Clinical trials: Discomfort
Colic
Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort
Study to determine whether hyoscine butylbromide can provide adequate symptomatic relief of a single episode - defined as lasting not longer than 1 day - and multiple episodes of abdominal pain or discomfort associated with…
- Trial name
- NCT02242292
- Testing
- Hyoscine butylbromide
- Volunteers
- 527 people
- Sponsor
- Boehringer Ingelheim
Injection Site Irritation, Injection Site Bruising
Comparison of Subcutaneous Injection of Normal Saline and Bacteriostatic Saline
This is a randomized, double-blind, single-center clinical trial comparing normal saline and bacteriostatic saline subcutaneous injection within a single subject.
- Conditions
- Injection Site Irritation, Injection Site Bruising, Injection Site Discomfort, Benzoic Acid Adverse Reaction
- Trial name
- NCT05109000
- Testing
- Sodium Chloride 0.9% Inj, Bacteriostatic Sodium Chloride 0.9 % INJECTION VIAL (ML)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jeffrey Alan Klein, MD
Aortic Aneurysm and Dissection
A Prospective Study of Discomfort Symptoms in Patients With Aortic Disease After Endovascular Intervention
The incidence and severity of post-procedural discomfort were evaluated in patients undergoing endovascular repair for aortic disease across six symptom-related dimensions: immobilization-related issues, puncture site discomfort…
- Trial name
- NCT07114185
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Gastrointestinal Discomfort
The Effect of Natural Carbonated Mineral Water Consumption on Gastrointestinal Transit and Gut Microbiota - A Randomized Controlled Trial
Gastrointestinal discomfort is a common condition associated with aging, low levels of physical activity, and reduced intake of fibre, water, and magnesium.
- Trial name
- NCT05375487
- Testing
- Natural Carbonated Mineral Water, Low Mineral Water
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Chronic Rhinitis, Chronic Pharyngitis
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Chronic Nasopharyngitis
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of nasopharyngeal administration of 13.6% high-concentration 35 kDa hyaluronan (HA35) care gel in subjects with chronic…
- Conditions
- Chronic Rhinitis, Chronic Pharyngitis, Nasopharyngitis, Posterior Pharyngeal Inflammation
- Trial name
- HA35 (NCT07568548)
- Testing
- 13.6% High-Concentration 35 kDa Hyaluronan (HA35) Nasopharyngeal Care Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Pain Due to Certain Specified Procedures
Novel Cervical Retraction Device
This study will test a suction-based method of engaging the cervix. Bioceptive has developed a device that more gently and atraumatically attaches to the cervix with no bleeding.
- Trial name
- NCT02283463
- Testing
- Intrauterine device (IUD) insertion, Endometrial biopsy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bioceptive
Patients Undergoing Diagnostic EGD
Reduce Patient Discomfort With Water Exchange Method During Upper Endoscopy
The aim of the study was to evaluate the application of water exchange method to upper endoscopy. We hypothesize that water exchange during upper endoscopy could reduce patient discomfort.
- Trial name
- NCT04502485
- Testing
- Gastric water exchange, traditional air insufflation
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Yu-Hsi hsieh
Abdominal Pain, Abdominal Discomfort
Pilot Study Studying Physiological Effects of Probiotic Pills in Patients With Abdominal Pain/Discomfort and Bloating
We are conducting a study to learn if probiotics, which are live bacteria found in food like yogurt and cheese, will improve symptoms of abdominal pain.
- Conditions
- Abdominal Pain, Abdominal Discomfort, Bloating, Functional Bowel Disorders
- Trial name
- NCT01064661
- Testing
- Single probiotic arm of L-NCFM alone, Blend probiotic arm of L-NCFM and B-LBi07
- Volunteers
- 22 people
- Sponsor
- University of North Carolina, Chapel Hill
Catheter-Related Bladder Discomfort, Urinary Catheter
Efficacy of Reduction of the Balloon Volume for Prevention of Postoperative Catheter-related Bladder Discomfort in Patients Undergoing Non-lower Urinary Tract Surgery
CRBD is related to different degrees of irritation caused by the volume of the balloon in the urinary catheter, and when CRBD occurs, it may cause severe postoperative pain and trauma by self-removal of the catheter, further…
- Trial name
- NCT06038448
- Testing
- Urinary catheter balloon size
- Volunteers
- 120 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Injection Site Discomfort
A Controlled Study on Pain Management With Injection of Botulinum Toxin for Glabellar Line Correction
This is an open-label, single-center, randomized, split-face, controlled study to assess the effect of comfort intervention on pain during treatment injection compared against non-comfort intervention.
- Trial name
- NCT06161246
- Testing
- Vibrating Beauty Bar
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Dyspnea
Inhaled Ondansetron & Dyspnea
"Dyspnea" refers to the awareness of breathing discomfort that is typically experienced during exercise in health and disease. In various participant populations, dyspnea is a predictor of disability and death; and contributes to…
- Trial name
- NCT01851993
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Peripheral Arterial Disease
Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities
The goal of this study is to evaluate whether supervised treadmill exercise combined with ranolazine 1000 mg twice daily provides an incremental benefit in absolute walking distance over supervised exercise alone in patients with…
- Trial name
- STERILE (NCT00914316)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Corewell Health East
Anesthesia, Local, Pain Control
Should Maxillary Buccal Infiltration Anesthesia be Given in a Closed Mouth Technique?
To study the patients' and dentists' perception of receiving/ administering maxillary buccal infiltration anesthesia using an open or closed mouth techniques
- Trial name
- NCT03921190
- Testing
- Local anesthesia
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Catheter Related Complication
Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery
The investigators aimed to compare the effects of tramadol and dexmedetomidine, which are commonly used in anesthesia, on preventing catheter-related bladder discomfort.
- Trial name
- NCT04314050
- Testing
- Tramadol, Dexmedetomidine, control
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ankara Diskapi Training and Research Hospital
Bladder Pain and Discomfort, Urinary Urgency and Frequency
Sensory Sensitivity and Urinary Symptoms in the Female Population
Bladder pain and discomfort, as well as urinary urgency and frequency, are bothersome symptoms seen frequently in the general population.
- Conditions
- Bladder Pain and Discomfort, Urinary Urgency and Frequency, Bothersome Symptoms
- Trial name
- NCT01978002
- Testing
- Pain sensitivity testing, Urodynamic testing
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypermobility, Joint, Hypermobility Syndrome
Exercise in Patients With Hypermobile Joints and Knee Pain
Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving…
- Conditions
- Hypermobility, Joint, Hypermobility Syndrome, Knee Discomfort
- Trial name
- HIPEr-Knee (NCT06277401)
- Testing
- Neuromuscular training for the knee, High-load strength training for the knee
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Southern Denmark
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Catheter Related Bladder Discomfort
Paracetamol for Catheter Related Bladder Discomfort
The insertion of an urinary catheter in a patient undergoing a surgical procedure, especially in urinary interventions, may lead to catheter-related bladder discomfort with varying degrees of severity during the postoperative…
- Trial name
- NCT01652183
- Testing
- intravenous paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Pinar Ergenoglu
Chronic Dizziness
Study to Assess the Efficacy and Safety of SpotOn Specs™ for the Treatment of Chronic Dizziness
The diagnosis and management of acute vertigo and dizziness is most of the time an easy task for the general practitioner. However, following an acute vestibular disorder and very often with no any overt cause, a considerable…
- Trial name
- NCT01460121
- Testing
- SpotOn's corrective elements for dizziness
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Meir Medical Center
Epiphora, Dacryostenosis
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT05663684
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans