Sciatic Leg PainNCT07721220
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
A study testing Sciatic Slider, Sciatic Tensioner and Mechanically loaded neurodynamic sciatic floss in people with Sciatic Leg Pain and Hamstring Muscle Tightness, run by High Point University at 1 site in United States.
Trial summary
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain
- What is being tested?
- Sciatic Slider, Sciatic Tensioner and Mechanically loaded neurodynamic sciatic floss
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jun 2026to Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants must be between 18 and 30 years of age.
- Must be able to read, understand, and provide informed consent, in English.
- Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).
- Medically stable with no known contraindications to physical exertion.
- Cleared for participation in strength or maximal-effort isometric testing.
- Be able to perform lower extremity isometric testing without pain that limits maximal effort.
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- Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.
- No medical condition that significantly alters lower extremity neuromuscular performance.
- No history of lower extremity surgery in the past 12 months.
Who cannot join
- Individuals younger than 18 or older than 30.
- Acute lower extremity injury in the last 12 weeks.
- Lower extremity surgery within the last 12 months.
- Pain in either lower extremity that would limit maximal physical exertion.
- History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.
- Use of medications that significantly impact neuromuscular performance, strength or fatigue.
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- No supplementation that affects neuromuscular performance, strength, or fatigue.
- Unable to read and understand English.
- Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
High Point University
High Point, North Carolina, 27268
Dr. Tommy Wyatt, DPT, 856-381-6652, twyatt2@highpoint.edu
Tommy Wyatt, DPT
About this study
Official title: Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength, Hamstring Injuries, Hamstring Injury Prevention
- Being tested
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss, Elastic Resistance Band
- Keywords
- hamstring, sciatic nerve, athlete
- Medical subject headings
- Intervertebral Disc Displacement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sciatic SliderOther
Mobility of a nerve, by placing tension on one end of the nerve and slacking (removing) tension off the other side of the nerve, through a full range of motion.
Sciatic TensionerOther
Loading the nerve, by placing tension on both ends of the nerve, isometrically at end range of motion.
Mechanically loaded neurodynamic sciatic flossOther
Placing tension on one end of the nerve while taking the tension off the other end, under external load of an elastic resistance band.
Elastic Resistance BandDevice
Elastic resistance band was used to provide submaximal resistance during the mechanically loaded neurodynamic intervention.
| Study group | Role | What they receive |
|---|---|---|
| Sliders | Active comparator | Manually applying slider technique of neurodynamics. Receives: Other: Sciatic Slider |
| Tensioners | Active comparator | Manually applied tensioner, neurodynamic technique Receives: Other: Sciatic Tensioner |
| Mechanically Loaded Neurodynamics | Experimental | Externally loaded neurodynamic intervention in the slider technique. Receives: Other: Mechanically loaded neurodynamic sciatic floss; Device: Elastic Resistance Band |
What is being measured
The primary outcome is the main question the study is designed to answer.
Isometric Strength
Isometric strength of the hamstrings in knee flexion.
Measured: From initial strength and endurance test, to the post intervention strength and endurance test, assessed during a single study visit, assessed up to 30 minutes.
Secondary outcomes (1)
Endurance Ratio (isokinetic)
Endurance ratio of knee flexion, measured isokinetically.
Measured: From initial endurance test to post intervention endurance test, during a single study visit, assessed up to 30 minutes.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jul 2026
- Study start15 Jun 2026
- Primary completionJul 2026 (estimated)
- Study completionJul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sciatic Leg PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 45 participants (estimated)
Sponsor and investigators
- Lead sponsor
- High Point University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tommy Wyatt, High Point University
- Investigators
- Tommy Wyatt, DPT, Principal investigator, High PointUniversity
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07721220
- Sponsor's protocol ID
- IRB-FY2026-110
- Status last verified
- Jul 2026
- First submitted
- 16 Jul 2026
- Last updated
- 22 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The raw pre and post isometric and isokinetic endurance ratio data for each participant will be shared. Along with the intervention leg, testing order, intervention provided, level of athletic participation, primary sport activity, age, sex.
Study at a glance
From the registry record, last updated by the sponsor on 22 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial
- ClinicalTrials.gov ID
- NCT07721220
- Acronym / sponsor ID
- IRB-FY2026-110
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength, Hamstring Injuries, Hamstring Injury Prevention
- Keywords
- hamstring, sciatic nerve, athlete
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 45 participants (estimated)
- Lead sponsor
- High Point UniversityUniversity, hospital or other
- Study start
- 15 Jun 2026 (actual)
- Primary completion
- Jul 2026 (estimated)
- Study completion
- Jul 2026 (estimated)
- First posted
- 22 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Sliders | Active comparator | Other: Sciatic SliderManually applying slider technique of neurodynamics. |
| Tensioners | Active comparator | Other: Sciatic TensionerManually applied tensioner, neurodynamic technique |
| Mechanically Loaded Neurodynamics | Experimental | Other: Mechanically loaded neurodynamic sciatic floss, Device: Elastic Resistance BandExternally loaded neurodynamic intervention in the slider technique. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (9 listed)
- Participants must be between 18 and 30 years of age.
- Must be able to read, understand, and provide informed consent, in English.
- Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).
- Medically stable with no known contraindications to physical exertion.
- Cleared for participation in strength or maximal-effort isometric testing.
Key exclusion criteria (9 listed)
- Individuals younger than 18 or older than 30.
- Acute lower extremity injury in the last 12 weeks.
- Lower extremity surgery within the last 12 months.
- Pain in either lower extremity that would limit maximal physical exertion.
- History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sciatic SliderMobility of a nerve, by placing tension on one end of the nerve and slacking (removing) tension off the other side of the nerve, through a full range of motion. | Other | Sliders |
| Sciatic TensionerLoading the nerve, by placing tension on both ends of the nerve, isometrically at end range of motion. | Other | Tensioners |
| Mechanically loaded neurodynamic sciatic flossPlacing tension on one end of the nerve while taking the tension off the other end, under external load of an elastic resistance band. | Other | Mechanically Loaded Neurodynamics |
| Elastic Resistance BandElastic resistance band was used to provide submaximal resistance during the mechanically loaded neurodynamic intervention. | Device | Mechanically Loaded Neurodynamics |
Primary outcome
Isometric Strength
Time frame: From initial strength and endurance test, to the post intervention strength and endurance test, assessed during a single study visit, assessed up to 30 minutes.
Isometric strength of the hamstrings in knee flexion.
1 secondary outcome
Endurance Ratio (isokinetic)
Time frame: From initial endurance test to post intervention endurance test, during a single study visit, assessed up to 30 minutes.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jul 2026.
- Individual participant dataSharing planned: Yes. The raw pre and post isometric and isokinetic endurance ratio data for each participant will be shared. Along with the intervention leg, testing order, intervention provided, level of athletic participation, primary sport activity, age, sex.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Tommy Wyatt, DPT principal investigator
High PointUniversity
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sciatic Slider, Sciatic Tensioner and Mechanically loaded neurodynamic sciatic floss in people with Sciatic Leg Pain and Hamstring Muscle Tightness, run by High Point University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dr. Tommy Wyat, DPT (856-381-6652, twyatt2@highpoint.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Isometric Strength (time frame: From initial strength and endurance test, to the post intervention strength and endurance test, assessed during a single study visit, assessed up to 30 minutes.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jul 2026.