Clinical trials: Drug Dose
Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria
Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin
This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney…
- Conditions
- Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria, Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
- Trial name
- CRYSTALLINE (NCT07772752)
- Testing
- Crystalluria examination
- Where
- Belgium
- Volunteers
- 290 people
- Sponsor
- Universitair Ziekenhuis Brussel
Drug Dose
Pediatric Drug Dose Calculation
This study is a randomized controlled trial that aimed to investigate the effect of a web-supported interactive learning program on the knowledge level of nursing students about pediatric drug dose calculation.
- Trial name
- NCT07305233
- Testing
- Study Group
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ege University
Body Weights and Measures, Body Weight in the Overweight and Obese Class - I Population
Machine Learning and 3D Image-Based Modeling for Real-Time Body Weight and Body Composition Estimation During Emergency Medical Care. Study 3
The goal of this randomized controlled clinical trial is to compare standard methods of weight estimation and drug dose calculations against weight estimates and dose calculations using a 3D camera weight estimation system in…
- Conditions
- Body Weights and Measures, Body Weight in the Overweight and Obese Class - I Population, Drug Dose, Weight Estimate
- Trial name
- NCT06645548
- Testing
- Weight estimation using 3D camera
- Sponsor
- Florida Atlantic University
Pain, Postoperative, Analgesic Effect
Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty is a commonly performed orthopaedic surgery for the treatment of end-stage osteoarthritis when conservative management becomes ineffective.
- Conditions
- Pain, Postoperative, Analgesic Effect, Total Knee Arthroplasty, Liposomal Bupivacaine
- Trial name
- NCT06740214
- Testing
- 0.5% standard bupivacaine only, 1.33% liposomal bupivacaine with 0.5% standard bupivacaine, 1.33% liposomal bupivacaine only
- Where
- Hong Kong
- Volunteers
- 177 people
- Sponsor
- The University of Hong Kong
No Specific Conditions, Weight, Body
Machine Learning and 3D Image-based Modeling for Body Weight Estimation.
The goal of this randomized controlled clinical trial is to [learn about, test, compare etc.] in critically ill or injured cohorts of patients presenting to the Emergency Department.
- Conditions
- No Specific Conditions, Weight, Body, Drug Dose, Weight-Estimation
- Trial name
- NCT06281938
- Testing
- Weight estimation using 3D camera, Standard care weight estimation
- Volunteers
- 320 people
- Sponsor
- Florida Atlantic University
Healthy Volunteers, Aerosol Therapy
Inhaled Dose Analysis Using a Breath Actuated Nebulizer in Healthy Subjects
The goal of this crossover study is to compare urine drug concentrations using a continuous vibrating mesh nebulizer versus a breath-actuated vibrating mesh nebulizer in healthy volunteers.
- Conditions
- Healthy Volunteers, Aerosol Therapy, Inhaled Drug Dose, Pharmacogenomic Drug Interaction
- Trial name
- NCT06157515
- Testing
- Breath-actuated vibrating mesh nebulizer, Continuous vibrating mesh nebulizer
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Maximum Tolerated Dose, GIST
Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)
This is a single-arm, two cohort, open label phase I/II clinical trial studying the combination of oral imatinib 400 mg, once daily, and oral selinexor given once weekly (Cohort A); and single-agent oral selinexor 60 mg BIW…
- Conditions
- Maximum Tolerated Dose, GIST, Metastatic Adult Soft Tissue Sarcoma, Drug Toxicity
- Trial name
- SeliGIST (NCT04138381)
- Testing
- Selinexor, Imatinib
- Where
- 6 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Dose Response Relationship, Drug
Infiltration Effect on SUV
A widely used semi-quantitative parameter to assess tumor status is the standardized uptake value (SUV). SUV estimation accuracy can be impacted by many variables.
- Trial name
- NCT03320564
- Testing
- F-18 FDG PET
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Adrenaline; Aortic Dissection; Drug Dose; Nervous System; Ischemia Reperfusion Injury
Effects of Different Doses of Epinephrine on Biomarkers of Nervous System Ischemia-reperfusion Injury in Patients With Stanford Type A Dissection
Aortic dissection is the most common aortic disease leading to death. Among them, patients with Stanford type A dissection (TAAD) are prone to dissection rupture in the early stage, and their condition deteriorates rapidly.
- Trial name
- NCT05151536
- Volunteers
- 132 people
- Sponsor
- Yunlong Fan
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Inappropriate Dose of Drug Administered, Health Behavior
A Trial to De-prescribe Inappropriate Medications in the Community Dwelling Elderly
The objective of this trial is to test the beneficial effect of a pharmacist-initiated knowledge transfer intervention to both patients and prescribers on the discontinuation of inappropriate prescriptions, compared to usual…
- Trial name
- D-PRESCRIBE (NCT02053194)
- Testing
- Pharmacist-led educational intervention
- Volunteers
- 600 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Dose-Response Relationship, Drug
The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spinal anesthesia could…
- Trial name
- LOC (NCT03240055)
- Testing
- spinal anesthesia, etomidate
- Where
- China
- Volunteers
- 54 people
- Sponsor
- General Hospital of Ningxia Medical University
Dose-Response Relationship, Drug
Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial
Dexmedetomidine can prolong the duration of local anesthetics, but the effect of perineural dexmedetomidine on the potency of ropivacaine for brachial plexus blocks in pediatric patients has not been investigated.
- Trial name
- NCT02781246
- Testing
- perineural dexmedetomidine
- Volunteers
- 160 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Aged, Drug
The Effect of Age on the Median Effective Dose (ED50) of Intranasal Dexmedetomidine for Rescue Sedation Following Failed Sedation With Oral Chloral Hydrate During Magnetic Resonance Imaging
Increasing evidences suggest that dexmedetomidine Pharmacokinetic are different in children. We performed a up-down sequential allocation study to determine the ED50 for rescue sedation following sedation failures in children and…
- Conditions
- Aged, Drug, Dose-Response Relationship
- Trial name
- NCT02253199
- Testing
- intranasal dexmedetomidine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Circulation, Drug Dose
Influences of Phenylephrine, Dopamine and Ephedrine on Stroke Volume Variation and Pulse Pressure Variation
Although induced hypertension decreased SVV and PPV,the influences of stroke volume variation and pulse pressure variation caused by phenylephrine,dopamine and ephedrine were unknown.
- Conditions
- Circulation, Drug Dose, Calculated SAP
- Trial name
- NCT02201121
- Testing
- Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation
- Volunteers
- 94 people
- Sponsor
- Chinese PLA General Hospital
Adverse Effect of Oxytocic Drugs, Uterine Hemorrhage
Uterotonic Efficacy of Oxytocin 2.5 Versus 10 Units During Caesarean Section at Mulago Hospital
The purpose of the study was to determine whether 2.5 international units of oxytocin gives adequate uterine tone and is safe as compared to 10 international units of oxytocin following caesarean section delivery at Mulago…
- Conditions
- Adverse Effect of Oxytocic Drugs, Uterine Hemorrhage, Inappropriate Dose of Drug Administered
- Trial name
- NCT01726478
- Testing
- 2.5 units Oxytocin, 10 units Oxytocin
- Where
- Uganda
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Faculty of Medicine
Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug
Trial of Different Dosages' Ge Gen Qin Lian Decoction in the Treatment of Type 2 Diabetes
Ge Gen Qin Lian Decoction are one kind of Chinese prescription, and previous study showed they had antidiabetic effects on the clinical patients and no obvious toxicity was found.
- Trial name
- NCT01219803
- Testing
- High Dose GGQL Decoction, Mild dose GGQL Decoction, Low dose GGQL Decoction
- Where
- 4 sites in China
- Volunteers
- 240 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Renal Insufficiency,Chronic, Disease Progression
Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency
The primary goal of the trial was to evaluate whether the optimal antiproteinuric doses of benazepril (an ACE inhibitor) or losartan (an ARB), as compared with their conventional doses, can safely improve the long-term renal…
- Conditions
- Renal Insufficiency,Chronic, Disease Progression, Proteinuria, Dose-Response Relationship,Drug
- Trial name
- NCT00338091
- Testing
- Benazepril, Losartan
- Where
- China
- Sponsor
- Southern Medical University, China