Clinical trials: Dystonic Disorders
Dystonia, Parkinson Disease
DYSCAR: Characterization of Dystonia
Dystonia is a rare disease leading to a severe handicap. It can be of primary or secondary origin. It is characterized by sustained muscle contractions, frequently causing twisting and repetitive movements or abnormal postures.
- Trial name
- NCT00361465
- Testing
- EMG and Kinematics recording
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Dystonia, Focal
Oral Zinc Supplementation to Enhance Botulinum Neurotoxin Response
Botulinum neurotoxin (BoNT) is injected into muscles for treatment of dystonia. BoNTs are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc.
- Trial name
- NCT05095493
- Testing
- Zinc Acetate
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Cervical Dystonia
Theta Burst Transcranial Focused Ultrasound as a Novel Treatment for Cervical Dystonia
This study is a single-blinded, randomized control study that aims to recruit 48 participants. Participants will be "randomized" into one of the study arms of the study: active stimulation to GPi, active stimulation to DN, or…
- Trial name
- NCT07690514
- Testing
- LIFUS - GPi Active, LIFUS - DN Active
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Robert Chen
Cerebral Palsy, Mixed, Cerebral Palsy, Spastic
Movement Characterization in Spastic/Dystonic Cerebral Palsy Using Haptic Feedback in Virtual Reality
This game-like intervention using virtual reality will provide an objective and quantitative characterization of dystonia and spasticity presentations in cerebral palsy, even if combined, through the process of motor learning.
- Trial name
- NCT03744884
- Testing
- Force efforts with haptic feedback in virtual reality.
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Torticollis
Is Home Positioning Time Associated With Torticollis Rate of Recovery?
The term torticollis is Latin for "twisted neck". It can be caused by a tightness of the sternocleidomastoid muscle manifested by a head tilt to the same and neck rotation to the opposite side.
- Trial name
- NCT00347334
- Testing
- infant home positioning
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Myoclonus Dystonia
Efficacy Trial of Zonisamide for Myoclonus Dystonia
Myoclonus Dystonia is a disease in which myoclonus distort the precision of movements and so cause a handicap in the movements of the everyday life.
- Trial name
- EpsilonZêta (NCT01806805)
- Testing
- zonegran
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laryngeal Dystonia, Spasmodic Dysphonia
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05216770
- Testing
- Brain imaging, Laryngeal sensory block with topical bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Cervical Dystonia
Tele-yoga and Dystonia
The purpose of this study is to investigate the effect of yoga delivered remotely on adults with dystonia. This work will have implications related to physical interventions symptom management and quality of life as well as…
- Trial name
- NCT04348669
- Testing
- Tele-yoga
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson's Disease, Dystonia
Perceptual Decision Making Under Conditions of Visual Uncertainty
In this proposal the investigators have three Specific Aims using human patient populations as model systems; 1) identify a role for the Basal Ganglia (BG) in perceptual decision making; 2) determine whether the Basal Ganglia…
- Conditions
- Parkinson's Disease, Dystonia, Ataxia
- Trial name
- NCT01845883
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dystonia, Dystonic Disorder
Meditoxin® Treatment in Patients With Cervical Dystonia
To determine the efficacy and safety of Meditoxin in subjects with cervical dystonia compared with placebo (normal saline)
- Trial name
- NCT03232320
- Testing
- Meditoxin
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Medy-Tox
Adult Cerebral Palsy
Efficacy and Safety of Meditoxin® Injection for Cervical Dystonia in Adults With Cerebral Palsy
This study aimed to compare the efficacy and safety of Meditoxin® injection for cervical dystonia in adults with cerebral palsy. It is a placebo controlled, Cross-over, Double blind, Randomized, Clinical trial.
- Trial name
- ATHETOID_CD (NCT01860196)
- Testing
- Meditoxin, Normal saline
- Volunteers
- 17 people
- Sponsor
- Seoul National University Hospital
Dry Eye Syndromes, Meige Syndrome
Wumeiwan Jiawei Fang Use in Patients With Blepharospasm
To evaluate the efficacy and safety of Jing Fang Wu Mei Wan Jiawei Fang in the treatment of idiopathic blepharospasm using a clinical randomized controlled trial method.
- Conditions
- Dry Eye Syndromes, Meige Syndrome, Blepharospasm, Hyperactivity
- Trial name
- NCT05618470
- Testing
- Wumeiwan Jiawei Fang, botulinum toxin A
- Where
- China
- Volunteers
- 80 people
- Sponsor
- China Academy of Chinese Medical Sciences
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
Parkinson s Disease, Dystonic Disorders
Genetics of Motor Learning
Background: New studies in human genetics have revealed information about genetic connections to memory and motor behavior. Researchers are interested in investigating the role of genetics in motor learning, in conjunction with…
- Conditions
- Parkinson s Disease, Dystonic Disorders, Focal Dystonia, Movement Disorders
- Trial name
- NCT01105845
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Writer's Cramp
Sensorimotor Mapping in Patients With Writer's Cramp
Writer's cramp (WC) is a form of focal dystonia, a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive movements, postures, or both.
- Trial name
- IWCToxin (NCT03085745)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Dystonia, Deep Brain Stimulation
Dystonia Image-based Programming of Stimulation: A Prospective, Randomized, Double-blind Crossover Trial
The primary objective of this exploratory study is to prospectively evaluate the feasibility of image-guided programming of pallidal deep brain stimulation (DBS) for dystonia.
- Trial name
- DIPS (NCT05097001)
- Testing
- DBS programming
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Wuerzburg University Hospital
Dystonia, Primary
Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate…
- Trial name
- AGENT10 (NCT03351218)
- Testing
- Behavioral testing - computerized tasks
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dystonia, Movement Disorder
Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia
The purpose of this randomized, double blind, multi-center study is to assess the efficacy and safety of bilateral pallidal deep brain stimulation in patients with tardive dystonia.
- Trial name
- NCT00331669
- Testing
- deep brain stimulation
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Charite University, Berlin, Germany