Clinical trials: Diabetic Foot Ulcer (DFU), active
Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation.
- Trial name
- NCT07877948
- Testing
- Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- BREGO Life Sciences
Diabetic Foot Ulcer (DFU)
Remote Temperature and Visual Monitoring To Help Manage Diabetic Foot Ulcers
This study is a prospective, observational investigation evaluating the effectiveness of Remote ThermoVisual Monitoring (RTVM) in the early detection of diabetic foot ulcers (DFUs) in high-risk populations.
- Trial name
- NCT06782386
- Testing
- OneStep Foot Scanner
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Bluedrop Medical Limited
Diabetic Foot Ulcer, Foot Ulcer Chronic
Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The study is a multicenter, prospective, controlled modified multi-platform trial assessing the efficacy of human placental membrane products and standard of care in the management of nonhealing diabetic foot ulcers and venous…
- Conditions
- Diabetic Foot Ulcer, Foot Ulcer Chronic, DFU, Ulcer Foot
- Trial name
- BIORESCUE (NCT07364630)
- Testing
- Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU, Membrane Wrap-Lite™ DFU
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- BioLab Holdings
Diabetic Foot Ulcer (DFU), Diabetes Mellitus
DiaFootCare to Promote Self-Care of Diabetic Foot Ulcers in Oman
This study aims to evaluate DiaFootCare, a mobile health application designed to support self-care and monitoring among adults with diabetic foot ulcers.
- Trial name
- DiaFootCare (NCT07815275)
- Testing
- DiaFootCare Mobile Application, Usual Diabetic Foot Care
- Where
- Oman
- Volunteers
- 139 people
- Sponsor
- Oman Ministry of Health
Diabetic Foot Ulcer (DFU), Ulcer
Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Diabetic Foot Ulcers
To prospectively evaluate the safety and efficacy of an Autologous Platelet-Rich Fibrin Plasma system when applied in conjunction with Standard of Care for management of chronic Diabetic Foot Ulcers.
- Conditions
- Diabetic Foot Ulcer (DFU), Ulcer, Wound Closure, Wound Management
- Trial name
- NCT07840378
- Testing
- PRFM, Standard of Care (SoC)
- Volunteers
- 55 people
- Sponsor
- Tiger Biosciences, LLC.
Diabetic Foot Ulcers (DFU), Nutrition Assessment
Nutritional Status in Adults With Diabetic Foot Ulcers
This feasibility and pilot study has two aims. The primary aim is to assess the feasibility of collecting clinical, nutritional, and functional data among adults with diabetic foot ulcers (DFUs) who are treated at an outpatient…
- Conditions
- Diabetic Foot Ulcers (DFU), Nutrition Assessment, Malnutrition (Calorie), Ulcer Foot
- Trial name
- NutriDFU-P (NCT07621770)
- Testing
- Protein supplementation and nutrition education
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Diabetic Foot Ulcer (DFU), Lower Extremity
Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers
This study will evaluate Matrion™ (LifeNet Health, Inc., Virginia Beach, VA), a placental membrane product, as a treatment for diabetic foot ulcers compared to conventional wound care.
- Trial name
- NCT07116876
- Testing
- Graft Application, Wound Dressing Material
- Where
- 17 sites in United States
- Volunteers
- 120 people
- Sponsor
- LifeNet Health
Diabetic Foot Ulcer (DFU)
HPTC Versus AFSM in Diabetic Foot Ulcers
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers at multiple centres in India and Bangladesh.
- Trial name
- NCT07781917
- Testing
- High Purity Type-I Collagen-Based Skin Substitute and SOC, Acellular Intact Fish Skin Matrix and SOC
- Where
- 4 sites in Bangladesh, India
- Volunteers
- 120 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Diabetic Foot Ulcer (DFU)
A Study Comparing an Investigational Wound Gel With Standard Treatment for Mild to Moderate Diabetic Foot Ulcers
The goal of this clinical investigation is to evaluate if VES-0-D (an investigational wound gel) works to treat mild to moderate Diabetic Foot Ulcers.
- Trial name
- AIM-DFU (NCT07783087)
- Testing
- VES-0-D wound gel, Standard of Care (Investigator Choice)
- Where
- 8 sites in Belgium
- Volunteers
- 64 people
- Sponsor
- Flen Health
Diabetic Foot Ulcer (DFU)
CARE-D-FOOT-Nav Pilot
This pilot study aims to examine the implementation of a patient navigator intervention called Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation (CARE-D-Foot-Nav).
- Trial name
- NCT07143175
- Testing
- Comprehensive Assistance and Resources for Effective Diabetic Foot Navigation
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Diabetic Foot Ulcer (DFU), Granulation of Chronic Diabetic Wounds
Phase 1 Study of VELGRAFT, a Living Cellular Construct, in the Management of Chronic Diabetic Foot Ulcers Which Have Attained Granulation Tissue
The objective of this study is to evaluate the safety and efficacy of VELGRAFT in patients with chronic diabetic foot ulcers, which have attained granulation tissue.
- Trial name
- NCT07498218
- Testing
- an allogenic cell-based product, containing living human bone marrow-derived mesenchymal stem cells (MSCs) and MSCs differentiated into adipocytes on a porous chitosan-gelatin matrix, Standard of Care of Diabetic Foot Ulcers
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ayu, Inc.
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing
The retrospective trial is observational, intended to stand alone, complement and integrate data collected in ongoing clinical studies to aid in establishing payor coverage in the United States (U.S.) for Cellution Biologics…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
- Trial name
- RETRO-PLAST (NCT07375160)
- Testing
- dHPT, AIC
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cellution Biologics
Diabetic Foot Ulcer (DFU)
Controlled Trial to Evaluate the Safety and Efficacy of CYWC628 (Human Dermal Fibroblast Spheroids) for the Treatment of Refractory Diabetic Foot Ulcers Compared With Standard of Care
This is a prospective, multicentre, randomized clinical trial evaluating the safety, tolerability, and efficacy of up to 12 weeks treatment with SoC + low- or high-dose CYWC628 in treating DFU, compared to SoC only.
- Trial name
- NCT07096934
- Testing
- Standard of Care (SOC), SoC + Low dose CYWC628, SoC + High dose CYWC628
- Where
- 9 sites in Australia
- Volunteers
- 120 people
- Sponsor
- FibroBiologics
Diabetic Foot Ulcer (DFU), Palliative Care
The ProActive Study- Integrating a Proactive and Palliative Care Approach to Diabetic Ulcer Care
The ProActive study aims to investigate the feasibility of integrating a proactive palliative care approach into routine care for people with diabetic foot ulcers (DFU).
- Conditions
- Diabetic Foot Ulcer (DFU), Palliative Care, Advance Care Planning
- Trial name
- NCT07781111
- Volunteers
- 484 people
- Sponsor
- Ulla Riis Madsen
Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU)
The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.
Primary outcome: To evaluate the efficacy of L-Carnitine supplementation on length and depth ulcer size Secondary outcome: To investigate the effect of L-Carnitine supplements on: 1. Vascular endothelial growth factor (VEGF) 2.
- Trial name
- NCT07768228
- Testing
- L- carnitine
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Diabetic Foot Disease, Diabetic Foot Infection
Effect of a Coordinated Primary-care-Based MDT-model on the Treatment of Hard-to-heal Ulcers
The TSS project is a study of the effects of treating hard-to-heal ulcers in a multidisciplinary cross sectional team, meaning that nurse and doctor from a hospital based wound healing clinic and wound care nurse from the primary…
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Foot Ulcer (DFU), Ulcer
- Trial name
- TSS (NCT07747896)
- Testing
- coordinated primary-care-based MDT-model, Standard Care (in control arm)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Nordsjaellands Hospital
Wound, Foot, Diabetic Foot Ulcer (DFU)
CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs
CAMPR-II Trial: A multicenter hybrid platform trial comparing the effects of a prospective cohort treated with a saline-hydrated allogeneic dual-layer amniotic membrane product or a synthetic, resorbable polymeric wound matrix to…
- Conditions
- Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
- Trial name
- CAMPR-II (NCT07701590)
- Testing
- Microlyte®, IP 1: Membrane Wrap - Hydro
- Where
- 7 sites in United States
- Volunteers
- 147 people
- Sponsor
- Capsicure, LLC
Diabetic Foot Ulcer (DFU), Ocular Disorder
Air-Dried Human Amniotic Membrane Terminally Sterilized by Gamma Irradiation for Multidisciplinary Clinical Application
This prospective interventional clinical study aims to evaluate the safety and therapeutic efficacy of air-dried human amniotic membrane (hAM) sterilized using different doses of gamma irradiation for regenerative medical…
- Conditions
- Diabetic Foot Ulcer (DFU), Ocular Disorder, Pterygium
- Trial name
- GAMMA-AM (NCT07466576)
- Testing
- Air-Dried Human Amniotic Membrane (AD-hAM)
- Where
- Libya
- Volunteers
- 2 people
- Sponsor
- Libyan Center for Biotechnology Research
Diabetic Foot Ulcer, DFU
Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy
The goal of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers with multiple CAMPs plus SOC versus matched controls over 12 weeks…
- Conditions
- Diabetic Foot Ulcer, DFU, Diabetic Foot Ulcer (DFU), Foot Ulcer Due to Type 1 Diabetes Mellitus
- Trial name
- RENEW (NCT07086443)
- Testing
- Activate™ Matrix, AmnioDefend™ FT Matrix, Palisade™ DM Matrix
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Sequence LifeScience, Inc.
Diabetes Mellitus, Diabetic Foot Ulcer (DFU)
Risk Perception Intervention for High-Risk Diabetic Foot
This study aims to evaluate the effect of health education based on information framing effects on foot ulcer risk perception in patients at high risk of diabetic foot.
- Conditions
- Diabetes Mellitus, Diabetic Foot Ulcer (DFU), Risk Perception, Peripheral Neuropathy With Type 2 Diabetes
- Trial name
- NCT07581262
- Testing
- Gain-Framed, Loss-Framed, Routine Care
- Volunteers
- 90 people
- Sponsor
- The Third Affiliated Hospital of Soochow University