Clinical trials: Diagnostic Imaging
Colorectal Cancer
Efficacy and Safety of Regorafenib Maintenance Therapy in Patients With Metastatic Colorectal Cancer (mCRC)
Regorafenib in third-line treatment of metastatic colorectal cancer(mCRC) significantly prolongs the survival of patients, and its advancement has a sensitizing effect on postline chemotherapy and thus improves the prognosis of…
- Trial name
- NCT05818267
- Testing
- Regorafenib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wei Zhang
Neurofeedback, Cognitive Training
Neurofeedback Removal of Emotional Information From Mind
This project will examine whether individuals can be trained, using real-time feedback about brain function during neuroimaging, to effectively remove thoughts from mind by providing them with a sense of what it feels like to…
- Conditions
- Neurofeedback, Cognitive Training, Memory, Short-Term, Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- remtrain (NCT06460207)
- Testing
- fMRI neurofeedback
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Vulvar Cancer
Study of Near-Infrared Imaging With Indocyanine Green for Detection of Sentinel Lymph Nodes in People With Vulvar Cancer
The purpose of this study is to compare two types of imaging for sentinel lymph node (SLN) mapping in people with early-stage vulvar cancer.
- Trial name
- NCT06127836
- Testing
- ICG guided sentinel lymph node biopsy
- Where
- 8 sites in United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obsessive-Compulsive Disorder, OCD
Neurofeedback for Treatment-resistant Obsessive-compulsive Disorder (OCD)
The aim of this study is to teach participants with a OCD diagnosis and treatment-resistance how to decrease the response from a brain region involved in the disease by using a technique called neurofeedback.
- Trial name
- NCT03956771
- Testing
- Real neurofeedback
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Pedro Morgado
Sickle Cell Disease, Cerebral Stroke
Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
The purpose of the study protocol is to identify imaging biomarkers for brain tissue under high metabolic stress at risk for permanent injury.
- Trial name
- HDDOT CVR (NCT07776444)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Solid Malignancy, Lymphoma
A Phase I Study: PET Imaging of Cancer Patients Using [18F] 4-L-Fluoroglutamine (2S,4R)
This is a Phase I study. This study is the first time that a new experimental drug called 18FFluoroglutamine, or F-Glutamine, is being used in people.
- Trial name
- NCT01697930
- Testing
- [18F] 4-L-Fluoroglutamine (2S,4R)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Aortic Valve Insufficiency, Aortic Stenosis
Three Dimensional Imaging and Wireless Technologies to Enhance Medical Care in Space
NASA has outlined the most urgent threats to life and health in manned spaceflight. One of the threats is the risk of trauma and acute medical problems.
- Trial name
- NCT00598767
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Colon Cancer, Lung Cancer
A Pilot, Open-label Study of 18F-Fluciclatide PET/CT Imaging in the Evaluation of Anti-angiogenic Therapy in Solid Tumors
Background: Fluciclatide is a small cyclic peptide containing the RGD tri-peptide, which preferentially binds with high affinity to alpha(v)beta(3) integrins, which are up-regulated in and may regulate angiogenesis.
- Conditions
- Colon Cancer, Lung Cancer, Cervical Cancer, Renal Cell Carcinoma
- Trial name
- NCT01176500
- Testing
- (18)Fluciclatide
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Pregnancy, Obstetric Labor
Analysis of Contemporary Labor Patterns Measured Via Transperineal Ultrasonography
Primary aim of this study is to analyse contemporary labor patterns by measuring rate of dilatation and head descent via transperineal ultrasonography.
- Trial name
- NCT02393144
- Testing
- Transperineal ultrasonography, General Electric Healthcare Voluson Ultrasound System, Cardiotocography, Bionet FC1400 Fetal Monitor, Amniotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ankara University
Bronchopulmonary Dysplasia, Encephalomalacia
Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants
The purpose of this study is to determine whether treatment of very preterm infants at high-risk for lung and brain injury with low dose hydrocortisone results in improved pulmonary and neurologic outcomes.
- Conditions
- Bronchopulmonary Dysplasia, Encephalomalacia, Premature Birth
- Trial name
- NCT00167544
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Nationwide Children's Hospital
Multimoda Lultasound, Thyroid Cancer
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
The goal of this clinical trial is to explore the value of a multimodal ultrasound model based on Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography and grayscale ultrasound in the differential diagnosis of benign…
- Conditions
- Multimoda Lultasound, Thyroid Cancer, Microvascular Classification
- Trial name
- NCT06530771
- Testing
- ultrasound
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Head and Neck Neoplasms
The Translational Research Image-Guided Operating Room (TRIGORA): Intraoperative 3D Imaging for Head & Neck Surgical Patients
Head and neck cancer surgery presents the challenge of tumour resection in close proximity to critical structures such as the carotid arteries and optic nerves.
- Trial name
- TRIGORA (NCT03345719)
- Testing
- 3D Cone-Beam Imaging
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Voice Disorders
Brain Mapping of Voice Control
Some voice disorders are caused by uncontrolled muscle actions that affect the larynx or voice box. The purpose of this study is to understand 1) how the brain controls voice production; 2) how changes in sensation within the…
- Trial name
- NCT00066911
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Head and Neck Squamous Cell Carcinoma
A Comparison of NETSPOT Imaging Versus F-FDG-PET in Head and Neck Cancer Patients
This is a proof-of-concept trial to compare 18F-FDG-PET/CT with NETSPOT (68Ga-DOTA-TATE), a commercially available radiotracer packet that utilizes 68Ga to image SSTR-specific tissue.
- Trial name
- NCT03602911
- Testing
- The isotope 68Ga, NETSPOT and 18F-FDG-PET/CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Non-small Cell Lung Carcinoma
Evaluation of FLT-PET and DWI-MRI in Patients With NSCLC Treated With a Platinum-based Doublet as Preoperative Chemo
The purpose of the study is to qualify, independently, tumor cell proliferation by 3'-Deoxy-3'-[18F]Fluorothymidine (FLT) -Positron Emission Tomography , and cell death by Diffusion Weighted Imaging (DWI) -Magnetic Resonance…
- Trial name
- EVIDENCE (NCT02273271)
- Testing
- 18F-FLT-PET/CT and DWI-MRI
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 31 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
Breast Reconstruction and Body Map : Assessment by Functional MRI (REMASCO)
Breast reconstruction is an integral part of the management of patients with breast cancer and treated by total mastectomy. The aim of breast reconstruction is to get a satisfying aesthetic and functional result (sensitivity) and…
- Trial name
- REMASCO (NCT02553967)
- Testing
- Functional MRI
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Oscar Lambret
The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke
Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging
We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL.
- Trial name
- NCT06289036
- Where
- China
- Volunteers
- 28 people
- Sponsor
- The First Hospital of Hebei Medical University
Fragile X Syndrome
Optical Imaging as a Tool for Monitoring Brain Function in Fragile X Syndrome
The objective of this project is to explore the potential of functional near- infrared spectroscopy (fNIRS) as innovative functional biomarker for clinical trial readiness in Fragile X Syndrome (FXS) that is still without cure.
- Trial name
- NCT06293027
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Covid19, Bronchoscopy
Narrow Band Imaging Bronchoscopy During SARS-CoV2 Infection
Vascular modifications have been described during SARS-CoV2 infection, especially a dilatation of the bronchial arteries. Within the airway wall, small branches of the bronchial arteries cross the muscle layer to develop a…
- Conditions
- Covid19, Bronchoscopy, Narrow-band Imaging
- Trial name
- SARS-CoV2-NBI (NCT04884061)
- Testing
- NBI images and/or videos
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Healthy Volunteers
Healthy Lung Study- Development of 3T MRI Hardware and Software for 3He Gas Imaging of the Lung: Healthy Volunteer Development Study
Healthy volunteers aged 18-75 will undergo hyperpolarized 3-Helium MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
- Trial name
- NCT03169673
- Testing
- Hyperpolarized Helium 3 Magnetic Resonance Imaging
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
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