Clinical trials: Diabetic Ketoacidosis, active
Diabetic Ketoacidosis
REAMBERIN® 1.5% in Rehydration Therapy of Diabetic Ketoacidosis
A number of scientific papers have been published on the efficacy and safety of adding REAMBERIN® (meglumin sodium succinate), a 1.5% infusion solution, to standard therapy for patients with diabetic ketoacidosis (DKA), which…
- Trial name
- NCT06955416
- Testing
- Reamberin
- Where
- 3 sites in Russia
- Volunteers
- 312 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Diabetes Mellitus, Type 1
The Real-World Control-IQ Glycemic Control and Quality of Life Study in Type 1 Diabetes in France
This post-market surveillance study is primarily designed to demonstrate the ongoing safety of the Control-IQ system, the ongoing performance of glycemic control and quality of life with Control-IQ system use, and the rate of use…
- Trial name
- RECORD-IQ (NCT07211126)
- Testing
- t:slim X2 insulin pump with Control-IQ technology (Control-IQ System)
- Where
- 25 sites in France
- Volunteers
- 350 people
- Sponsor
- Tandem Diabetes Care, Inc.
Diabetic Ketoacidosis, Diabetes Mellitus
Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis
This prospective cohort study aims to evaluate the relationship between admission Leukocyte Glucose Index (LGI) and the severity of diabetic ketoacidosis, as well as the presence of diabetic microvascular complications, among…
- Trial name
- NCT07821814
- Volunteers
- 120 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Diabetic Ketoacidosis
Serum Ferritin and Prognosis of DKA
the aim of this study is to: evaluate the association between serum ferritin levels and the clinical presentation and short-term prognosis of patients with DKA.
- Trial name
- NCT06748365
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Type 1 Diabetes
Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration…
- Trial name
- NCT06922656
- Testing
- Dapagliflozin (DAPA), Pioglitazone 45 mg
- Where
- 3 sites in Kuwait, Qatar and 1 more
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Diabetes Mellitus, Type 1, Diabetes Complications
Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes
Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mortality as their white counterparts.
- Trial name
- NCT06236607
- Testing
- Device specific training, Study clinician/educator visit
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Boston Medical Center
Diabetic Keto-acidosis
Fluid Administration in Ketoacidosis (DRINK)
Management of severe diabetic ketoacidosis is based on insulin therapy, correction of metabolic disorders and fluid resuscitation.
- Trial name
- DRINK (NCT06541535)
- Testing
- Fluid resuscitation with isotonic saline only, Fluid resuscitation with Ringer Lactate
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Type 1 Diabetes, Type 2 Diabetes
Ketone Monitoring Approaches for Diabetic Ketoacidosis Risk Mitigation in People With T1D on Adjunctive SGLT-2 Inhibitors
The purpose of this research is to see how well a special education plan using continuous ketone monitoring (DGK) works to lower the risk of a condition called diabetic ketoacidosis (DKA) in people with type 1 diabetes (T1D)…
- Trial name
- KARMA (NCT07421518)
- Testing
- SGLT-2 inhibitor (Sotagliflozin), Insulin withdrawal test (IWT)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Diabetes Mellitus, Diabetes Mellitus, Type 1
RT-CGM in Young Adults at Risk of DKA
Pilot study to evaluate the effect of real time continuous glucose monitoring (RT-CGM) on young-adults with insulin-treated diabetes, who are defined as high risk due to suboptimal HbA1c (blood glucose control) or a history of…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- YODA (NCT04039763)
- Testing
- Dexcom G6, Self monitoring of blood glucose
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
The BRIGHT Study (Device Name: HALO System)
The purpose of the BRIGHT study is to evaluate safety and performance of the HALO SYSTEM in subjects with diabetes mellitus. The primary objectives of this clinical investigation are 1) the evaluation of sensor's performance by…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Diabetes Mellitus, Ketoacidosis, Diabetic
- Trial name
- NCT07745998
- Testing
- The HALO System
- Volunteers
- 12 people
- Sponsor
- Indigo Diabetes NV
Diabetic Ketoacidosis, Postoperative Care
Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users
The goal of this observational study is to determine the frequency of postoperative euglycemic diabetic ketoacidosis (EDKA) in patients receiving Sodium- Glucose Cotransporter-2 (SGLT-2) inhibitors.
- Trial name
- SGLT-2I (NCT07127406)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Diabetic Ketoacidosis
Perfusion Index for Predicting Diabetic Ketoacidosis Severity in the Emergency Department
This prospective observational cohort study will evaluate whether the perfusion index measured at emergency department admission is associated with the severity of diabetic ketoacidosis in adults.
- Trial name
- NCT07820371
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara Etlik City Hospital
Diabetes (DM), Diabetic Ketoacidosis
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetic ketoacidosis (DKA) is increasingly recognized in adults with "ketone-prone" type 2 diabetes. In many of these patients, the pancreas can still make insulin but becomes temporarily "stunned" during severe, prolonged high…
- Conditions
- Diabetes (DM), Diabetic Ketoacidosis, Ketosis Prone Diabetes, Hyperglycaemia (Diabetic)
- Trial name
- NCT07167693
- Testing
- Arginine hydrochloride, Sodium Chloride 0.9%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David K Carroll
Type 1 Diabetes
Evaluating the Occurrence of DKA in People With Type I Diabetes
This study will evaluate the occurrences of Diabetes-related Ketoacidosis (DKA) in adult and pediatric individuals living with Type I diabetes while managing diabetes with Abbott's Continuous Monitoring Systems.
- Trial name
- NCT07739342
- Testing
- Abbott Continuous Dual Glucose Ketone Monitoring System
- Where
- 7 sites in New Zealand
- Volunteers
- 1,200 people
- Sponsor
- Abbott Diabetes Care
Type 1 Diabetes Mellitus
Dapagliflozin Plus Pioglitazone in T1DM
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120…
- Trial name
- NCT03878459
- Testing
- Pioglitazone 45 mg
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Diabete Type 1, Ketoacidosis, Diabetic
Hemoglobin Levels and Resolution Time of Diabetic Ketoacidosis in Pediatric Patients
This retrospective observational cohort study aims to evaluate the association between hemoglobin levels and the time to resolution of diabetic ketoacidosis (DKA) in pediatric patients.
- Conditions
- Diabete Type 1, Ketoacidosis, Diabetic, Pediatrics, Child
- Trial name
- NCT07377604
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aydin Adnan Menderes University