- Volunteers
- 382 people
- Sponsor
- Ipsen
Cervical Dystonia
Dystonia Treatment With Injections Supplemented By Transcranial Magnetic Stimulation
We applied 16 sessions of rTMS over 4 consecutive days for adult patients suffering from cervical dystonia who received botulinum toxin (BoNT) injections on a regular basis.
- Trial name
- D-TWIST (NCT04916444)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Writer's Cramp
Video-supervised Motor and Awareness Training in Writer's Cramp
Writer's cramp is the most common task-specific dystonia. It is characterized by involuntary co-contraction of antagonistic muscles during writing. This disabling condition may force patients to give up their occupation.
- Trial name
- NCT04611009
- Testing
- motor training, mindfulness exercises
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University Hospital Schleswig-Holstein
Dystonia
Deep Brain Stimulation in Patients With Dystonia
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN)for primary dystonia.
- Trial name
- STN DBS (NCT00773604)
- Testing
- Medtronic implantable deep brain stimulation (DBS) system
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Dystonia
Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults
Dystonia is a movement disorder seen in both children and adults that is characterized by "sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both." Secondary dystonia is far…
- Trial name
- DBSVop (NCT03078816)
- Testing
- Activa PC Primary Cell Neurostimulator - (Model 37601), Activa RC Rechargeable Neurostimulator - (Model 37612), Activa SC Single Cell Neurostimulator (Models 37602/37603)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
Isolated Cervical Dystonia, Complex Dystonia
Functional MRI and DTI in the Preoperative Assessment of Dystonia
The aim of this study is to evaluate the organization of the motor circuit in a group of patients suffering from dystonia compared with a group of healthy controls.
- Conditions
- Isolated Cervical Dystonia, Complex Dystonia, Spasticity
- Trial name
- IRMF-DIFF (NCT02877836)
- Testing
- magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Focal Hand Dystonia
IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia
This study is a multicenter, double-blind, randomized placebo controlled, parallel group, superiority trial in order to test the superiority of intramuscular injections of IncobotulinumtoxinA against placebo using a 1:1…
- Trial name
- NCT03977493
- Testing
- Xeomin
- Where
- 5 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Alain Kaelin
Dystonia
Strategy to Adapt Botulinum Toxin Doses in Dystonia
The study is designed to observ and collect the doses of botulinum toxin injected in dystonia in different centres to compare the initial dose and the dose recommended.
- Trial name
- NCT06386848
- Testing
- Botulinum toxin
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Deep Brain Stimulation, Parkinson's Disease and Parkinsonism
Sleep-specific DBS Therapy in Parkinson's Disease
Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide.
- Conditions
- Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia
- Trial name
- NCT05962489
- Testing
- Clinically optimized deep brain stimulation
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Minnesota