Clinical trials: Dysbiosis
Anorexia Nervosa
Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
This study will investigate the link between the gut microbiota, the occurrence of the central adiposity phenotype, and the patients' fear to regain weight in anorexia nervosa.
- Trial name
- DIAMOnDS (NCT06043154)
- Testing
- Patients with severe to extreme anorexia nervosa admitted to hospital for refeeding
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Disbiosis, Abdominal Pain
Evaluation of the Beneficial Effects of a Probiotic Product in Healthy Adult Subjects.
A randomized, double-blind, placebo-controlled, cross-over trial performed at one centre in Italy to explore the ability of a multistrain probiotic mixture, to modulate markers of inflammation and intestinal barrier function and…
- Conditions
- Disbiosis, Abdominal Pain, Constipation, Diarrhea
- Trial name
- NCT03234452
- Testing
- Lactoflorene plus
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefarmaco OTC SpA
Inflammatory Bowel Diseases, Ulcerative Colitis
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT04828031
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
Axial Spondyloarthritis
Optimizing Anti-IL17 Antibody Therapy by Associating Fiber Supplementation to Correct Treatment-aggravated Gut Dysbiosis in Axial Spondyloarthritis - RESPOND-IL17
Fiber is the main source of energy for colonic bacteria and its consumption favorably modifies the composition of the microbiota in only a few days. Their fermentation in the colon releases short-chain fatty acids (SCFAs).
- Trial name
- RESPOND-IL17 (NCT05812157)
- Testing
- Daily dietary supplementation with Fibruline, Anti-IL-17 therapy
- Where
- 3 sites in France
- Volunteers
- 76 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bone and Joint Infection
InterventiOnal Study of Bone and Joint Infections Related Gut dysbiosIS
Gut dysbiosis is an intestinal disorder that is characterized by accumulation of microbiota imbalance, host-microbiota crosstalk dysfunction and inflammation.
- Trial name
- OSIRIS (NCT03011502)
- Testing
- Biological samples collection of blood and feces
- Where
- 5 sites in France
- Volunteers
- 62 people
- Sponsor
- MaaT Pharma
Eating Disorders Symptoms
Effects of Fecal Microbiota Transplantation
The intestinal microbiota plays an essential role in digestion and, through the gut-brain axis, in the regulation of weight gain and eating behavior.
- Trial name
- Transmic-TCA (NCT07196189)
- Testing
- Patients, healthy volunteer
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Congenital Heart Disease, Intestinal Disease
Effect of Probiotics on Patients With Congenital Heart Disease Following Cardiopulmonary Bypass
A randomized, controlled study including infants with non-cyanosis congenital heart disease (CHD) in need of surgical correction involving cardiopulmonary bypass (CPB) was established.
- Conditions
- Congenital Heart Disease, Intestinal Disease, Dysbiosis
- Trial name
- NCT06295575
- Testing
- probiotics containing Bifidobacterium infantis and Lactobacillus
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Nanjing Children's Hospital
Bacterial Vaginosis, Vaginal Dysbiosis
AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth
Preterm birth is a major cause of mortality and long-term disability. Bacterial vaginosis (BV) is a frequent form of dysbiosis that is often asymptomatic and increases the risk of preterm birth.
- Conditions
- Bacterial Vaginosis, Vaginal Dysbiosis, Premature Delivery
- Trial name
- AUTOP 2 (NCT06349122)
- Testing
- Vaginal flora abnormalities screening and quantification using molecular biology technique, Azithromycin, Ceftriaxone
- Volunteers
- 1,794 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Arterial Stiffness, Dysbiosis
Lifestyles, Arterial Aging and Intestinal Microbiota (MIVAS III Study)
This is an observational cross-sectional study whose objective is to analyse associations between the intestinal and salivate microbiota with lifestyles (eating patterns, physical activity, tobacco and alcohol consumption)…
- Trial name
- NCT04924907
- Where
- 2 sites in Spain
- Volunteers
- 1,015 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Dysbiosis
Analysis of Microbiota Variations in Industry Workers Working Different Shifts and Impact of a Nutritional Intervention
Shift workers are a growing population. It is well established that these workers face an increased risk of developing chronic diseases, but the underlying mechanisms remain debated.
- Trial name
- NCT04918537
- Testing
- Walnuts
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sophie Bucher Della Torre
Irritable Bowel Syndrome
Tritordeum-based Foods for IBS Symptoms
People with irritable bowel syndrome (IBS), especially those with diarrhea (IBS-D), often describe worsening symptoms after eating certain foods.
- Trial name
- TritoinIBS (NCT05307185)
- Testing
- Tritordeum-based food
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Dysbiosis, Gut -microbiota
Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery
This study aims to evaluate whether probiotics can help maintain a healthy gut microbiome in patients receiving prophylactic antibiotics during elective orthopedic surgery.
- Conditions
- Dysbiosis, Gut -microbiota, Microbiome Analysis, Probiotic
- Trial name
- NCT06791993
- Testing
- Probiotic with Human Milk Oligosaccharides (HMO)
- Where
- 6 sites in United States, Thailand and 1 more
- Volunteers
- 60 people
- Sponsor
- Acibadem Maslak Hospital
Obesity, Dysbioses
Use of Probiotic Yogurt in Obese Women
This study aimed to examine the effects of using probiotic yogurt on body components (body weight, height, etc.) and digestive system (distention, gas, etc.) in obesity (obese women), which is an important public health problem…
- Trial name
- NCT05364814
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Yuksek Ihtisas University
Cystic Fibrosis Pulmonary Exacerbation
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis
The aim objective is to identify markers of bacterial, viral and fungal pulmonary dysbiosis, associated with the occurrence of exacerbation in patients followed for cystic fibrosis.
- Trial name
- DYSBIOSE-CF (NCT03569904)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pulmonary Arterial Hypertension
Angiotensin Converting Enzyme (ACE2), Brain, Gut Dysbiosis in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is fatal with right heart failure due to raised pulmonary vascular pressure. Gut dysbiosis was identified in animals with pulmonary hypertension.
- Trial name
- NCT04104490
- Where
- 2 sites in United States, Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Florida