Clinical trials: Dry Eyes
Dry Eye, Ocular Surface Disease
Evaluation of Lacrifill
Dry Eye Disease is defined as "a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface.
- Conditions
- Dry Eye, Ocular Surface Disease, Cataract Surgery, Eyes Dry Feeling of
- Trial name
- NCT07796178
- Testing
- Lacrifill, Saline
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Eye Research Associates, LLC
Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE)
Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases
This is an open-label, single-dose, prospective, monocenter, Phase I interventional study (not first-in-human) to assess the safety, tolerability, and preliminary efficacy of autologous anti-CD19 CAR-T cells as an advanced…
- Conditions
- Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Sjogren's Disease With Dry Eyes, Systemic Sclerosis (SSc)
- Trial name
- CELL-ATTACK 1 (NCT07544225)
- Testing
- anti-CD19 CAR-T cells
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Dry Eye, Eye Diseases
Autologous Serum Tears With Hyaluronate vs Balanced Salt Solution for Moderate-to-Severe Dry Eye
This study aims to find out whether adding sodium hyaluronate, a moisturizing ingredient commonly found in artificial tears, makes autologous serum eye drops more effective for treating moderate-to-severe dry eye disease.
- Conditions
- Dry Eye, Eye Diseases, Eyes Dry Chronic
- Trial name
- NCT07413172
- Testing
- Autologous Serum Tears (50% Autologous Serum Tears + 0.2% Sodium Hyaluronate), Biological - Autologous Serum Tears (50% Autologous Serum Tears + Balanced Saline Solution (BSS), Standard of Care (SOC) Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Dry Eye Symptoms, Allergic Conjunctivitis of Both Eyes
Kelulut Honey for Allergic Conjunctivitis and Dry Eye Symptoms
The goal of this clinical trial is to learn if oral Kelulut honey works to improve eye symptoms in adults with allergic conjunctivitis. It will also look at how safe Kelulut honey is when taken as a daily supplement.
- Trial name
- NCT07273747
- Testing
- Kelulut Honey 60 g Oral Supplement, Kelulut Honey 120 g Oral Supplement
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
Dry Eye, Eye Diseases
Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work
This 1-month, 3-visit study will be conducted at the Southern College of Optometry (Memphis, TN), Kannarr Eye Care, LLC (Pittsburg, KS) and Complete Eye Care of Medina (Minneapolis, MN).
- Conditions
- Dry Eye, Eye Diseases, Eyes Dry Chronic
- Trial name
- TRYPTYR ADL (NCT07266948)
- Testing
- Acoltremon
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Southern College of Optometry
Dry Eye, Dry Eyes Chronic
Switching From Xiidra to TRYPTYR
To determine the efficacy of switching participants who are being treated with Xiidra to acoltremon 0.003%. Hypothesis: Switching to acoltremon 0.003% will greatly improve the signs and symptoms of participants who were being…
- Conditions
- Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes, Eye Diseases
- Trial name
- NCT07267481
- Testing
- acoltremon 0.003%
- Volunteers
- 100 people
- Sponsor
- Southern College of Optometry
Healthy, Dry Eyes
Topical Menthol For Tear Secretion
Tears are the natural way to keep eyes moist, and tears are important for good vision and healthy eyes. Eyes without enought tears get dry and sore.
- Trial name
- TMTS (NCT07109609)
- Testing
- Topical application of 20% menthol solution in MCT oil.
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Reinhold Vieth
Aqueous Tear Deficiency, Meibomian Gland Dysfunction of Bilateral Eyes (Disorder)
Eyelid Androgen Treatment in Dry Eye
The purpose of this research study is to evaluate the effectiveness and safety of applying androgen sex hormone (i.e., testosterone) gel on the eyelids in the treatment of dry eye patients.
- Trial name
- NCT06154200
- Testing
- Testosterone gel 4.5%, Vehicle gel
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Dry Eye, Dry Eyes Chronic
Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.
This is a phase I clinical study to evaluate the safety and tolerability of PRO-190 ophthalmic solution through the incidence of unexpected adverse events, changes in Best Corrected Visual Acuity (BCVA), changes in ocular surface…
- Conditions
- Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- NCT06379685
- Testing
- PRO-190, Systane Ultra®
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema
Cool vs Room-temperature Artificial Tears
Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort.
- Conditions
- Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye, Cystoid Macular Edema
- Trial name
- NCT05832996
- Testing
- Refresh Plus Preservative-free Lubricant Eye Drops
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes
CDL Validation Study
Ocular surface photography is significantly limited in standardization and reproducibility. This reduces its applicability for clinical monitoring of acute or chronic disease.
- Conditions
- Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes, Limbal Stem-cell Deficiency, Eye Lesion
- Trial name
- NCT05461469
- Where
- Austria
- Volunteers
- 104 people
- Sponsor
- Occyo GmbH
Meibomian Gland Dysfunction, Eyes Dry Chronic
iLux Treatment for Meibomian Gland Dysfunction
Summary: Purpose: To compare the safety and efficacy of eyelid treatment with the ILux®-MGD Treatment System in one session versus five sessions of mechanical meibomian gland expression (MMGE) in patients with moderate to severe…
- Trial name
- MGD (NCT06278584)
- Testing
- iLUX Treatment System
- Where
- Colombia
- Volunteers
- 130 people
- Sponsor
- Clínica de Oftalmología de Cali S.A
Dry Eyes
Virgin Coconut Oil Contact Lens as Ocular Rewetting Agent
This is a clinical trial where 44 subjects dry eyes were instilled with Virgin Coconut Oil (VCO CL) using contact lenses as its vehicle.
- Trial name
- VCOCL (NCT06071780)
- Testing
- organic product - Virgin Coconut Oil
- Where
- Malaysia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Dry Eyes Chronic
Clinical Efficacy of Amniotic Membrane Extract Eye Drops in Dry Eye Treatment
This prospective longitudinal study aims at evaluating the clinical efficacy of human amniotic fluid extract eye drops in the treatment of dry eye disease.
- Trial name
- NCT05169931
- Testing
- RegenerEyes
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dry Eye, Dry Eye Syndromes
Effect of Lifitegrast 5% on Tear Film Markers
The purpose of this study is to assess the duration of time (in weeks) for improvement in objective dry eye markers for people who are placed on lifitegrast 0.5% (Xiidra®), an FDA-approved therapy for dry eyes.
- Conditions
- Dry Eye, Dry Eye Syndromes, Dry Eyes Chronic
- Trial name
- NCT03952481
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Dry Eyes Chronic
Intense Pulsed Light Study for Dry Eye Disease
This study will evaluate the efficacy of intense pulsed light (IPL) therapy for the treatment of dry eye disease. One eye of the participant will be randomized to receive the IPL treatment.
- Trial name
- NCT03089580
- Testing
- Intense Pulsed Light Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
Sjogren's Syndrome, Autoimmune Diseases
Examining the Immunological Process of Autoimmune Patients
Sjögren's syndrome (SjS) is an autoimmune disease characterized primarily by exocrine gland dysfunction, specifically of the salivary and lacrimal glands, resulting in dry mouth and dry eyes symptoms.
- Conditions
- Sjogren's Syndrome, Autoimmune Diseases, Dry Eyes, Dry Mouth
- Trial name
- NCT02123147
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Glaucoma, Dry Eyes
Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients
Research indicates that many people who are being treated for glaucoma have dry eyes. The purpose of this study is to test the use of artificial tears to alleviate dryness signs and symptoms in people who are using medication to…
- Trial name
- IVES (NCT01682460)
- Testing
- Refresh Tears Lubricant Eye Drops (Allergan)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Waterloo
Dry Eyes, Sjogren's Disease With Dry Eyes
Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
To investigate if fresh finger prick autologous blood (FAB) instead of serum from venesection, is a safe and effective treatment for dry eyes and corneal ulcers/ epithelial defects.
- Conditions
- Dry Eyes, Sjogren's Disease With Dry Eyes, Persistent Corneal Epithelial Defects, Chronic Corneal Ulcers
- Trial name
- FAB (NCT02153515)
- Testing
- Your own ( autologous) finger prick of blood produced with a diabetic lancet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust