Clinical trials: Diminished Ovarian Reserve, active
Diminished Ovarian Reserve, Female Infertility
Hippo-Related Competing Endogenous RNA (ceRNA) Network Dysregulation and In Vitro Fertilization (IVF) Outcomes in Women With Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) is an important cause of female infertility and is associated with poor ovarian response and lower pregnancy rates during In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, Female Infertility, In Vitro Fertilization
- Trial name
- DOR-HIPPO-IVF (NCT07658846)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Diminished Ovarian Reserve
DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT
One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed.
- Trial name
- DPOS (NCT05847283)
- Testing
- Dydrogesterone priming ovarian stiumulation protocol, GnRH antagonist protocol
- Where
- 2 sites in Vietnam
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Tam Anh TP. Ho Chi Minh General Hospital
Diminished Ovarian Reserve
Characterization of Gut and Tongue Coating Microbiota in Patients With Diminished Ovarian Reserve
The goal of this observational study is to investigate the distinct tongue manifestation characteristics in patients with diminished ovarian reserve (DOR) compared to healthy individuals, and to clarify the features of tongue…
- Trial name
- CGTCMPDOR (NCT07124260)
- Testing
- gut microbiota, tongue coating microbiota, tongue picture
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University
Diminished Ovarian Reserve (DOR)
Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Diminished Ovarian Reserve
A multi-center, prospective, randomised controlled clinical trial (1:1 treatment ratio), designed to investigate the efficacy and safety of autologous SVF in improving the pregnancy outcome of infertile patients with DOR.
- Trial name
- aSVF-DOR (NCT07901218)
- Testing
- Lower abdominal liposuction and preparation of SVF, Ovarian injection, Conventional ART treatment
- Where
- 4 sites in China
- Volunteers
- 260 people
- Sponsor
- Peking University Third Hospital
Diminished Ovarian Reserve (DOR)
Clinical and Metabolomics Studies on the Improvement of Ovarian Reserve by Acupoint Photodynamic Therapy and Traditional Chinese Medicine Treatment
Diminished Ovarian Reserve (DOR) refers to a reduction in the number of recruitable follicles in the ovaries and/or a decline in oocyte quality. Current research on its etiology and treatment remains unsatisfactory.
- Trial name
- NCT07376824
- Testing
- Traditional Chinese Medicine, Photodynamic therapy (PDT)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
ICS
Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction.
- Trial name
- NCT07318974
- Testing
- Melatonin capsule
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Benha University
Infertility, Female, Ovarian Reserve
hCG Priming in Women With Diminished Ovarian Reserve
The aim of this randomized controlled trial is to further examine the possible effects of low dose human chorionic gonadotropin (hCG) priming for eight weeks in women with diminished ovarian reserve (DOR) undergoing in vitro…
- Conditions
- Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)
- Trial name
- NCT07108621
- Testing
- Choriongonadotropin alfa (hCG)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Kristine Loessl
Infertility, Female
Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation
The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro…
- Trial name
- NCT06701071
- Testing
- Clomiphene Citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Diminished Ovarian Reserve
A Randomized Controlled Trial of Combined Bu Shen Yi Qi Decoction and Dehydroepiandrosterone (DHEA) for the Treatment of Ovarian Function Decline
The purpose of this clinical trial is to evaluate the efficacy and safety of Bushen Yiqi formula combined with dehydroepiandrosterone (DHEA) in the treatment of women with diminished ovarian reserve (DOR).
- Trial name
- NCT07535983
- Testing
- Bushen formula combined with dehydroepiandrosterone
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology
Impact of Day 2 Versus Day 3 Fresh Embryo Transfer on Live Birth Rate in Poor-Prognosis Patients
This study aimed to compare the efficacy (live birth rate) of fresh embryo transfer on Day 2 versus Day 3 in POSEIDON Group 4 patients, and to determine the optimal timing of embryo transfer for this population.
- Conditions
- POSEIDON Category 4, Low Prognosis in Assisted Reproductive Technology, Female Infertility Due to Diminished Ovarian Reserve
- Trial name
- NCT07533695
- Testing
- Day 2 Fresh Embryo Transfer
- Volunteers
- 470 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Diminished Ovarian Reserve
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.
- Trial name
- NCT06426355
- Testing
- NMN
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Decreased Ovarian Reserve
Real-world Evaluation of Qingxin Zishen Decoction on Ovarian Reserve Function Clinical Efficacy in Patients With Decreased
A prospective cohort study evaluated the clinical efficacy of Qingxin Zishen Decoction
- Trial name
- NCT06332742
- Where
- China
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Yun Chen
Diminished Ovarian Reserve
Ovarian PRP for Diminished Ovarian Reserve
This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished…
- Trial name
- oPRP (NCT05790655)
- Testing
- oPRP
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Infertility, Female, Miscarriage
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.
- Conditions
- Infertility, Female, Miscarriage, Miscarriage, Recurrent, IVF
- Trial name
- NCT05969574
- Testing
- Transvaginal ultrasound, Blood test AMH
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 2,059 people
- Sponsor
- ART Fertility Clinics LLC
Diminished Ovarian Reserve, IVF
Study of G-CSF for DOR in Patients Undergoing IVF
Diminished ovarian reserve (DOR) is defined by reduced follicle counts in women, associated with decreased fertility and lower success rates with In Vitro Fertilization (IVF).
- Conditions
- Diminished Ovarian Reserve, IVF, G-CSF, Granulocyte Colony Stimulating Factor
- Trial name
- NCT07871825
- Testing
- Neupogen 300 μg subcutaneous injection, Subcutaneous injections of a saline solution
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Center for Human Reproduction
Diminished Ovarian Reserve (DOR), Infertility
Clinical Evaluation of Integrated Chinese-Western Medicine for Infertility With DOR Patients in Women Achieving Natural Pregnancy
This study aims to evaluate the superiority of an integrated traditional Chinese and Western medicine regimen ("Xiehe DOR Bushen Tongzhi Formula" + ovulation induction therapy with ovulation monitoring and timed intercourse)…
- Trial name
- NCT07296614
- Testing
- Western Medicine, Traditional Chinese Medicine
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Peking Union Medical College Hospital
Diminished Ovarian Reserve (DOR)
Guishen Yijing Granules for Diminished Ovarian Reserve With Kidney Deficiency Syndrome: A Randomized Controlled Trial
This study is a multicenter, stratified block-randomized, double-blind, double-dummy clinical trial designed to evaluate the efficacy and safety of Guishen Yijing Granules in patients with diminished ovarian reserve (DOR) and…
- Trial name
- NCT07841548
- Testing
- Guishen Yijing Granules, Coenzyme Q10 (drug)
- Volunteers
- 120 people
- Sponsor
- Shi Yun
Infertility, Obesity
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype.
- Conditions
- Infertility, Obesity, Diminished Ovarian Reserve (DOR), Diminished Ovarian Reserve
- Trial name
- NCT06414096
- Testing
- Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi)
Safety and Efficacy of Autologous Adipose-Derived Regenerative Cells (ADRCs) Injection for Improving Diminished Ovarian Reserve
Diminished Ovarian Reserve (DOR) poses significant challenges to fertility and hormonal health, with limited effective treatments.
- Conditions
- Diminished Ovarian Reserve (DOR), Primary Ovarian Insufficiency (Poi), Ovarian Failure, Premature
- Trial name
- ARISE-01 (NCT07117682)
- Testing
- Autologous Adipose-Derived Regenerative Cells (ADRCs) Intraovarian Injection
- Volunteers
- 25 people
- Sponsor
- Cytori Therapeutics