Clinical trials: Disorders of Sex Development (DSD)
Polycystic Ovary Syndrome (PCOS), Myo-inositol
Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome
The goal of this clinical trial is to determine whether a combination of myo-inositol (MI) and D-chiro-inositol (DCI) with folic acid is more effective than placebo (Folic acid alone) in improving menstrual irregularities and…
- Conditions
- Polycystic Ovary Syndrome (PCOS), Myo-inositol, D-chiro-inositol
- Trial name
- NCT07701525
- Testing
- Myo-Inositol and D-Chiro-Inositol Combination Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Growth Hormone Deficiency, Idiopathic Short Stature
Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature
This study evaluates long-term safety and effectiveness of Growtropin®-II treatment in children with short stature.
- Conditions
- Growth Hormone Deficiency, Idiopathic Short Stature, Turner Syndrome, Small for Gestational Age
- Trial name
- NCT04798690
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Dong-A ST Co., Ltd.
Congenital Webbing of Neck
Mehri Turki Surgical Technique of the Webbed Neck
The webbed neck is one of the conspicuous deformities of Turner syndrome that presents a surgical challenge. Despite the availability of surgical techniques, surgical outcomes are not always acceptable and recurrence occurs.
- Trial name
- NCT06446791
- Testing
- Mehri Turki Surgical Technique of the Webbed Neck
- Volunteers
- 5 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism
Observe the therapeutic efficacy of human menopausal gonadotropin combining with human chorionic gonadotropin in adolescent boys with congenital hypogonadotropic hypogonadism.
- Trial name
- NCT02880280
- Testing
- Human Menopausal Gonadotropin, Human Chorionic Gonadotropin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Children's Hospital
Adrenal Hyperplasia, Congenital
Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
21-hydroxylase deficiency (21-OHD) is an inherited disorder that results from a mutation on the CYP21A2 gene. It affects the adrenal glands and is the most common cause of congenital adrenal hyperplasia (CAH).
- Trial name
- NCT00694525
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Office of Rare Diseases (ORD)
Turner Syndrome
Cardiopulmonary Exercise Testing in Girls (8-18y) with Turner Sydrome.
The goal of this clinical trial is to have a beter insight in the exercise tolerance in girls with Turner Syndrome aged 8-18 years .
- Trial name
- NCT06780514
- Testing
- Cardiopulmonary exercise test
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Congenital Adrenal Hyperplasia
Electronic Registry of Male Patients With Congenital Adrenal Hyperplasia 21-hydroxylase Deficiency
Observational, retrospective, prospective, single-center cohort study. Participation in the registry will be offered consecutively to any patient with the disease, newly diagnosed or with documented diagnosis made at another…
- Trial name
- NCT06754423
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hyperandrogenism, Glucocorticoid Metabolism
Effect of Free Fatty Acids (FFA) on Androgen Precursors in Women
The purpose of this study is to determine whether free fatty acids modify the androgen levels in healthy young women.
- Trial name
- NCT00473603
- Testing
- lipid/heparin infusion
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Endocrine Disease, Infertility
Hormonal Regulation of Puberty and Fertility
Background: The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins.
- Conditions
- Endocrine Disease, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01511588
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Kallmann Syndrome
A Study to Characterize Epidemiology, Clinical and Genetic Features of Kallmann Syndrome in Finland
Objective is to characterize epidemiology, clinical and genetic features of Kallmann syndrome in Finland.
- Trial name
- NCT00623116
- Testing
- Short withdrawal of testosterone, gonadotropins or estrogenic compounds (see below)
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital for Children and Adolescents, Finland
Addison Disease, Adrenal Hyperplasia Congenital
Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia
The aim of this study is to compare the effects of tablet treatment, circadian and combined circadian and ultradian subcutaneous hydrocortisone infusion on steroid metabolism and tissue responses to therapy.
- Trial name
- NCT02096510
- Testing
- Solu-Cortef, Cortef
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- Haukeland University Hospital
Cushing Disease Due to Increased ACTH Secretion
Combination Osilodrostat and Cabergoline in Cushing's Disease
Cushing disease remains a challenging endocrine disorder in which persistent or recurrent hypercortisolism often requires medical therapy after surgery or when surgery is not feasible.
- Trial name
- COSCA-ECD (NCT07603466)
- Testing
- osilodrostat, osilodrostat and cabergoline
- Where
- 5 sites in Iraq
- Volunteers
- 50 people
- Sponsor
- University of Basrah
Klinefelter Syndrome
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
The study seeks primarily to determine whether modulation of systemic and testicular sex steroids balance by aromatase inhibitors will positively affect the metabolic health and spermatogenesis of men with Klinefelter syndrome…
- Trial name
- KLIN-HEALTH (NCT05586802)
- Testing
- Anastrozole, Semaglutide, human chorionic gonadotropin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Georgios Papadakis
Hypogonadism
Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio, high insulin levels in the…
- Trial name
- NCT00470990
- Testing
- GnRH antagonist (Acyline)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Genetic Disorder, Turner Syndrome
Safety of Somatropin and Induction of Puberty With 17-beta-oestradiol in Girls With Turner Syndrome
This trial is conducted in Europe. The aim of this trial is to assess whether increasing doses of somatropin (Norditropin®) can maintain the initial increase in height velocity and improve final height.
- Trial name
- NCT01518062
- Testing
- somatropin, oestrogen
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Novo Nordisk A/S
Turner Syndrome, Peripheral Angiopathy
AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)
Turner syndrome is a genetic condition, rare, due to the total or partial absence of one X chromosome, affecting 1/2500 newborn female. It combines almost constantly short stature and ovarian failure with infertility.
- Conditions
- Turner Syndrome, Peripheral Angiopathy, Vascular Malformation, Lymphedema
- Trial name
- AVAST (NCT02250456)
- Testing
- Echo doppler
- Where
- 6 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Hypothalamic Obesity
Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
To study the effect of combined diazoxide-metformin therapy on body weight in youth with hypothalamic obesity following treatment for craniopharyngioma.
- Trial name
- NCT00892073
- Testing
- Diazoxide, Metformin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- The Hospital for Sick Children
Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
Men with Idiopathic Hypogonadotropic Hypogonadism (IHH) lack a hormone called gonadotropin releasing hormone (GnRH). This hormone is important for starting puberty, maintaining testosterone levels, and fertility.
- Conditions
- Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism, GnRH Deficiency
- Trial name
- NCT00493961
- Testing
- gonadotropin releasing hormone (GnRH)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Disorders of Sex Development, Hypospadias
Genetics of Differences of Sex Development and Hypospadias
This study seeks to identify genetic causes of conditions that affect the gonads and genitals, and to study the impact on families of receiving genetic results.
- Trial name
- NCT03102554
- Testing
- Return of Genetic Results
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
The aims of this study are: 1) to identify genes that play a role in human pubertal development and reproduction, 2) to characterize the phenotypic spectrum of patients with these gene defects, and 3) to discern the mode of…
- Conditions
- Hypogonadotropic Hypogonadism, Kallmann Syndrome, Puberty, Delayed, Puberty, Precocious
- Trial name
- NCT00494169
- Where
- United States
- Volunteers
- 4,042 people
- Sponsor
- Massachusetts General Hospital