Clinical trials: Diabetic Neuropathies
Diabetic Neuropathies
A Long-term Study for the Treatment of Painful Diabetic Neuropathy
The purpose of the study is to investigate safety and efficacy of duloxetine for patients with painful diabetic neuropathy at long-term use.
- Trial name
- NCT00641719
- Testing
- Duloxetine hydrochloride
- Where
- 25 sites in Japan
- Volunteers
- 258 people
- Sponsor
- Eli Lilly and Company
Diabetic Foot, Neuropathic Foot Ulcer
Application of S26E for Diabetic Foot Ulcer Healing
A randomized, controlled open-label, parallel group study to examine the effectiveness of a local application of the kalahari melon (Citrullus lanatus) seed oil for the healing of non-infected diabetic foot ulcers.
- Conditions
- Diabetic Foot, Neuropathic Foot Ulcer, Chronic Diabetic Ulcer of Left Foot (Diagnosis), Chronic Diabetic Foot Ulcer of Right Foot
- Trial name
- NCT04186377
- Testing
- Standard-of-care for neuropathic/neuroischemic diabetic foot ulcers, S26E
- Where
- Greece
- Volunteers
- 5 people
- Sponsor
- National and Kapodistrian University of Athens
Neuropathy, Diabetic, Neuropathy;Peripheral
Clinical Efficacy and Human Factors Validation Testing of the Erchonia EVRL for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain
The purpose of this clinical study is to determine the effectiveness of the Erchonia® EVRL™, manufactured by Erchonia Corporation (the Company), in providing prescription home use application for temporary relief of diabetic…
- Conditions
- Neuropathy, Diabetic, Neuropathy;Peripheral, Neuropathy, Painful
- Trial name
- NCT05291975
- Testing
- Erchonia® EVRL™
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- Erchonia Corporation
Diabetic Foot Ulcer
Diabetes Foot Care Clinical Pathway Project - Exciton Technologies Inc
In 2011, the premiers of all Canadian provinces and territories selected diabetes foot care as 1 of 3 significant targets for pan-provincial action.
- Trial name
- DFCCP-Exciton (NCT02990832)
- Testing
- Exciton
- Sponsor
- University of Alberta
Diabetic Foot Ulcer
Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer
The purpose of this study is to determine whether the gentamicin-collagen sponge when combined with standard of daily wound care is safe and effective in treating mildly infected skin ulcers compared to treatment with an oral…
- Trial name
- NCT00593567
- Testing
- gentamicin-collagen sponge, Levofloxacin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Innocoll
Diabetic Foot Ulcer (DFU)
A Study to Evaluate Safety and Efficacy of APO-2 at Three Different Doses in Patients With Diabetic Foot Ulcer
The MARSYAS II study which will be conducted in patients with diabetic foot ulcer (DFU) consists of a Lead-In Phase for safety assessment of multiple doses of the biologic investigational medicinal product (IMP) APO-2 and of a…
- Trial name
- NCT04277598
- Testing
- APO-2
- Where
- 14 sites in Austria, Czechia and 2 more
- Volunteers
- 159 people
- Sponsor
- Aposcience AG
Diabetic Foot Ulcer
Evaluation of Combinational Use of Negative Pressure Wound Therapy (NPWT) for Diabetic Foot Wounds
Singapore has one of the world's highest diabetes-related lower limb amputation rates in the world. Between 2008 - 2017, 4724/5306 (89.0%) of all major amputations and 6656/7227 (92.1%) of all toe/ray amputations performed in…
- Trial name
- NCT06832787
- Testing
- Negative Pressure Wound Therapy, Kerecis, Delayed primary closure with local flap
- Where
- 2 sites in Singapore
- Volunteers
- 75 people
- Sponsor
- Singapore General Hospital
Diabetic Foot Ulcers
Clinical and Cost Effectiveness of Different Dressing Materials in Diabetic Foot Ulcers
The purpose of the study is to evaluate the efficacy and safety of different commonly used dressings for treating diabetic foot ulcers.
- Trial name
- NCT01105884
- Testing
- Normal Saline, Biatin Ag (Foam), Hydrocolloid
- Where
- India
- Sponsor
- M.V. Hospital for Diabetes
Wound Healing
Efficacy Study of a Bioelectric Dressing Used With Negative Pressure Wound Therapy to Treat Diabetic and Pressure Ulcers
The purpose of this study is to determine whether a bioelectric wound dressing, used in conjunction with Negative Pressure Wound Therapy (NPWT), is effective in the treatment of diabetic and pressure ulcers of the foot.
- Trial name
- NCT01022216
- Testing
- Procellera™ Wound Dressing with V.A.C.® Therapy, V.A.C.® Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vomaris Innovations
Diabetic Foot, Diabetic Foot Ulcer
Shear Load In-shoe Plantar Sensing/Strain Analyses and Mapping in Diabetic Foot Ulcers
Stain Analysis Mapping of the Plantar surface (STAMP) is a method designed by the University of Leeds to measure 'in-shoe' strain patterns on the plantar surface of the foot.
- Trial name
- SLIPSTREAM (NCT05687643)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Skin Cancer, Skin Diseases
Multi-modal Quantitative Imaging of the Skin
This clinical trial is about evaluating the suitability of multi-modal imaging technology, which covers virtually the entire body, to evaluate the possibility of screening and early detection of disease.
- Conditions
- Skin Cancer, Skin Diseases, Atopic Dermatitis, Psoriasis
- Trial name
- DermaFlow (NCT06989216)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Diabetic Polyneuropathy
The Effect of Alpha Lipoid Acid and Vitamin B Preparation on Diabetic Polyneuropathy in Type 2 Diabetes Mellitus Patient
To evaluate the efficacy of combination of vitamin B and alpha lipoic acid formulations for the treatment of diabetic polyneuropathy in individuals with type 2 diabetes mellitus.
- Trial name
- NCT06568185
- Testing
- Alpha-Lipoic Acid/Vitamin/Mineral Supplement PolyMVA
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Sains Malaysia
Diabetic Foot
Clinical Trial Evaluating a Hyaluronic Acid Matrix in the Treatment of Chronic Non-healing Diabetic Foot Ulcers (DFUs)
This study is a multi-center, prospective trial designed to evaluate the use of HaM in Wagner grade 1 and 2 DFUs. After screening, subjects are treated with weekly application of HaM and SOC for 8 weeks followed by SOC alone for…
- Trial name
- NCT05198544
- Testing
- Hēlaquis Matrix is a hyaluronic acid matrix (HaM)
- Volunteers
- 15 people
- Sponsor
- SerenaGroup, Inc.
Peripheral Vascular Disease, Diabetic Foot
Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia
Critical limb ischemia is a condition where the blood circulation in the limbs, in most cases the legs, is decreased so that pain and non healing wounds ensue. Mostly, this is a sequel of arteriosclerosis and/or diabetes.
- Conditions
- Peripheral Vascular Disease, Diabetic Foot, Peripheral Arterial Occlusive Disease, Leg Ulcer
- Trial name
- BONMOT (NCT00434616)
- Testing
- Autologous bone marrow cell concentrate transplantation, saline injection
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Franziskus-Krankenhaus
Diabetes Mellitus, Peripheral Neuropathy
Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy.
- Conditions
- Diabetes Mellitus, Peripheral Neuropathy, Small Fibre Neuropathy, Autonomic Neuropathy
- Trial name
- NCT01160887
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Chronic Wounds, Diabetic Foot Ulcer
Subcutaneous Dexpanthenol Administration and Wound Epithelialization
Chronic wounds are wounds that do not heal properly over time and can significantly reduce quality of life. Common types include diabetic foot ulcers, venous leg ulcers, and arterial ulcers.
- Conditions
- Chronic Wounds, Diabetic Foot Ulcer, Venous Leg Ulcers, Arterial Ulcer
- Trial name
- DEXPAN-WOUND (NCT07395674)
- Testing
- Dexpanthenol, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara CANBAY OZDEMIR
Diabetic Foot
Cold Plasma Therapy for Acceleration of Wound Healing in Diabetic Foot
Diabetic foot is a common complication of diabetes mellitus and requires specialized treatment. Wounds are characterized by persistent infection and chronic inflammatory processes, impeding well directed matrix remodelling and…
- Trial name
- NCT04205942
- Testing
- Argon Plasma Jet
- Volunteers
- 65 people
- Sponsor
- Ruhr University of Bochum
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine (SUZ) in participants with pain associated with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT06628908
- Testing
- Suzetrigine, Pregabalin
- Where
- 76 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetic Foot
FeetSee Thermal Images Collection Protocol
The purpose of this study is to collect thermal images of diabetic patients' feet to evaluate the performance of Feetsee - foot monitoring device for periodic evaluation of the temperature over the soles of the feet for signs of…
- Trial name
- NCT05222490
- Testing
- Thermal Camera images acquisition - FeetSee, Thermal Camera images acquisition - Reference
- Where
- Lithuania
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Diabetis JSC
Diabetic Foot Ulcer
Assessment of the Efficacy and Safety of a New Medical Device in the Local Treatment of Diabetic Foot Ulcers
Evaluation of the efficacy and safety of a device with LU3103209 compound versus the same device, free of LU3103209 compound, in the local management of DFUs.
- Trial name
- DISCOVERY (NCT03110796)
- Testing
- Dressing with LU3103209 - Dose 1, Dressing with LU3103209 - Dose 2, Dressing without LU3103209
- Where
- 6 sites in Czechia, France and 4 more
- Volunteers
- 210 people
- Sponsor
- Laboratoires URGO
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