Clinical trials: Dilation
Peripheral Artery Disease
BIOTRONIK Dynetic-35 Stent for the Treatment of Peripheral Iliac Lesions
BIOTRONIK cobalt chromium balloon-expandable Dynetic-35 stent in association with Passeo-35 Xeo peripheral dilation catheter for the treatment of peripheral iliac lesions
- Trial name
- BIONETIC-I (NCT04830228)
- Testing
- Ballon expandable stent and PTA
- Where
- 15 sites in Austria, Belgium and 4 more
- Volunteers
- 160 people
- Sponsor
- Biotronik AG
Tricuspid Regurgitation Functional
Early Feasibility Study of the Cardiac Implants Percutaneous Ring Annuloplasty System
An early feasibility study to evaluate the safety and performance of 1) the transcatheter delivery and implantation of the Cardiac Implants (CI) annuloplasty ring and 2) the adjustment of the ring approximately 90 days following…
- Trial name
- NCT04890821
- Testing
- CI Percutaneous Ring Annuloplasty System
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Cardiac Implants LLC
Pregnancy
Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus.
- Trial name
- NCT03315806
- Testing
- Beetroot juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Coronary Artery Disease
Effect of Garlic Tablet Some Indicators Related to Atherosclerosis
The purpose of this study is to determine whether garlic in adjunct to conventional medical treatment is effective in improving carotid intima media thickness (CIMT), Flow mediated dilation (FMD) and plasma lipid profile or…
- Trial name
- NCT01948453
- Testing
- Garlic
- Where
- Iran
- Volunteers
- 56 people
- Sponsor
- Shahid Beheshti University
Cataracts
Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bacterial Load Prior to Cataract Surgery in Patients Treated With a Lidocaine Gel Dilating Formulation Versus Eye Drops: A Randomized Controlled Trial
The eye contains a lens that focuses light. A clouding of the lens is known as a cataract. Cataracts decrease vision. The treatment for cataracts is cataract surgery.
- Trial name
- NCT01898728
- Testing
- topical povidone-iodine after premedication with topical liquid eye drops, topical povidone-iodine after premedication with topical gel
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Crohn Disease (CD), Intestinal Stricture
Endoscopic Stricturotomy Versus Balloon Dilation for Small Bowel Fibrotic Strictures in Crohn's Disease
This multicenter, open-label, randomized controlled trial aims to compare the safety and immediate effectiveness of endoscopic stricturotomy (ES) and endoscopic balloon dilation (EBD) for the treatment of small bowel fibrotic…
- Conditions
- Crohn Disease (CD), Intestinal Stricture, Intestinal Fibrosis
- Trial name
- NCT07833332
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Choledocholithiasis, Choledocholithiasis With Cholecystitis
The Significance of Laparoscopic Transcystic Papilla Vateri Balloon Dilatation in Patients With Choledocholithiasis.
A prospective randomized trial. It is planned to analyze groups of patients with cholecystitis and choledocholithiasis. As part of the study, after signing the consent, the patients will be divided into two groups that have…
- Trial name
- DILAILA (NCT07503964)
- Testing
- Endoscopic retrograde cholangiopancreatography with papillotomy and stone evacuation from common bile duct., Laparoscopic Cholecystectomy., Laparoscopic transcystic balloon dilatation of the papilla Vateri.
- Where
- Latvia
- Volunteers
- 100 people
- Sponsor
- Riga East Clinical University Hospital
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic
Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury
Trial Objectives: This clinical trial aims to explore whether ultrasound - guided urethral balloon dilation can effectively improve the micturition function of patients with urinary retention after spinal cord injury, and to…
- Conditions
- Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic, Urinary Retention
- Trial name
- NCT06978205
- Testing
- Urethral Balloon Dilation, intermittent catheterization, Acupuncture treatment
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Qilu Hospital of Shandong University
Dilated Cardiomyopathy, Heart Failure
PUFAs and Left Ventricular Function in Heart Failure
The purpose of this study is to test the hypothesis that n-3 PUFAs improve left ventricular systolic function in patients with stable chronic HF secondary to nonischemic dilated cardiomyopathy (NICM).
- Trial name
- CS-PUFA-02 (NCT01223703)
- Testing
- n-3 PUFAs
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Università degli Studi di Brescia
PERIPHERAL VASCULAR DISEASE
Study Comparing Two Methods of Expanding Stents Placed in Legs of Diabetics With Peripheral Vascular Disease
Despite recent advances in stent technology and its widespread application in the treatment of peripheral vascular disease (PVD), incidences of partial or complete blockage of stent lumen (in-stent restenosis) due to in growth of…
- Trial name
- COBRA (NCT00827853)
- Testing
- Conventional angioplasty balloon, cryoplasty balloon
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- North Texas Veterans Healthcare System
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Carotid Stenosis, Carotid Artery Diseases
Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III)
The PERFORMANCE III study is a prospective, multicenter single-arm, open label study to evaluate the safety and effectiveness of the Neuroguard IEP® Direct System for the treatment of carotid artery stenosis in subjects at…
- Trial name
- NCT05845710
- Testing
- Neuroguard IEP Direct System
- Where
- 32 sites in United States, France
- Volunteers
- 178 people
- Sponsor
- Contego Medical, Inc.
Cataract Surgery
Evaluation of a Protocol of Pupil Dilation Before Laser-assisted Cataract Surgery
Laser-assisted cataract surgery is an innovative and growing procedure to improve the safety and results of modern cataract surgery.
- Trial name
- MYFLACS (NCT03375996)
- Testing
- cyclopentolate 0.5% eye drops
- Where
- France
- Volunteers
- 60 people
- Sponsor
- CHU de Reims
Non-ischemic Dilated Cardiomyopathy
Cardiac Magnetic Resonance Guidance of Implantable Cardioverter Defibrillator Implantation in Non-ischemic Dilated Cardiomyopathy
Patients with diagnostic CMR images for assessment of LGE/fibrosis and evidence/presence of non-ischaemic myocardial fibrosis/scar will be randomized to the following treatment groups in a 1:1 ratio: ICD group or Optimal HF care…
- Trial name
- CMR-ICD (NCT04558723)
- Testing
- ICD/CRT-D implantation
- Where
- Germany
- Volunteers
- 760 people
- Sponsor
- Prof. Dr. med. Ingo Eitel
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Micro-doses of Physical Activity for COPD
Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than…
- Conditions
- Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction, Vascular Stiffness, Hypertension
- Trial name
- COPD (NCT05553223)
- Testing
- Microdoses of activity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Anorectal Disorder
The Guarding Reflex Anal, Study of the Modulation Function of Rectal Distension
The term Guarding Reflex refers to a progressive, involuntary increase in the external urethral sphincter activity during bladder filling.This is a mechanism of continence, preventing from unwanted urine leakage in situation of…
- Trial name
- NCT04409054
- Testing
- Cough and Valsalva effort
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gérard Amarenco
Duchenne Muscular Dystrophy, Cardiomyopathy, Dilated
Bisoprolol in DMD Early Cardiomyopathy
This study aimed to use cardiac magnetic resonance imaging (CMR) to evaluate the efficacy and safety of bisoprolol therapy for boys with Duchenne muscular dystrophy(DMD) and preserved ejection fraction.
- Trial name
- NCT03779646
- Testing
- Bisoprolol Fumarate
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital