Clinical trials: Diabetes Insipidus
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2, Arterial Hypertension
Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors
Subjects treated with Canagliflozin, Dapagliflozin and Empagliflozin obtained improvement on blood pressure values, body weight and cardiovascular mortality but pathophysiological explanations of these effects are not yet known.
- Conditions
- Diabetes Mellitus, Type 2, Arterial Hypertension, Body Weight Changes
- Trial name
- GliRACo1 (NCT03917758)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Diabetes Insipidus
Study of Novel Types of Familial Diabetes Insipidus
OBJECTIVES: I. Define the phenotype and genotype of previously unrecognized types of familial diabetes insipidus (FDI) in kindreds with atypical or novel forms of FDI.
- Trial name
- NCT00004364
- Testing
- desmopressin
- Volunteers
- 5 people
- Sponsor
- National Center for Research Resources (NCRR)
Heart Failure
Efficacy and Safety of Tolvaptan in Japanese Patients With Acute Heart Failure
The aims of the present study are to investigate prospectively the clinical course and outcome of the hospitalized heart failure patients treated with tolvaptan for management of fluid retention and serum sodium levels of less…
- Trial name
- MT FUJI (NCT01635517)
- Where
- Japan
- Volunteers
- 274 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Migraine
Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
There are still no reliable biomarkers for migraine; the diagnosis is based on symptomatology, and the pathogenesis remains largely a mystery.
- Trial name
- BioM (NCT07832032)
- Testing
- Rimegepant 75 MG
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Shock, Septic
Comparison of Vasopressin and Other Pressors in Septic Shock
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
- Trial name
- NCT00269685
- Testing
- vasopressin
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Obesity
Copeptin and Thirst: Possible Predictive Markers of Effectiveness of Bariatric Surgery?
Prospective, non-pharmacological, spontaneous, single-center, interventional study.
- Trial name
- NCT06806787
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure
The Correlation Between Filling Pressure, Cardiac Output and Plasma Copeptin in Patients With Systolic Heart Failure
The relationship between the activation of the vasopressin system and central hemodynamics in heart failure (including right and left heart filling pressures and cardiac output) is not clear.
- Trial name
- NCT01748006
- Testing
- Standard of care therapy for severe decompensated heart failure
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Finn Gustafsson
Colon Cancer Liver Metastasis, Inflammatory Response
Argipressin's Influence on Blood Loss During Hepatic Resection
Infusion of Argipressin during hepatic resection surgery may reduce blood loss. It may also reduce transfusion requirements, and mitigate the perioperative inflammatory response compared to placebo.
- Conditions
- Colon Cancer Liver Metastasis, Inflammatory Response, Vasopressin Causing Adverse Effects in Therapeutic Use
- Trial name
- ARG-01 (NCT05293041)
- Testing
- Argipressin
- Where
- Sweden
- Volunteers
- 248 people
- Sponsor
- Kristina Svennerholm
Cardiovascular Diseases, Heart Diseases
Pilot Study of Using Copeptin to Predict Response to Tolvaptan
This pilot study will investigate the association between levels of the peptide copeptin and response to tolvaptan, a drug that blocks the action of the water retaining hormone vasopressin.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure
- Trial name
- NCT01346072
- Testing
- tolvaptan
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Hyponatremia, Syndrome of Inappropriate Antidiuresis
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
- Trial name
- TREASUREx (NCT06821802)
- Testing
- Moltein PURE Protein Powder, Fluid restriction
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Endocrine System Diseases, Thyroid Diseases
Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
The aim of this study is to assess the impact of endocrine changes and their correction on survival and organ function in heart and lung transplant recipients.
- Conditions
- Endocrine System Diseases, Thyroid Diseases, Cortisol Deficiency, Diabetes Insipidus
- Trial name
- NCT04351945
- Testing
- Blood test
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Shock, Septic
Multimodal Vasopressor Strategy in Septic Shock
The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.
- Trial name
- NCT06155812
- Testing
- Simultaneous administration of vasopressors, Successive administration of vasopressors
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 79 people
- Sponsor
- University Medical Centre Maribor
Cirrhotic Patients With Ascites
Evaluation of Copeptin in Patients With Cirrhosis and Ascites
Copeptin is a glycopeptide released by the post-pituitary gland. In case of decrease in blood volume or blood pressure, it is secreted in the serum in an equimolar quantity to arginine vasopressin (AVP) .
- Trial name
- CIRCOPEP (NCT03318601)
- Testing
- Blood taking
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Decompensated Heart Failure
Impact of Therapy Optimization on the Level of Biomarkers in Patients With Decompensated Heart Failure
In this pilot, investigator-initiated multi-centre, multinational, observational study the investigators would like to examine the impact of therapy optimization on the level of biomarkers in patients with acute decompensated and…
- Trial name
- MOLITOR (NCT01501981)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Pituitary Surgery
Copeptin in the Diagnosis of Post-operative Insipidus Diabetes After Pituitary Surgery
Endoscopic trans-sphenoidal pituitary endoscopic surgery is one of the main axes of management of tumours of the sellar region. Central diabetes insipidus is a frequent complication of endoscopic trans-sphenoidal pituitary…
- Trial name
- Copeptin-surg (NCT04326569)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 57 people
- Sponsor
- CHU de Reims
Patients With Norepinephrine-refractory Vasoplegic Shock
Efficacy of Early Argipressin in the Management of Intensive Care Patients With Norepinephrine-refractory Vasoplegic Shock
Acute circulatory failure (shock) is defined as insufficient oxygen transport to meet the oxygen requirements of organs and tissues.
- Trial name
- Vaso²R (NCT07063680)
- Testing
- Argipressin, Chlorure de sodium, Collection of clinical data
- Where
- France
- Volunteers
- 390 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Septic Shock
Angiotensin II vs. Vasopressin in Septic Shock
This will be a randomized controlled unblinded pragmatic single-center pilot trial of the use of vasopressin vs. angiotensin II as a second-line vasopressor in patients with septic shock and persistent hypotension despite…
- Trial name
- NCT05193370
- Testing
- Angiotensin II, Vasopressin
- Where
- United States
- Sponsor
- University of New Mexico
Arginine Vasopressin Deficiency, Primary Polydipsia
Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which…
- Trial name
- COMPASS (NCT07569861)
- Testing
- Mannitol, Hypertonic Saline
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure
Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure Patients
The purpose of the present study is to evaluate the effects of a blockade of the vasopressin system and central hemodynamic system in heart failure (HF) patients during physical exercise.
- Trial name
- NCT01752543
- Testing
- Conivaptan
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Finn Gustafsson