Clinical trials: Dermal Regeneration
Horizontal Ridge Deficiency
Implant Phenotype Modification Via GBR and ADM
Single implant sites with bone loss can often be managed by bone grafting alone. The purpose of this study is to determine whether putting a soft tissue graft substitute over the bone graft will provide an increased benefit for…
- Trial name
- NCT07082244
- Testing
- Dental implant placement, Guided bone regeneration with collagen membrane, Guided bone regeneration with acellular dermal matrix.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Breast Reconstruction After Mastectomy, Neurotization
Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components
This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women…
- Conditions
- Breast Reconstruction After Mastectomy, Neurotization, Mastectomy and Breast Reconstruction, Peripheral Nerve Regeneration
- Trial name
- NCT07308275
- Testing
- Autologous Breast Reconstruction With Direct Neurotization, Autologous Breast Reconstruction without Neurotization
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Dermal Regeneration
Dermogenesis With Mesenchymal Stem Cells
Dermogenesis With Mesenchymal Stem Cells in treating Post Acne Depressed Spots
- Trial name
- MSCs (NCT06135519)
- Testing
- Autologous Mesenchymal stem cells injection, Homogenized fat injection
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Periodontitis, Periodontitis (Stage 3)
Morphological Characteristics of Mandibular Molar Furcation Involvement and Efficacy of Regenerative Surgical Treatment
This study consists of two components evaluating furcation involvement in mandibular molars among Stage III or Stage IV periodontitis patients.
- Conditions
- Periodontitis, Periodontitis (Stage 3), Furcation Defects
- Trial name
- NCT07770256
- Testing
- Acellular Dermal Matrix + EMD + Xenograft, Autogenous Connective Tissue Graft + EMD + Xenograft
- Where
- Vietnam
- Volunteers
- 98 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Cronic Full-thinkness Skin Wound, Acute Full-thickness Skin Wound
Efficacy of a Photosynthetic Dermal Matrix for the Treatment of Full-Thickness Skin Wounds
The goal of this clinical trial is to evaluate whether the incorporation of photosynthetic microalgae into scaffolds for dermal regeneration improves healing outcomes in adult patients with acute and cronic full-thickness skin…
- Trial name
- NCT07157657
- Testing
- Surgical implantation with standard (DRM) or photosynthetic dermal regeneration matrices (PDRM) in same patient., Autologous split-thickness skin grafting over implanted matrices
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Wound Care, Pressure Ulcer
Direct Application of Integra Bilayer Matrices on Bare Calvarium Without Preliminary Burring
This study is to determine if large, full thickness scalp wounds with exposed calvarium resulting from acutely created extirpative defects can be reliably and durably resurfaced with IDRT without burring or fenestration as a…
- Conditions
- Wound Care, Pressure Ulcer, Venous Ulcer, Surgical Wound
- Trial name
- NCT05311124
- Testing
- Integra Dermal Regeneration template (IDRT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Joshua Choo
Neuropathic Diabetic Ulcer - Foot
A Safety and Efficacy Study of INTEGRA® Dermal Regeneration Template for the Treatment of Diabetic Foot Ulcers
The objective of this study is to evaluate the safety and efficacy of the INTEGRA® Dermal Regeneration Template for the treatment of diabetic foot ulcers located distal to the malleolus in subjects with diabetes mellitus…
- Trial name
- NCT01060670
- Testing
- Integra® Dermal Regeneration Template, Conventional Wound Therapy
- Where
- 33 sites in United States, Netherlands Antilles
- Volunteers
- 545 people
- Sponsor
- Integra LifeSciences Corporation
Dental Surgery
Evaluation of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Dental Surgery
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Dental membrane used in dental surgery and to identify emerging risks in comparison to clinical data related to…
- Trial name
- NCT05435976
- Testing
- CELLIS Dental (Porcine Acellular Dermal Matrix, PADM)
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- Meccellis Biotech
Burn, Thermal
StrataGraft® Skin Tissue in the Promotion of Autologous Skin Regeneration of Complex Skin Defects Due to Thermal Burns That Contain Intact Dermal Elements
About 70 participants will be enrolled. They will have complex skin defects because of burns caused by heat. The burns will: be on 3-49% of the participant's total body surface area (TBSA) require surgery for skin replacement…
- Trial name
- NCT03005106
- Testing
- StrataGraft Skin Tissue, Autograft
- Where
- 16 sites in United States
- Volunteers
- 71 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds
LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults
This research study is investigating a new topical medication called LUT017, which is being developed to help heal chronic skin wounds, particularly those known as venous leg ulcers (VLUs).
- Conditions
- Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds, VLU
- Trial name
- NCT07463365
- Testing
- LUT017 gel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Antoni Ribas
Diabetes Type I, Diabetes Type II
Feasibility Study of DermGEN for Diabetic Foot Ulcer Treatment
The purpose of this clinical trial is to perform a limited pilot study to determine the safety and feasibility of DermGEN in the treatment of non-healing diabetic foot ulcers (DFU). This will be a one-arm prospective study.
- Trial name
- NCT02184455
- Testing
- DermGEN
- Where
- 2 sites in Canada
- Volunteers
- 11 people
- Sponsor
- Dr. Paul F. Gratzer
Skin Manifestations
New Regenerative Approach for Dermal Renovation (Karisma)
Purpose/Objectives of the Study: Regenerative medicine, as well as aesthetic plastic surgery and dermatology field persistently seeks innovative, minimally invasive interventions to enhance skin quality and mitigate signs of…
- Trial name
- Karisma (NCT06152718)
- Testing
- Karisma
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Bone Atrophy, Alveolar, Bone Loss
Tunnel Access for Horizontal Alveolar Ridge Augmentation
Minimally invasive procedures with the tunnel technique have been suggested to decrease patient post-operative discomfort and morbidity in oral bone regeneration.
- Conditions
- Bone Atrophy, Alveolar, Bone Loss, Bone Resorption, Alveolar Bone Loss
- Trial name
- NCT06424223
- Testing
- Horizontal Ridge augmentation
- Where
- Italy
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Skin Regeneration
Skin Dermal Regeneration After Stromal Vascular Fraction Transplantation
This study is a prospective, exploratory investigation aimed at exploring the efficacy of stromal vascular fraction (SVF) transplantation in treating exhaustion of dermal regenerative capacity during skin expansion.
- Trial name
- SDR-SVF (NCT06439459)
- Testing
- Stromal vascular fraction transplantation
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Skin Wound
Dermal Regeneration Photosynthetic Matrix
The aim of the study is to demonstrate that dermal regeneration photosynthetic matrix applied in patients with acute clean skin wound is safe.
- Trial name
- HULK (NCT03960164)
- Testing
- Dermal regeneration photosynthetic matrix (DRPM)
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Burns, Full Thickness Burn
A Single-stage Bilayered Skin Reconstruction With Glyaderm®
The study will explore the potential of utilizing Glyaderm® in a single-stage engrafting process, aiming for a more cost-effective approach.
- Conditions
- Burns, Full Thickness Burn, Necrotizing Fascitis
- Trial name
- NCT06249971
- Testing
- Dermal subsitute Glyaderm + skin graft, Skin graft alone
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- University Hospital, Ghent
Androgenetic Alopecia
Study of EPI-001 in Patients With Androgenetic Alopecia
This is a Phase I/IIa clinical study to evaluate the safety, tolerability, and preliminary efficacy of EPI-001 in patients with androgenetic alopecia.
- Trial name
- NCT07618195
- Testing
- EPI-001
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Epibiotech
Diabetic Foot Ulcers (DFUs), Diabetic Foot
Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers
This study is designed to evaluate whether the Miro3D Wound Matrix, when used in addition to standard of care, improves healing outcomes in patients with chronic diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcers (DFUs), Diabetic Foot, Chronic Wounds
- Trial name
- FOCUS 3D (NCT07632001)
- Testing
- Miro3D Wound Matrix, Standard of Care
- Where
- 14 sites in United States
- Volunteers
- 180 people
- Sponsor
- Reprise Biomedical, Inc.
Augmentation, Reconstruction
Dermal and Subcutaneous Augmentation and Skin Assessment After Fat-, Stem Cell and Scaffold Injections
Investigate the effect of dermal/subcutaneous injection of ASC enriched fat transplant in a protective natural scaffold, designed to sustain the ASC viability after dermal/subcutaneous injection.
- Trial name
- NCT05079243
- Testing
- Scaffold and adipose-derived stromal cell enriched fat grafts
- Where
- 2 sites in Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stemform