Clinical trials: Diabetic Kidney Disease
Type2 Diabetes Mellitus
Relation of Epicardial Fat and Diabetic Nephropathy in Egyptian Patients
The heart and vessels are surrounded by layers of adipose tissue, which is a complex organ composed of adipocytes, stromal cells, macrophages, and a neuronal network, all nourished by a rich microcirculation.
- Trial name
- NCT03470415
- Volunteers
- 100 people
- Sponsor
- Assiut University
Proteinuria
Effect of Oral Supplementation With Curcumin in Patients With Proteinuric Diabetic Kidney Disease
The purpose of this study is to determine if the oral supplementation with curcumin reduces proteinuria, improves the redox and pro-inflammatory state in patients with chronic kidney disease associated to Diabetes mellitus.
- Trial name
- NCT03019848
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Obesity; Chronic Kidney Disease; Albuminuria
Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney Disease With Albuminuria
This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will evaluate whether starting finerenone together with semaglutide provides an additional reduction in urinary albumin-to-creatinine ratio…
- Trial name
- NCT07849348
- Testing
- Finerenone, Semaglutide
- Volunteers
- 266 people
- Sponsor
- Peking University People's Hospital
Cardiovascular Abnormalities, Chronic Kidney Diseases
Characteristics, Treatment, and Economic Burden of Patients With CVD,CKD or at High Cardiovascular Risk
The heavy disease burden is mainly due to diabetic complications. Diabetes is a major risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD).China has been the largest absolute disease burden of diabetes in…
- Conditions
- Cardiovascular Abnormalities, Chronic Kidney Diseases, Diabetes
- Trial name
- NCT03958760
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- West China Hospital
Diabetic Kidney Disease
The Evaluation of the Drug R3R01 for the Excretion of Protein in the Urine in Patients With Diabetic Kidney Disease.
The goal of this clinical trial is to to investigate whether the drug R3R01 has a beneficial effect on the amount of protein excreted in the urine in adult patients (above 18 years of age) with type 2 diabetes and resulting…
- Trial name
- Kidney ABC (NCT06600412)
- Testing
- R3R01
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- River 3 Renal Corp.
Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2
Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes
This study assesses the efficacy of bardoxolone methyl relative to placebo in delaying progression to end-stage renal disease (ESRD) and cardiovascular deaths in patients with Stage 4 Chronic Kidney Disease (CKD) and type 2…
- Trial name
- BEACON (NCT01351675)
- Testing
- Bardoxolone Methyl: 20 mg
- Volunteers
- 2,185 people
- Sponsor
- Biogen
Diabetic Kidney Disease
Dosimetry of Tc-99m-Tilmanocept
This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common…
- Trial name
- NCT05241522
- Testing
- Tc-99m-Tilmanocept
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Kidney Diseases
China Kidney Patient Trials Network
This is a prospective multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease in China.
- Trial name
- CKPTN (NCT05036850)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- George (Beijing) Clinical Research Co. Ltd.
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Evaluating the Effectiveness of a Smart Screening and Tiered Management Tool for Diabetic Kidney Disease in Primary Care: A Cluster Randomized Trial
This is a cluster-randomized controlled trial aiming to evaluate the effectiveness of an intelligent standardized screening and risk-stratified management tool for diabetic kidney disease (DKD) among adults with type 2 diabetes…
- Trial name
- SMART-DKD (NCT07707518)
- Testing
- Intervention Name Clinical decision support system for diabetic kidney disease (DKD-CDSS), Routine guideline-based diabetes management
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Type 1 Diabetes Mellitus
Efficacy of Islet After Kidney Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468117
- Testing
- Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetic Nephropathy, Endothelial Dysfunction
Flavonoids in the Treatment of Endothelial Dysfunction in Children With Diabetes
Diabetes is the most common metabolic disease of childhood. Vascular disease is a leading complication of diabetes, and attempts to maintain close glycemic control do not prevent the sequelae that claim the lives and quality of…
- Trial name
- flavonoid (NCT01307917)
- Testing
- flavonoids
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Diabetic Kidney Disease (DKD)
ALLOPURINOL AND LISINOPRIL FOR DIABETIC KIDNEY PROTECTION: A COMPARATIVE STUDY IN NORMOURICEMIC TYPE 2 DIABETICS
This randomized controlled trial was conducted at the Department of Medicine and Diabetes of Mayo Hospital/King Edward Medical University, Lahore, over one year.
- Trial name
- NCT07177898
- Testing
- Allopurinol
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Narowal Medical College
Anemia
A Study of Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) for the Treatment of Chronic Renal Anemia in Participants With Diabetic Nephropathy
This single arm, open label study will assess the efficacy, safety and tolerability of methoxy polyethylene glycol-epoetin beta for the treatment of chronic renal anemia in participants with chronic kidney disease (CKD) secondary…
- Trial name
- NCT01191983
- Testing
- Methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 14 sites in India
- Volunteers
- 102 people
- Sponsor
- Hoffmann-La Roche
Inflammation, Chronic Kidney Disease
Role of Prohepcidin in Uremic Patients
The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients.
- Trial name
- NCT01735773
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Diabetic Foot Disease, Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Predictors of Diabetic Foot Outcome in Chronic Kidney Disease Patients
Individuals with diabetic neuropathy and Chronic kidney disease (CKD) are 15 times more likely to have a non-traumatic lower extremity amputation compared to those with DM alone .
- Trial name
- NCT06684886
- Testing
- Ankle Brachial Index
- Volunteers
- 60 people
- Sponsor
- Assiut University
Renal Failure, Chronic
Glucose in Dialysis Water in Non-diabetics
The purposes are 1. to measure the effect of dialysis with glucose on blood pressure, pulse rate, plasma concentration of glucose, plasma concentrations of glucagon, growth hormone, renin, angiotensin II, endothelin and body…
- Trial name
- NCT00439023
- Testing
- dialysis with glucose in dialysis water
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Regional Hospital Holstebro
Diabetic Nephropathies
Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy
This is a multi-center, randomized, parallel study to evaluate effect of exenatide on 24h-UAER in patients with diabetic nephropathy. Screening will be made to select eligible participants before intervention.
- Trial name
- NCT02690883
- Testing
- Exenatide, Lispro
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Diabetic Nephropathy
6-Month Safety And Efficacy Study Of TTP488 In Patients With Type 2 Diabetes And Persistent Albuminuria
Current research indicates that TTP488 may be a viable agent for the treatment of diabetic nephropathy. The purpose of this study is to determine the safety and efficacy of a six-month regimen of daily orally-administered TTP488…
- Trial name
- NCT00287183
- Testing
- PF-04494700 (TTP488)
- Where
- 19 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Pfizer
Type 1 Diabetes
Pancreas Allotransplantation for Diabetic Nephropathy and Mild Chronic REnal fAilure Stage Study
Current medical therapies are not able to prevent progression of established macroproteinuira (i.e. diabetic nephropathy) to end-stage renal failure in type 1 (insulin dependent) diabetic patients.
- Trial name
- PANCREAS (NCT01067950)
- Testing
- Isolated Pancreas Transplant, Intensive Insulin Therapy
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 180 people
- Sponsor
- Nantes University Hospital
End Stage Renal Disease (ESRD), Diabetes
Dianeal, Extraneal, Nutrineal (D-E-N) Versus Dianeal Only in Diabetic Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients
Primary Objective: To demonstrate that use of glucose sparing prescriptions, Dianeal, Extraneal, Nutrineal (D-E-N) versus Dianeal only, in diabetic (Type 1 and Type 2) Continuous Ambulatory Peritoneal Dialysis (CAPD) patients…
- Conditions
- End Stage Renal Disease (ESRD), Diabetes, CAPD
- Trial name
- EDEN (NCT01219959)
- Testing
- Dianeal, Dianeal, Extraneal, Nutrineal
- Where
- 16 sites in Colombia
- Volunteers
- 71 people
- Sponsor
- Vantive Health LLC