Clinical trials: Drug Intolerance
Drug Interactions, Primary Prevention
LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering
Drug-drug interactions often limit statin optimization in a population of patients prescribed cytochrome P3A4 inhibitors, which include immunosuppressive agents, protease inhibitors, and antifungals.
- Conditions
- Drug Interactions, Primary Prevention, Cardiometabolic Syndrome, LDL-Cholersterol Lowering
- Trial name
- SOLVE-LDL-C (NCT06865885)
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Pre Diabetes
Can Brisk Walking Combined With Ingestion of a Lipid-lowering Drug Improve Fat Metabolism in Muscle?
Briefly, participants will be assessed for their eligibility for the study using an oral glucose tolerance test, which involves drinking a sugary drink followed by a series of small blood samples.
- Trial name
- NCT03804892
- Testing
- Body Composition, Maximal aerobic fitness test, Oral glucose tolerance test
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Liverpool John Moores University
Rheumatoid Arthritis (RA)
TLL-018 in Patients With Moderate to Severe Active Rheumatoid Arthritis With Inadequate Response or Intolerance to csDMARDs
This is a randomized, double-blind, placebo-controlled parallel-group Phase II study. The study aims to evaluate the efficacy and safety of TLL-018 in adult patients with moderate to severe active rheumatoid arthritis who have…
- Trial name
- NCT07748728
- Testing
- TLL-018
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Hangzhou Highlightll Pharmaceutical Co., Ltd
HIV Infections, Pregnancy
Problems Associated With the Use of Anti-HIV Drugs in HIV-Infected Pregnant Women
The purpose of this study is to find out if HIV-infected pregnant women who take protease inhibitors (PIs) are more likely to have blood sugar problems than those who do not take PIs.
- Trial name
- NCT00017797
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 160 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Smoking Cessation
Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV
Smokers living with HIV represent a major health disparity population in the United States and the world more generally. Major contributing factors to the maintenance and relapse of smoking among smokers living with HIV include…
- Conditions
- Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking
- Trial name
- NCT03904186
- Testing
- QUIT, Time-Matched Control (TM)
- Where
- 3 sites in United States
- Volunteers
- 131 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
A Study of ddI in Children With AIDS Who Have Not Had Success With Zidovudine
The purpose of this study is to make didanosine (ddI) available to children with AIDS who are clinically deteriorating on zidovudine (AZT) or intolerant to AZT and cannot enter the Phase II ddI programs due to protocol exclusion…
- Trial name
- NCT00002280
- Testing
- Didanosine
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
Obesity, Pre-diabetes
Chromium Effects on Insulin and Vascular Function in People at Risk for Diabetes
The purpose of this study is to investigate the effects of Chromium on glucose tolerance and endothelial function in people at risk for type II diabetes.
- Conditions
- Obesity, Pre-diabetes, Insulin Resistance, Impaired Glucose Tolerance
- Trial name
- NCT00067626
- Testing
- Chromium
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Griffin Hospital
Cold Hypersensitivity
Efficacy and Safety of Sipjeondaebo-tang on Korean Patients With Cold Hypersensitivity in the Hands and Feet (SDT)
Gachon University, Gil Oriental Medicine Center
- Trial name
- NCT03374345
- Testing
- Sipjeondaebo-tang Granule
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gachon University Gil Oriental Medical Hospital
Drug Intolerance
Statin Immune Study
Statins are widely used drugs to treat hypercholesterolaemia. In general, they are very safe drugs. However, up to one third of statin users can experience muscle symptoms, which are most commonly mild without any conventional…
- Trial name
- ImmunoStat (NCT02984293)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Pre-Diabetes, Metabolic Syndrome
Integrating Lifestyle Therapy for Diabetes Prevention Into Primary Care
An educational intervention in the General Medicine Clinic aimed at both primary care providers (PCPs) and their patients with metabolic syndrome/pre-diabetes (MetSyn/PDM).
- Conditions
- Pre-Diabetes, Metabolic Syndrome, Type 2 Diabetes
- Trial name
- NCT00853801
- Testing
- Lifestyle intervention and provider feedback
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Cook County Health
Orthostatic Hypotension, Postprandial Hypotension
Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.
- Trial name
- HOPE65 (NCT07485998)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Arthritis, Rheumatoid
Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor
Phase 2 study of the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of KPL-404 in subjects with moderate to severe Rheumatoid Arthritis.
- Trial name
- NCT05198310
- Testing
- KPL-404
- Where
- 42 sites in United States, Bulgaria and 5 more
- Volunteers
- 145 people
- Sponsor
- Kiniksa Pharmaceuticals, Ltd.
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the safety and effectiveness of adding alogliptin, once daily (QD), compared to glipizide with metformin in diabetic patients.
- Trial name
- ENDURE (NCT00856284)
- Testing
- Alogliptin, Metformin, Glipizide
- Where
- 261 sites in United States, Argentina and 30 more
- Volunteers
- 2,639 people
- Sponsor
- Takeda
Glucose Control, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Eating Almonds Before a Meal to Control Blood Sugar
The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation.
- Conditions
- Glucose Control, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Precision Medicine, Nutrition
- Trial name
- NUTS (NCT07603739)
- Testing
- Premeal almond ingestion
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
This Study is Designed to Collect Treatment Data of Thai Children on Third Line ARV Therapy
Third Line Highly Active Antiretroviral Therapy (HAART) in HIV-infected Children
This is an observational cohort study of virologic and immunologic outcome after at least 48 weeks of third line antiretroviral therapy. Upto 150 children at 8 Thai sites will be enrolled.
- Trial name
- NCT01225406
- Testing
- Tenofovir
- Where
- 9 sites in Thailand
- Volunteers
- 56 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Asthma Aspirin-sensitive, ASA Intolerant Asthma
Challenge Test for Acetylsalicylic Acid Hypersensitivity
The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of…
- Conditions
- Asthma Aspirin-sensitive, ASA Intolerant Asthma, Asthma, Aspirin-Induced, Asthma, Nasal Polyps, and Aspirin Intolerance
- Trial name
- NCT01681615
- Testing
- Acetylsalicylate, Isotonic NaCl
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Statin Therapy, Statin Adverse Reaction
DESIFOR-EXPAND (MHIF)
The DESIFOR pilot study was conducted to determine the feasibility of utilizing an n-of-1 trial to facilitate tolerance of unblinded rosuvastatin in patients with prior statin intolerance
- Conditions
- Statin Therapy, Statin Adverse Reaction, Statin
- Trial name
- NCT06804980
- Testing
- Rosuvastatin (Crestor)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Minneapolis Heart Institute Foundation
Type 2 Diabetes Mellitus
Efficacy and Safety of Alogliptin Combined With Pioglitazone in Treating Subjects With Type 2 Diabetes Mellitus.
The purpose of this study is to evaluate the safety and efficacy of alogliptin, once daily (QD), taken in combination with pioglitazone in adults with type 2 diabetes mellitus.
- Trial name
- NCT00328627
- Testing
- Alogliptin, Pioglitazone
- Where
- 90 sites in United States, Australia and 17 more
- Volunteers
- 1,554 people
- Sponsor
- Takeda
Pre-diabetes
Can the Health Benefits of a Walking-based Exercise Programme be Enhanced by Co-ingestion of a Lipid-lowering Drug?
Study investigates the hypothesis that an exercise programme of steady walking will have larger effects on insulin sensitivity and glycemic control when combined with Acipimox intake prior to each exercise session in people with…
- Trial name
- NCT03809793
- Testing
- Exercise Program, DXA, MRI
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Liverpool John Moores University