Clinical trials: Disc Herniation, Lumbar
Lumbar Disc Herniation, Postoperative Pain
Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine Surgery
This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block.
- Trial name
- TLIP-QIP (NCT07750418)
- Testing
- Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine, Quadratus Lumborum-Iliac Plane (QIP) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Vezirköprü State Hospital
Degenerative Disc Disease, DDD
Biologic Injection For Adults With Lumbar Disc Herniation
The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.
- Conditions
- Degenerative Disc Disease, DDD, Degenerative Disc Disease Lumbar, Degenerative Disc Disease, Lumbar
- Trial name
- BMAC (NCT07386548)
- Testing
- Bone Marrow Aspirate Concentrate (BMAC)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Weill Medical College of Cornell University
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University
Lumbar Disc Herniation, Chronic Low Back Pain
High-Intensity Laser Therapy Versus Transforaminal Epidural Steroid Injection in Chronic Lumbar Disc Herniation-Related Low Back and Radicular Pain
This prospective, randomized, single-blinded, controlled clinical trial aims to compare the effectiveness of high-intensity laser therapy and fluoroscopy-guided transforaminal epidural steroid injection in patients with chronic…
- Conditions
- Lumbar Disc Herniation, Chronic Low Back Pain, Radicular Pain, Lumbar Radiculopathy
- Trial name
- NCT07688915
- Testing
- High-Intensity Laser Therapy, Transforaminal Epidural Steroid Injections
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Disc Herniation, Mindfulness Meditation
Mindfulness-based Psychoeducation in Patients With Lumbar Disc Herniation
This study aimed to investigate the effect of mindfulness-based psychoeducation on mindfulness, automatic thoughts, and pain beliefs in patients with lumbar disc herniation.
- Trial name
- MBPE (NCT07683884)
- Testing
- Experimental Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Giresun University
Lumbar Disc Herniation, Emergence Agitation
Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery
In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under…
- Conditions
- Lumbar Disc Herniation, Emergence Agitation, Magnesium Sulfate
- Trial name
- NCT07139847
- Testing
- Magnesium Sulfate Infusion, 0.9% Saline Infusion
- Volunteers
- 70 people
- Sponsor
- Ondokuz Mayıs University
Lumbar Disc Herniation Surgery, Disc Herniation
Return to Activity After Surgery for Lumbar Disc Herniation
RCT investigating postoperative activity restriction after lumbar discectomy in patients treated with annular closure.
- Trial name
- NCT07667348
- Testing
- Postoperative therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Intrinsic Therapeutics
Lumbar Disc Degeneration, Lumbar Disc Disease
Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement
Lumbosciatica is a very prevalent pathology. When conservative treatments fail, surgery should be considered. The traditional surgical treatment is lumbar arthrodesis.
- Conditions
- Lumbar Disc Degeneration, Lumbar Disc Disease, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06989632
- Testing
- Total lumbar disc prosthesis (Baguera®L, Spineart, Switzerland)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- University of Valencia
Lumbar Disc Herniation, Low Back Pain
Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery
This randomized controlled trial aims to compare the effectiveness of early mobilization alone versus early mobilization combined with electrical stimulation on functional recovery following lumbar disc herniation surgery.
- Conditions
- Lumbar Disc Herniation, Low Back Pain, Postoperative Rehabilitation
- Trial name
- EMES-LDH (NCT07575477)
- Testing
- Early Mobilization Program, Electrical Stimulation (NMES/TENS)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Low Back Pain, Physical Therapy
Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings
Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the…
- Conditions
- Low Back Pain, Physical Therapy, Lumbar Degenerative Disc Disease, Lumbar Disc Herniation
- Trial name
- NCT07648927
- Testing
- Standard Physical Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bahçeşehir University
Lumbar Degenerative Disease, Lumbar Radiculopathy
Comparison of Clinical Effectiveness of Full Endoscopic Lumbar Discectomy (FELD) and Microdiscectomy (MD) in Patients With Lumbar Disc Herniation
The goal of this clinical trial is to compare the clinical effectiveness of Full Endoscopic Lumbar Discectomy (FELD) and Microdiscectomy (MD) in patients aged 18-85 with single-level lumbar disc herniation who have not undergone…
- Conditions
- Lumbar Degenerative Disease, Lumbar Radiculopathy, Sciatic Leg Pain, Sciatic Nerve Compression
- Trial name
- NCT06615518
- Testing
- FELD (Full-Endoscopic Lumbar Discectomy), comprising IELD and TELD as anatomical subgroups, Microdiscectomy
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- University of Opole
Lumbar Spine Stenosis, Lumbar Disc Herniation
Dynamic Compliance-Guided Ventilation in Lumbar Surgery
Postoperative pulmonary complications are a frequent cause of morbidity following lumbar stabilization surgery. Conventional ventilation strategies may not adequately reflect intraoperative changes in respiratory mechanics…
- Conditions
- Lumbar Spine Stenosis, Lumbar Disc Herniation, Ventilator-Induced Lung Injury, Postoperative Complications
- Trial name
- NCT07349719
- Testing
- Dynamic Compliance Guided Ventilation, Standard Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara City Hospital Bilkent
Lumbar Disc Herniation
Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
- Trial name
- Intra-Op (NCT04182997)
- Testing
- Dexamethasone, saline 0.9%
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Missouri-Columbia
Lumbar Disc Herniation Surgery, Mechanical Ventilation
Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery
This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc…
- Trial name
- NCT07614555
- Testing
- FCV Group, VCV Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Lumbar Disc Herniation With Radiculopathy, Sciatica
FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation
The FINDISC trial studies whether common back operation, microdiscectomy, is effective and safe for treating sciatica caused by a lumbar disc herniation.
- Trial name
- FINDISC-Pain (NCT07418944)
- Testing
- Microdiscectomy
- Where
- Finland
- Volunteers
- 122 people
- Sponsor
- Helsinki University Central Hospital
Sciatica, Lumbar Disc Herniation
Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial
The goal of this clinical trial is to learn if electroacupuncture can improve sleep in people with chronic sciatica caused by lumbar disc herniation. It will also assess the safety of this treatment.
- Conditions
- Sciatica, Lumbar Disc Herniation, Insomnia
- Trial name
- NCT07576348
- Testing
- Electroacupuncture
- Volunteers
- 114 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Radicular Pain, Lumbar Surgery
Return to Work After Lumbar Surgery: a Nationwide Survey of Spinal Surgeons' Practices
This national cross-sectional survey investigates the current practices and perceptions of Belgian spinal surgeons regarding return to work (RTW) after lumbar surgery for radicular pain.
- Conditions
- Radicular Pain, Lumbar Surgery, Radicular Pain Related to Lumbosacral Disc Disease, Fusion of Spine, Lumbar Region
- Trial name
- NCT07193758
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Radiculopathy, Lumbar Disc Herniation
Treatment Response to TFESI and DRG Pulsed RF in Lumbar Spinal Stenosis and Disc Herniation
Lumbar radiculopathy caused by conditions such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS) can lead to chronic pain and reduced quality of life.
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Lumbar Spinal Stenosis (LSS)
- Trial name
- NCT07509580
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University