HealthyNCT07701603
Effects of Blood Gas Perturbations
A study testing Gas perturbation in people with Healthy, run by Swiss Federal Institute of Technology.
Trial summary
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Gas perturbation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- No sites listed yet
- Study dates
- 31 Aug 2026to 31 Dec 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- healthy
- non.smoking
- normal lung function
- BMI: 18.5-29.9 kg/m2
- willing to adhere to study rules
Who cannot join
- Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- Any metal or electronics inside of the body
- Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- History of seizures or epilepsy
- Tattoos on the stimulation sites
- Previous enrolment in this study
- For women: Pregnancy, breastfeeding, or intention to become pregnant during the study
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
- Conditions
- Healthy
- Being tested
- Gas perturbation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Gas perturbationOther
Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.
| Study group | Role | What they receive |
|---|---|---|
| Gas perturbations | Experimental | Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h. Receives: Other: Gas perturbation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diaphragm contractility
Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.
Measured: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2026
- Study start31 Aug 2026 (estimated)
- Primary completion31 Dec 2029 (estimated)
- Study completion31 Dec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 16 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Swiss Federal Institute of Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Spengler M. Christina, Prof., Principal investigator, Exercise Physiology Lab, Department of Health Sciences and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07701603
- Sponsor's protocol ID
- REMEX-WP3
- Status last verified
- Jul 2026
- First submitted
- 8 Jul 2026
- Last updated
- 14 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.
- ClinicalTrials.gov ID
- NCT07701603
- Acronym / sponsor ID
- REMEX-WP3
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 16 participants (estimated)
- Lead sponsor
- Swiss Federal Institute of TechnologyUniversity, hospital or other
- Study start
- 31 Aug 2026 (estimated)
- Primary completion
- 31 Dec 2029 (estimated)
- Study completion
- 31 Dec 2029 (estimated)
- First posted
- 14 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Gas perturbations | Experimental | Other: Gas perturbationEach participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- healthy
- non.smoking
- normal lung function
- BMI: 18.5-29.9 kg/m2
- willing to adhere to study rules
Key exclusion criteria (8 listed)
- Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- Any metal or electronics inside of the body
- Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- History of seizures or epilepsy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Gas perturbationParticipants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition. | Other | Gas perturbations |
Primary outcome
Diaphragm contractility
Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec
Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Spengler M. Christina, Prof. principal investigator
Exercise Physiology Lab, Department of Health Sciences and Technology
Questions about this trial
What is this clinical trial studying?
A study testing Gas perturbation in people with Healthy, run by Swiss Federal Institute of Technology.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Christina M. Spengler, Prof. (+41 44 632 5007, christina.spengler@hest.ethz.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diaphragm contractility (time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jul 2026.