Clinical trials: Drug-Induced Liver Injury
Acute Liver Failure, Drug-Induced Liver Injury
Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure
Acute liver failure (ALF) is a serious condition in which the liver suddenly stops working, often leading to life-threatening complications.
- Trial name
- NCT06872372
- Testing
- N-Acetylcysteine (NAC) Treatment, Standard supportive care
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Lahore General Hospital
Cannabidiol, Drug Induced Liver Injury
Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions
Cannabidiol (CBD) is available as a prescription drug product for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex.
- Conditions
- Cannabidiol, Drug Induced Liver Injury, Drug Interaction
- Trial name
- NCT06192589
- Testing
- Cannabidiol, Citalopram, Morphine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Liver Injury, Drug-Induced
Clarify of Predictive Risk Factors of Chemotherapy-induced Liver Injury
The most common toxicity of TP (docetaxel and cisplatin) chemotherapy is chemotherapy-induced liver injury. However, patients don't always experience same chemotherapy-induced liver injury for the same drugs.
- Trial name
- NCT03069820
- Testing
- docetaxel and cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Hepatitis, Tuberculosis
Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity
The purpose of the study is to estimate plasma drug levels ( free and total drug levels ) of rifampicin and other antituberculosis drugs and compare these drug levels in patients who develop drug induced hepatotoxicity versus…
- Trial name
- NCT01456845
- Where
- India
- Volunteers
- 110 people
- Sponsor
- All India Institute of Medical Sciences
Drug-Induced Acute Liver Injury
The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI
The study adopted the design of multi-center, randomized, double-blind, positive control drug, superiority test, using the double-blind double-simulating skills.
- Trial name
- NCT05063500
- Testing
- bicyclol, 25mg/ tablet, polyene phosphatidylcholine capsules, 228mg/ particle.
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Drug Induced Liver Disease Study Group
Drug-induced Liver Injury, Gut Microbiota
Alterations of Gut Microbiota and Serum Biochemical Markers in DILI Patients
Drug-induced liver injury is a leading cause of acute liver failure worldwide and one of the least understood areas in hepatology research.
- Conditions
- Drug-induced Liver Injury, Gut Microbiota, Biochemical Markers
- Trial name
- NCT05465642
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Virus Disease
Collection of Liver Tissue for Virologic Studies
This study will examine liver tissue to investigate the role of viral infections in fulminant hepatitis, liver failure, and profound bone marrow failure.
- Trial name
- NCT00005936
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Drug Induced Liver Injury
Prospective Comparative Validation Study of RUCAM and RECAM
A total of 407 hospitalized patients with acute liver injury in Beijing Friendship Hospital Affiliated to Capital Medical University were enrolled.
- Trial name
- NCT06771011
- Where
- China
- Volunteers
- 407 people
- Sponsor
- Beijing Friendship Hospital
Drug-induced Disorder of Liver, Adverse Reaction to Drug
Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity
Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults).
- Trial name
- NCT02353455
- Testing
- Blood sampling
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Andreas Benesic, MD
Drug-Induced Acute Liver Injury
The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI
The study adopted the superiority design of multi center, randomized, double-blind, positive control drug, dose finding, using two simulation skills.
- Trial name
- NCT02944552
- Testing
- bicyclol tablet 25mg, bicyclol tablet 50mg, polyene phosphatidylcholine capsule 456mg
- Where
- 17 sites in China
- Volunteers
- 244 people
- Sponsor
- Drug Induced Liver Disease Study Group
Acute Drug-induced Liver Injury, Chronic Liver Disease
A Diagnostic Study on Patients With Drug-induced Liver Injury
This study is a multi-center, prospective, non-interventional cohort study with an estimated enrollment of 600 patients with acute DILI.
- Trial name
- NCT04526548
- Volunteers
- 600 people
- Sponsor
- Drug Induced Liver Disease Study Group
Drug-Induced Liver Injury
A Real World Study of Polyene Phosphatidylcholine Injection for the Prevention and Treatment of DILI in Patients With Malignant Hematological Diseases
This is a retrospective, multicenter real-world observational study. Its main goal is to find out if Polyene Phosphatidylcholine Injection works to treat drug-induced liver injury (DILI) in adults with hematologic malignancies…
- Trial name
- PPC-HM-DILI (NCT07476885)
- Testing
- polyene phosphatidylcholine
- Volunteers
- 1,000 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Hepatitis, Drug-Induced
Treatment Efficacy of Corticosteroids and Mycophenolate Mofetil in Patients With Immune Related Hepatitis
This clinical trial is to clarify and investigate the patterns of immune-related hepatitis and the optimal treatment choice for patients who are steroid-dependent.
- Trial name
- I-HEP (NCT04810156)
- Testing
- Mycophenolate Mofetil, Solu-Medrol, Ursodeoxycholic acid
- Where
- 5 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Inge Marie Svane
Drug Induced Liver Injury, Tuberculosis (TB)
Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi
OBJECTIVE : To compare the outcome of treatment with silymarin or N-acetyl cysteine in patients taking anti-tuberculous drugs for tuberculosis at Tertiary Care Hospital, Karachi.
- Trial name
- NCT07058090
- Testing
- Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
- Volunteers
- 410 people
- Sponsor
- Liaquat National Hospital & Medical College
Hepatitis, Toxic
Cholestatic Drug-induced Liver Injury
Cholestatic drug-induced liver injury (DILI) is the severe form of DILI with a grave outcome. Drug-metabolizing enzymes play an important role in the metabolism of drugs.
- Trial name
- DILI (NCT01141322)
- Testing
- Ursodeoxycholic Acid
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Drug Induced Liver Injury, Drug-Induced Kidney Injury
A Multicenter Observational Study on Safety of the Herbal Medicines at Inpatient Setting
Prospective observations on safety of the herbal medicines regarding liver and kidney injuries at inpatient setting of four sites in South Korea which are located at each quadrant of the country.
- Conditions
- Drug Induced Liver Injury, Drug-Induced Kidney Injury, Herbal Medicine Adverse Reaction
- Trial name
- NCT04269486
- Where
- South Korea
- Volunteers
- 287 people
- Sponsor
- Korea Institute of Oriental Medicine
Healthy
Exploration of microRNA and Metabolomics Biomarkers Predicting Drug Induced Liver Injury in Elderly People
An open-label, one-sequence, multiple administration study for exploration of microRNA and metabolomics biomarkers to predict drug induced liver injury in healthy elderly Korean people.
- Trial name
- NCT02431832
- Testing
- Augmentin tab
- Where
- South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Paracetamol Overdose
The Markers and Paracetamol Poisoning Study 2
Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission.
- Trial name
- MAPP2 (NCT03497104)
- Testing
- Surplus blood tests
- Where
- United Kingdom
- Volunteers
- 464 people
- Sponsor
- NHS Lothian
Drug-induced Liver Injury,Chronic
Efficacy and Safety of Glucocorticosteroid Treatment in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of glucocorticosteroid treatment in the patients with chronic recurrent drug-induced liver injury (DILI).
- Trial name
- NCT02651350
- Testing
- Methylprednisolone, Standard Treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing 302 Hospital