Clinical trials: Discomfort
Pain
Pilot Study of the Effect of Transcutaneous Stimulation of the Vagus Nerve on Pain Perception and Parameters of the Autonomic Nervous System
The increased incidence of pain syndromes requires the investigation of pathophysiological coherences as well as searching for new therapies.
- Trial name
- NCT01174498
- Testing
- Cerbomed t-VNS® transcutaneous stimulation
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- cerbomed GmbH
Digestive System Disorders
A Study to Determine if Aquamin (as AquaCal and AquaPT) Improves Digestive Discomfort
Digestive discomfort includes gastrointestinal symptoms such as abdominal pain, altered bowel habit, flatulence and bloating and can sometimes result from slower intestinal transit and other digestive irregularities.
- Trial name
- NCT01770808
- Testing
- AquaCal, AquaPT
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University College Cork
Sedentary Behavior, Fatigue
Resistance Exercise Breaks Improve Ratings of Discomfort and Fatigue in College Students (REX)
The purpose of this investigation is to determine the impact of simple resistance exercise breaks on physical activity and prolonged sedentary behavior as well as on ratings of discomfort, fatigue, and sleepiness.
- Conditions
- Sedentary Behavior, Fatigue, Sleepiness, Pain
- Trial name
- REX (NCT04926350)
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Texas A&M University Kingsville
Nuclear Cataract
Less Discomfort and Less Pharmacology. Cataract Surgery at Physiologic Intraocular Pressure (IOP)
To investigate the impact of high vs low Intraocular Pressure (IOP) on the intraoperative experience for the patient and surgeon.
- Trial name
- NCT06325397
- Testing
- High Intraocular Pressure (IOP), Low Intraocular Pressure (IOP)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Matthew Rauen
Contact Lens Discomfort
The Effect of Eyelid Margin Debridement on Contact Lens Discomfort
In this study, clinical variables related to eyelids that potentially have an effect on contact lens discomfort will be investigated such as eyelid signs and secretions, eyelid sensitivity, eyelid microbiome, Demodex infestation…
- Trial name
- NCT03311204
- Testing
- BlephEx, Lid Hygenix
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Low Intensity Knee Gonalgia
Effect of Yogurts Supplemented With Mobilee on Joint Function in Healthy Individuals With Joint Discomfort
The purpose of this study is to determine whether the daily eating of a yogurt supplemented with Mobile is effective in improving joint function and quality of life of individuals with low intensity gonalgia.
- Trial name
- NCT01303432
- Testing
- Yogurt supplemented with Mobilee, Yogurt
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bioiberica
Chronic Low Back Pain
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements.
- Trial name
- NCT00899600
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Stress, Resilience and Mental Health of First Responders
Mindfulness in Motion Targeted to Sustaining the Mental and Physical Resilience of First Responders
High levels of chronic and recurrent workplace stress can profoundly impact the physical, mental, and emotional health of first responders.
- Conditions
- Stress, Resilience and Mental Health of First Responders, Work Engagement, Musculoskeletal Discomfort
- Trial name
- NCT07502092
- Testing
- Mindfulness in Motion for First Responders
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Abdominal Pain/ Discomfort, Slightly Constipation
Effect of Perilla Extract on Improvement on Gastrointestinal Discomfort
In the current study the effects of proprietary Perilla frutescens leaf extract in comparison to Maltodextrin, a fully digestible carbohydrate (placebo control), on gastrointestinal discomfort and bowel function were…
- Trial name
- NCT01931930
- Testing
- Perilla extract, Maltodextrin
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Amino Up Chemicals Co., Ltd.
Healthy
Effects of Kilohertz-frequency and Low-frequency Current on Triceps Surae
Neuromuscular electrical Stimulation (NMES) can minimize muscle atrophy and complications related to muscle disuse and help improve neuromuscular performance.
- Trial name
- NCT05894044
- Testing
- Russian current 10%, Aussie current 10%, Pulsed current 500 µs phase
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Pain
Electrical Stimulation Over Acupuncture Points in Reduction of Rectal Discomfort Distension
Colonoscopy is a stressful and unpleasant procedure especially during the passage of the endoscope through angulations of colon. Electro-acupuncture is one of the alternative to reduce colorectal discomfort.
- Trial name
- NCT01551654
- Testing
- Transcutaneous Electrical Nerve Stimulation (ITO Company )
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Pain, Parkinson Disease
Experimental Pain in Parkinsons
Study comparing pain intensity and discomfort in patients with Parkinson´s disease and healthy controls during inducement of mechanical, thermal, and chemical experimental pain
- Trial name
- ExPainPD (NCT05981261)
- Testing
- inducement of experimental pain
- Where
- Denmark
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Vaginal Discharge, Dyspareunia
Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Previous research has shown that semen deposition in the vagina after intercourse leads to dripping, discomfort, and vaginal odor.
- Conditions
- Vaginal Discharge, Dyspareunia, Female Sexual Dysfunction, Vaginitis
- Trial name
- NCT04885556
- Testing
- Tampon-like device for absorption of sexual fluids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Gastrointestinal Discomfort
Impact of Dietary Fibre Consumption on Digestive Comfort
The purpose of this randomised, placebo-controlled, cross-over study is to compare the impact different fibres have on gastrointestinal symptoms when they are consumed individually or as mixtures in healthy adults.
- Trial name
- Fibrecomf (NCT05830032)
- Testing
- Soluble corn fibre, Inulin, soluble corn fibre and inulin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Pain, Discomfort
Association Among Pain Perception, Severity of Temporomandibular Joint Dysfunction, and Spinal Health in Caregivers of Stroke Individuals
This study aims to examine pain perception, temporomandibular disorder severity and spine health in caregivers of stroke patients.
- Conditions
- Pain, Discomfort, Caregiver, Temporomandibular Disorder
- Trial name
- NCT06052735
- Testing
- Correlation research
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Catheter Related Complication
Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery
The investigators aimed to compare the effects of tramadol and dexmedetomidine, which are commonly used in anesthesia, on preventing catheter-related bladder discomfort.
- Trial name
- NCT04314050
- Testing
- Tramadol, Dexmedetomidine, control
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Stress Urinary Incontinence
Sexual Fonction and Discomfort in Women After Midurethral Sling Surgery, Using PPSSQ
Evaluation of the sexual quality of life of women who had a sub-urethral sling several years ago, using a recently validated questionnaire: the PPSSQ (Pelvi-Perineal Surgery Sexuality Questionnaire).
- Trial name
- SEXBSU (NCT05527665)
- Testing
- Midurethral sling surgery
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
IUD
Virtual Reality Simulation for Intrauterine Device Insertion: A Randomized Clinical Trial
Aim of this study is to evaluate the effect of VR on the patients overall experience during the IUD insertion procedure.
- Trial name
- VR-IUD (NCT04389021)
- Testing
- Virtual Reality
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Overuse Injury, Repetitive Strain Injury
Measuring the Feasibility and the Effects of Chair Massage on Pain and Discomfort in the Cardiac Sonographer
The purpose of this study is to determine whether the effects of chair massage and/or chair massage with stretching may reduce musculoskeletal pain and discomfort related symptoms associated with the job duties of a cardiac…
- Trial name
- NCT00975026
- Testing
- Massages ± Stretches
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic