Clinical trials: Diaphragm
Tracheobronchomalacia
The Effect of Bethanechol on Tracheobronchomalacia
The primary aim of this study is to determine if work of breathing estimated using swing Edi will be improved following initiation of bethanechol in infants with tracheobronchomalacia.
- Trial name
- NCT05299008
- Testing
- Bethanechol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Hiatal Hernia
A Prospective Randomised Multi - Center Trial on the Repair of Large Hiatal Hernias: Absorbable Mesh vs. Pledgeted Sutures vs. Sutures Only
A prospective randomised multi - center trial on the repair of large hiatal hernias with sutures versus pledgeted sutures versus absorbable mesh The primary objective of the present trial is to compare the hiatal hernia…
- Trial name
- NCT04591860
- Testing
- Laparoscopic or robot-assisted hiatal closure (sutures only vs. absorbable mesh vs. pledgeted sutures) and fundoplication according to Toupet
- Volunteers
- 165 people
- Sponsor
- Paracelsus Medical University
Healthy
Effects of Blood Gas Perturbations
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
- Trial name
- NCT07701603
- Testing
- Gas perturbation
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Respiratory Diaphragm
Novel vs. Traditional US Diaphragm Scanning
Occasionally, doctors need to be able to see whether the diaphragm - a muscle in the chest that helps control breathing - is moving properly.
- Trial name
- NCT02617394
- Testing
- Diaphragm scanning - traditional method first, Diaphragm scanning - novel method first
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Mechanical Ventilation Weaning
Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation
Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest…
- Trial name
- NCT06203353
- Testing
- diaphragm ultrasound monitoring
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Mongi Slim Hospital
Respiratory Failure, Diaphragm Disease
POCUS and Respiratory Failure Prognosis Based on Diaphragmatic Dysfunction
This study aims to evaluate the use of POCUS to assess diaphragmatic function and its association with clinical outcomes in patients with respiratory failure who are admitted to the emergency department.
- Trial name
- NCT05869045
- Testing
- Diaphragm shortening fraction measurement by point-of-care ultrasound.
- Volunteers
- 432 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Respiratory Disease
Does NIV-NAVA Improve Diaphragmatic Function in Preterm Infants
Non-Invasive Positive Pressure Ventilation (NIPPV) provides un-synchronized positive pressure and considered to be superior to nCPAP in preventing extubation failure.
- Trial name
- NCT05079412
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Mount Sinai Hospital, Canada
Shoulder Pain, Supraspinatus Tendinitis
MINIMUM EFFECTIVE VOLUME OF BUPIVACAİNE FOR ANTERIOR SUPRASCAPULAR NERVE BLOCK
Various local anesthetic volumes are used in the literature for anterior suprascapular nerve block (ASSB). There are different studies between 15 ml and 5 ml.
- Conditions
- Shoulder Pain, Supraspinatus Tendinitis, Bankart Lesions
- Trial name
- NCT05241977
- Testing
- anterior supra scapular nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- V.K.V. American Hospital, Istanbul
Sepsis
Project 4A: Inspiratory Muscle Training and Diaphragm Strength
Investigators will assess the effect of exercise on markers of inflammation and protein catabolism. This research study will further our understanding of how treating Chronic Critical illness (CCI) - related respiratory muscle…
- Trial name
- NCT02367170
- Testing
- Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Chronic Obstructive Pulmonary Disease
Respiratory Muscle Stretching in Chronic Obstructive Pulmonary Disease (COPD)
Objective: The investigators studied the effects of respiratory muscle stretching in an 8-week pulmonary rehabilitation program. Methods: This was a simple-blind parallel controlled trial, conducted an out-patient clinic.
- Trial name
- NCT00935181
- Testing
- respiratory muscle stretching
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Faculdade Evangelica do Parana
Fetal Surgery, Myelomeningocele
Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery
Open maternal-fetal surgery is currently used on fetuses with myelomeningocele (MMC). Fetoscopic or minimal access fetal surgery is also being used to treat fetuses with congenital diaphragmatic hernia (CDH).
- Conditions
- Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia
- Trial name
- NCT03788122
- Testing
- In-depth interview
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Competitive Atheletes of Brazilian Jiu Jitsu
20 Competitive Athletes of Brazilian Jiu Jitsu Where Randomly Assigned in a Myofascial Diaphragm Release Technique or a Sham Technique in Order to Investigate the Immediate Effects of Thoracic Mobility and Chest Expansion
Thoracic injuries, in high level competitive Brazilian jiu jitsu (BJJ) athletes occupied a significant percentage of all musculoskeletal injuries in this population.
- Trial name
- Myofascial Rx (NCT07150039)
- Testing
- Manual therapy intervention (Chaitow's myofascial diaphragm release)
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Evdokia Billis
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Congenital Diaphragmatic Hernia
Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia
This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH).
- Trial name
- INSPIRE-CDH (NCT03094039)
- Testing
- Ventilatory support while attached to the cord, Immediate cord clamping
- Where
- Canada
- Sponsor
- University of Alberta
Respiratory Muscles
Diaphragm Function and Diver Endurance
This project will test the following hypotheses: 1. Training of the inspiratory muscles increases underwater endurance and reduces hypercapnia in divers. 2.
- Trial name
- NCT04679402
- Testing
- Carbon monoxide 200 ppm in air
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Amyotrophic Lateral Sclerosis, Respiratory Insufficiency
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
ALS is is characterized by a progressive degeneration of motor neurons, leading to progressive weakness of muscles, including respiratory muscles, the diaphragm.
- Trial name
- RespiStimALS (NCT01583088)
- Testing
- phenique nerve stimulation NeurX™ (Synapse Biomedical)
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Induced Diaphragm Dysfunction
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing
A randomized clinical trial to investigate the use of the temporary Diaphragm Pacing Therapy System (DPTS) to rehabilitate the diaphragm in mechanically ventilated patients who have failed at least two weaning attempts.
- Trial name
- RESCUE2 (NCT03096639)
- Testing
- Diaphragmatic Pacing Therapy DPTS
- Where
- 21 sites in France, Germany
- Volunteers
- 110 people
- Sponsor
- Lungpacer Medical Inc.
Congenital Diaphragmatic Hernia
Fetal Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia
The purpose of the study is to study the efficacy of fetal endoscopic tracheal occlusion (FETO) in cases of severe congenital diaphragmatic hernia (CDH).
- Trial name
- FETO (NCT05461222)
- Testing
- Balt "Goldballoon"
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yair Blumenfeld
COPD, COPD Exacerbation
Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate the prognostic role of echographic diaphragmatic assessment and vastus lateralis muscle ultrasound (US) in two independent populations of patients hospitalized for exacerbated Chronic…
- Trial name
- EDIFEB (NCT04509128)
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele Roma
Pulmonary Disease, Chronic Obstructive
Measurements of Diaphragmatic Mobility on COPD Patients
To determine whether the COPD impairs the diaphragmatic mobility (DM), and verify improvements after an inpatient pulmonary rehabilitation (PR).
- Trial name
- NCT02838953
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Casa Di Cura Villa Serena SpA