Clinical trials: Diabetes Mellitus, Type I
Diabetes Mellitus, Type 1, Hypertension
The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1
Nocturnal hypertension is recognized via ambulatory blood pressure monitoring in adolescents with type 1 diabetes mellitus. Melatonin, (as previously seen in earlier studies in adults), may alter these changes, which may be a…
- Trial name
- NCT02644590
- Testing
- Melatonin
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Insulin-Dependent Diabetes Mellitus
African-American Diabetes Intervention Project
A controlled trial to assess the potential benefit of a home based worker in improving control in African-American children with insulin dependent diabetes.
- Trial name
- NCT00006160
- Testing
- home based worker
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Evaluation of Glycemic Control and Quality of Life in Adults With Type 1 Diabetes During Continuous Glucose Monitoring When Switching to Insulin Glargine 300 U/mL
Retrospective multicenter study analyzing data gathered during the FUTURE study (S59342) to assess the effect of using Insulin Glargine 300 U/mL (Gla-300) on measures of diabetes control and quality of life.
- Trial name
- FUTURE-GLARE (NCT05109520)
- Testing
- Insulin Glargine 300 UNT/ML [Toujeo]
- Where
- 3 sites in Belgium
- Volunteers
- 867 people
- Sponsor
- prof dr Pieter Gillard
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 1
AT278 and NovoRapid® in Glucose Clamp Study
A phase 1, randomised, single-centre, double-blind, single-dose, two period balanced cross over study in a glucose clamp setting.
- Trial name
- NCT04660305
- Testing
- AT278, NovoRapid
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Arecor Limited
Type 1 Pediatric Diabetes
Description of the Evolution of a Cohort of Adolescents With Type 1 Diabetes Following Their Participation in Therapeutic Education Program Based on Social Cognitive Theory: Socio-cognitive Profile, Physiological Behaviour of Therapeutic Adherence and Quality of Life
Introduction: Therapeutic Patient Education (TPE) is the key of the interdisciplinary management of type 1 diabetes for adolescents, favoring their adherence and improving their quality of life and metabolic control.
- Trial name
- ETPACAP (NCT02859818)
- Testing
- therapeutic education program
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diabetes, Diabetes Mellitus, Type 1
Observational Study With Mixtard® 30 NovoLet® to Assess Patient Satisfaction
This study is conducted in Asia. The aim of this study is to assess patient satisfaction after switching to biphasic human insulin 30 treatment using the NovoLet® insulin device as treatment for diabetes mellitus under normal…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01492218
- Testing
- biphasic human insulin 30
- Where
- Philippines
- Volunteers
- 1,330 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Type 1 diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN07 (NCT00419562)
- Testing
- Oral Insulin
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 560 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1, Diabetic Nephropathy
Matrix Metalloproteinases and Diabetic Nephropathy
Matrix metalloproteinases (MMPs) are a family of protein-degrading enzymes that are involved in the breakdown and remodeling of many tissues and organs.
- Trial name
- NCT00067886
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Diabetes
Satisfaction of Specific Modes Related to Physical Activity in People Living With Type 1 Diabetes and Using an Hybrid Closed-loop System
The BF-ACT study is a single-center, non-interventional (RIPH3) descriptive study conducted at CHU Grenoble Alpes. It aims to evaluate the satisfaction of adults with type 1 diabetes using closed-loop insulin delivery systems…
- Trial name
- BF-ACT (NCT07567170)
- Testing
- Questionnar
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Grenoble
Peripheral Neuropathy, Type 1 Diabetes
Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
This 12 week study will examine the effects of daily Salsalate treatment on markers of neuropathic pain and intra-epidermal nerve fiber density.
- Trial name
- SALP (NCT01480297)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Diabetes Mellitus
A GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell Mass
The goal of the trial is to measure pancreatic uptake of 68Ga-NODAGA-exendin by PET/CT for detection of intra-individual differences in beta cell mass before and after treatment with Verapamil.
- Trial name
- Ver-A-image (NCT04615910)
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- 2 sites in Austria, France
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus
A Trial to Compare the PK and PD of Insulin Lispro Administered Into Different Tissues in Subjects With Diabetes Mellitus Type 1
The aim of this trial is to compare the pharmacokinetics and pharmacodynamics of insulin lispro injection into either lipohypertrophic lesions or normal tissue, utilizing both state-of-the-art euglycaemic clamp and mixed meal…
- Trial name
- NCT02221323
- Testing
- Insulin LISPRO
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Diabetes (Insulin-requiring, Type 1 or Type 2)
APP-MNT: App-Enhanced Medical Nutrition Therapy on Glycemic Outcomes and Quality of Life
The purpose of the study is to see if using a diabetes app along with nutrition counseling from a registered dietitian nutritionist can help improve blood sugars and cholesterol levels, quality of life, physical activity, and…
- Trial name
- App-MNT (NCT07773779)
- Testing
- Undermyfork Care App, Usual Care
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Weill Medical College of Cornell University
Type 1 Diabetes Mellitus
T1DM Immunotherapy Using Polyclonal Tregs + IL-2
The purpose of this study is to assess the safety of Tregs + IL-2 and survival of Tregs in patients with recent onset T1DM who receive infusions of autologous Tregs + IL-2.
- Trial name
- TILT (NCT02772679)
- Testing
- PolyTregs+IL-2
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Jeffrey Bluestone
Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes
The purpose of this study is to switch from insulin to oral sulfonylurea in patients with apparent type 1 diabetes or maturity onset diabetes in the young that are insulin treated.
- Conditions
- Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1, Childhood Diabetes Mellitus, Insulin-dependent Diabetes Mellitus
- Trial name
- SUtoChildT1D (NCT04239586)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital
Diabetes Mellitus
Study of Safety and Effectiveness of Apidra® in Combination With Basal Insulin in Patients With Type 1 & 2 Diabetes Mellitus
Primary Objectives: To determine the effect of insulin glulisine on glycemic control (HbA1c, FBG \& PPBG) from baseline to the end of the study.
- Trial name
- SCALE (NCT00526513)
- Testing
- Insulin Glulisine
- Where
- Egypt
- Volunteers
- 188 people
- Sponsor
- Sanofi
Type 1 Diabetes
The International Diabetes Closed Loop (iDCL) Trial: Protocol 4
The investigators aim to compare the efficacy and safety of an AID system using an adaptive MPC algorithm versus SAP (which may or may not include PLGS; to be referred to as SAP) in people with type 1 diabetes.
- Trial name
- DCLP4 (NCT04436796)
- Testing
- interoperable Artificial Pancreas System (iAPS), Sensor-Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sansum Diabetes Research Institute
Type 2 Diabetes
A Phase I Study of Polyethylene Glycol Loxenatide in Patients With Type 2 Diabetes
Polyethylene Glycol Loxenatide (PEX168) is a new human glucagon-like peptide 1 (GLP-1) analogue that created on the basis of the Exenatide and modified by polyethylene glycol (PEG).
- Trial name
- NCT01965496
- Testing
- PEX168
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Type 1 Diabetes, Type 2 Diabetes
Exercise and Diabetes - an Observational Study of Exercise and Blood Glucose Control
This proposal seeks to gather continuous blood glucose and physical activity data from individuals with and without diabetes.
- Trial name
- NCT02190669
- Testing
- exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.