Clinical trials: Detoxification
Prescription Opioid Dependence
Effective Treatment for Prescription Opioid Abuse
There has been an alarming increase in abuse of prescription opioids in recent years. This project aims to develop an effective outpatient treatment for prescription opioid (PO) abuse that combines an intensive behavioral therapy…
- Trial name
- NCT00719095
- Testing
- buprenorphine taper followed by naltrexone maintenance, Behavioral therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Vermont Medical Center
Opioid-Related Disorders
Buprenorphine Detoxification - BBDVI - 19
The purpose of this study is to examine the long-term efficacy of alternate-day dosing schedules in promoting treatment compliance in the absence of confounding behavioral contingencies.
- Trial name
- NCT00000237
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Addiction
Opiate Detoxification Using the Combined Hemoperfusion-hemodialysis
The purpose of this study is to determine whether combined hemoperfusion-hemodialysis treatment is an alternative drug-free, effective, and safe treatment for opiate detoxification.
- Trial name
- HPDMT (NCT01021566)
- Testing
- Combined hemoperfusion-hemodialysis, Methadone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First People's Hospital of Foshan
Alcohol Use Disorder
Ambulatory Alcohol Detoxification With Remote Monitoring
This study is designed to examine the feasibility and impact of the use of remote monitoring devices during an outpatient ambulatory alcohol detoxification treatment for patients with alcohol use disorders.
- Trial name
- NCT03582150
- Testing
- Remote Monitoring with Ambulatory Detox
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Alcoholism
Ketogenic Diet (KD) in Alcoholism
Background: A ketogenic diet (KD) is high in fat and low in carbohydrates. Research has shown that a KD can lessen tremor in animals withdrawing from alcohol.
- Trial name
- NCT03255031
- Testing
- Ketogenic Diet (KD), Standard American (SA) Meals and Shakes
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Heroin Dependence, Morphine Dependence
Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
The purpose of this study is to assess buprenorphine/naloxone versus clonidine for outpatient opiate detoxification.
- Conditions
- Heroin Dependence, Morphine Dependence, Substance Withdrawal Syndrome
- Trial name
- NCT00032968
- Testing
- Buprenorphine/naloxone
- Where
- 7 sites in United States
- Volunteers
- 341 people
- Sponsor
- University of California, Los Angeles
Shock, Septic
COMPACT - COMbining Plasma-filtration and Adsorption Clinical Trial
The study objective is to clarify whether the application of CPFA (coupled plasma-filtration adsorption) in addition to the current clinical practice is able to reduce mortality and prevent organ failures in septic shock patients…
- Trial name
- NCT00332371
- Testing
- CPFA (Coupled Plasma Filtration Adsorption)
- Where
- 19 sites in Italy
- Volunteers
- 184 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Inflammatory Bowel Diseases
Study of an Environmental Risk Factor in Crohn's Disease
Inflammatory bowel disease (IBD) are lifelong chronic diseases affecting the gastrointestinal tract. The precise etiology and the different actors participating to the pathophysiological process leading to the disease development…
- Trial name
- EVICTION (NCT04960826)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Drug Dependence, Drug Use Disorders
Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification
Methadone is a very long-acting opiate very difficult to detox from. In Spain there are a lot of methadone dependent people in the aftermath of the heroin epidemic of the 1980s.
- Conditions
- Drug Dependence, Drug Use Disorders, Opioid Dependence
- Trial name
- NCT04003948
- Testing
- Ibogaine Hydrochloride
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- International Center for Ethnobotanical Education, Research, and Service
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters
This phase II randomized, placebo-controlled trial evaluates whether daily supplementation with broccoli seed and sprout extract (BSSE), also known as Avmacol Extra Strength (ES), enhances the body's natural ability to detoxify…
- Conditions
- Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm, Occupational Malignant Neoplasm
- Trial name
- NCT06009926
- Testing
- Acetaminophen, Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Medication Overuse Headache
Is Detoxification Needed in Medication-overuse Headache?
Medication-overuse headache (MOH) is a disabling condition, yet treatable. According to European guidelines and based on evidence, multidisciplinary detoxification is the first choice of treatment for MOH.
- Trial name
- DEFINE3 (NCT02993289)
- Testing
- Different well-known treatments
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Alcohol Use Disorder
Psychosocial Intervention For Domiciliary Alcohol Detoxification
Alcohol Use Disorders (AUD) form a major public health issue in India. In a densely populated country with limited mental health resources, it is challenging to treat those with AUD appropriately.
- Trial name
- NCT05563740
- Testing
- Psychosocial
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Dr Sneha B Suresh
Celiac Disease
Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease
Oral supplementation with enzymes that can cut gluten has been suggested as a potential treatment modality for coeliac disease. In the present study the investigators wish to determine if co-administration of such an enzyme, a…
- Trial name
- NCT00810654
- Testing
- Aspergillus niger prolyl endoprotease
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Amsterdam UMC, location VUmc
Computer + Fluency, Computer Only
Evaluation of a Computerized Opioid Overdose Prevention Program
Unintentional fatal drug overdose (OD) is now the 2nd leading cause of accidental death in the general population. Fatal OD from opioid analgesics specifically has increased over 400% between 1999 and 2008, and nonfatal overdose…
- Conditions
- Computer + Fluency, Computer Only, Treatment as Usual
- Trial name
- NCT02040077
- Testing
- Computer + Fluency, Computer Only, Treatment as Usual
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Johns Hopkins University
Alcohol Dependence
ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults
This was a study of the effects of VIVITROL® on alcohol cue-induced craving and the associated brain activation patterns in alcohol-dependent adults who had recently completed alcohol detoxification and were seeking further…
- Trial name
- NCT00511836
- Testing
- VIVITROL 380 mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Alkermes, Inc.
Alcoholism
Simultaneous Measurement of Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) in Patients With Alcoholism
Investigation of inpatients with alcoholism after detoxification with simultaneous Electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI).
- Trial name
- NCT00216905
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Opiate Dependence
Acceptance Therapy During Methadone Detoxification
The purpose of this study is to develop an opiate detoxification behavior therapy based on current Acceptance and Commitment Therapy (ACT) theory and method, and to test its feasibility and promise in the context of voluntary…
- Trial name
- NCT00439036
- Testing
- Behavior Therapy, Drug Counseling
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid Withdrawal, Opioid Use Disorder
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
The primary objective of this trial is to measure changes in physiologic signals to quantify the status of the autonomic nervous system during opioid withdrawal and cravings.
- Trial name
- NCT06487533
- Testing
- EmbracePlus Smartwatch, Corti Sensor
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Spark Biomedical, Inc.
Hyperthermia
Complementary and Alternative Medicine Sauna Detoxification Study: Phase I
The purpose of this study is to determine the impact of sauna use on polychlorinated biphenyls (PCB) in the blood of healthy human adults, as well as to assess safety, feasibility, and tolerability, and effects on quality of life…
- Trial name
- NCT01905098
- Testing
- Sauna Detoxification Protocol, Observation Sessions
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Psychiatry
NUTRItion-driven Detoxification of OPioid Addicted patiEnts
The NUTRIDOPE (NUTRItion-driven Detoxification of OPioid addicted patiEnts) study is a clinical trial that aims to investigate the role of pomegranate juice consumption by opioid-addicted patients under buprenorphine and…
- Trial name
- NUTRIDOPE (NCT05861544)
- Testing
- Pomegranate juice
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- Organization Against Drugs (ΟΚΑΝΑ)