Clinical trials: Depression and Suicide
Bipolar Disorder (BD), Suicidality
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Bipolar disorder is characterized by manic episodes and episodes of extreme depressive feelings, also known as bipolar depression (BD).
- Trial name
- DEEPP (NCT05177146)
- Testing
- Intravenous Ketamine (IV)
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Depression and Suicide Ideation, Anxiety
Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence
This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high…
- Conditions
- Depression and Suicide Ideation, Anxiety, PTSD
- Trial name
- NCT06980441
- Testing
- Problem Management Plus with Emotional Processing module
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Peace of Mind Association (PoMA)
Depression, Depression Moderate
Outcomes Associated With Suicidality in Inpatients With Symptoms of Depression (OASIS-D)
This 6-month, naturalistic cohort study examines male and female inpatients aged 18 to 75 years i) with any form of unipolar depressive episode (cohort 1); ii) clinical diagnosis of a moderate or severe unipolar depressive…
- Conditions
- Depression, Depression Moderate, Depression Severe, Suicidal and Self-injurious Behavior
- Trial name
- OASIS-D (NCT04404309)
- Where
- Germany
- Volunteers
- 3,331 people
- Sponsor
- Charite University, Berlin, Germany
Depression, Mental Disorder in Adolescence
Study of Web- Based Cognitive Behavioral Therapy for Depressed Korean Adolescents
The purpose of this study is to develope web-based cognitive behavioral therapy for Korean adoldescents who have a mild depression.
- Conditions
- Depression, Mental Disorder in Adolescence, Cognitive Behavioral Therapy
- Trial name
- wogyeokdajim (NCT02072304)
- Testing
- web-based CBT, supportive care
- Where
- 3 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Hallym University Medical Center
Interpersonal Trauma, Depression
The BEAR Program for Women With Trauma Who Have Suicidal Thoughts
The current study aims to test the feasibility of a new form of group therapy for women who have a history of interpersonal trauma and current suicidal ideation.
- Conditions
- Interpersonal Trauma, Depression, PTSD, Anxiety
- Trial name
- BEAR-SI (NCT07346638)
- Testing
- BEAR-SI
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Anxiety Disorders, Depression
Pharmacogenomics of Antidepressant Response in Children and Adolescents
This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications.
- Conditions
- Anxiety Disorders, Depression, Eating Disorders, Obsessive-Compulsive Disorder
- Trial name
- PARCA (NCT00516932)
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Duke University
Depression, Suicide
Intranasal Ketamine for Late-Life Depression and Suicidal Ideation
The investigators of this study plan to investigate the feasibility and efficacy of repeated doses of intranasal ketamine in severely depressed patients who are at least 65 years of age and experiencing suicidal ideation.
- Conditions
- Depression, Suicide, Suicidal Ideation
- Trial name
- NCT02295787
- Testing
- Ketamine
- Sponsor
- Massachusetts General Hospital
Suicidal Behavior, Self-Harm, Deliberate
Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
This randomized controlled trial will evaluate two approaches to achieving the aspirational goal of Zero Suicide within a health system: 1) Zero Suicide Best Practices initiated through a zero suicide quality improvement…
- Conditions
- Suicidal Behavior, Self-Harm, Deliberate, Suicidal Ideation, Suicide
- Trial name
- Step2Health (NCT03092271)
- Testing
- Stepped Care for Suicide Prevention, Zero Suicide Quality Improvement
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- University of California, Los Angeles
Suicidal Ideation, Suicide Attempt
Teen Recovery Through Inspiration, Support, and Empowerment
The goal of this pilot study is to test the effectiveness of a novel intervention for teenagers (ages 15-18) with mental health conditions who have been released from an acute care psychiatric facility.
- Conditions
- Suicidal Ideation, Suicide Attempt, Anxiety, Depression Disorders
- Trial name
- Teen RISE (NCT07170657)
- Testing
- Peer Support Services Recovery
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Suicidal Ideation, Suicidal and Self-injurious Behavior
Optimizing Suicide Prevention Strategies for Pediatric Primary Care
Increasing rates of suicidal thoughts and behaviors among adolescents must be addressed. The study will adapt and collect preliminary effectiveness data on a digital suicide prevention intervention that can be delivered in…
- Conditions
- Suicidal Ideation, Suicidal and Self-injurious Behavior, Depression
- Trial name
- NCT06194331
- Testing
- iCHART/cASAP, Treatment as usual
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Suicide Ideation, Suicidal Intention
Classification and Assessment of Mental Health Performance Using Schematics
This is an open enrollment study to collect data for the optimization of smartphone-based algorithms for the early detection of mental health and suicidal risk in a student population.
- Conditions
- Suicide Ideation, Suicidal Intention, Suicide and Depression
- Trial name
- CAMPUS (NCT04275908)
- Testing
- MHSAFE app
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clarigent Health
Major Depressive Disorder
Lithium Versus Paroxetine in Major Depression
This study is being done to look at how well people respond to two different drug treatments for depression. Clinically, people can respond differently to different treatments for reasons which are not always clear.
- Trial name
- NCT01416220
- Testing
- Lithium, Paroxetine
- Where
- Canada
- Sponsor
- Nova Scotia Health Authority
Depression, Anxiety
Mobile Mental Health Apps for Suicide Prevention
Access to mental health care by essential workers and the unemployed during the COVID19 pandemic has been challenging. Usual access to mental health care is limited by social distancing, and for many now unemployed due to…
- Conditions
- Depression, Anxiety, Emotional Regulation
- Trial name
- NCT04536935
- Testing
- Mobile Mental Health App - 1, Mobile Mental Health App - 2, Mobile Mental Health App - 3
- Where
- United States
- Volunteers
- 838 people
- Sponsor
- University of Washington
Depression
Lithium and Standard Therapy in Resistant Depression
The principal clinical question is whether lithium is effective in reducing the risk of suicidal behaviour in subjects with treatment-resistant depression and suicide risk.
- Trial name
- LAST (NCT00927550)
- Testing
- lithium, usual care
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- Universita di Verona
Bipolar Depression, Suicidal Ideation and Behavior
NRX-101 for Bipolar Depression With Subacute Suicidal Ideation
NMDA antagonist drugs have shown to reduce symptoms of depression and suicidal ideation. NeuroRx has developed NRX-101 (fixed dose combination of D-cycloserine and lurasidone) for oral use in the treatment of bipolar depression…
- Trial name
- NCT03395392
- Testing
- NRX-101, Lurasidone HCl
- Where
- 14 sites in United States
- Volunteers
- 74 people
- Sponsor
- NeuroRx, Inc.
Major Depressive Disorder, Bipolar Disorder
Naturalistic Study of Ketamine in the Treatment of Depression
This study aims to examine the effect of ketamine in decreasing the risk of suicide in patients with depression and its effectiveness as an antidepressant agent.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Bipolar I Disorder
- Trial name
- NCT05249309
- Testing
- Ketamine
- Where
- 2 sites in Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
The goal of this clinical trial is to learn if intravenous (IV) ketamine with Dialectical Behavioural Therapy (DBT) reduces suicidal ideation in individuals with suicidality who have been diagnosed with Borderline Personality…
- Conditions
- Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder, Treatment-resistant Bipolar Depression, Major Depressive Disorder (MDD)
- Trial name
- KET-DBT (NCT07569198)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Joshua Rosenblat
Suicidal Ideation
Stratified-Care School-Based Intervention for Adolescent Suicidal Ideation
Background. Suicidal ideation and depressive symptoms are highly prevalent among adolescents, with suicide representing a leading cause of death in this age group worldwide.
- Trial name
- NCT07063914
- Testing
- Reframe-IT and CARIBOU
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad de los Andes, Chile
Suicide, Depression
Inflammation and Blood Brain Barrier Integrity as Biomarkers of Suicidal Behavior
Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma.
- Trial name
- IBBBiS (NCT06047613)
- Testing
- Blood samples, Hetero-questionnaires and auto-questionnaires, Magnetic Resonance Imaging (MRI)
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bipolar Depression, Suicidal Ideation
NRX101 Glx Biomarker Validation Study
Subnormal level of Glutamate+Glutamine (Glx) in the Anterior Cingulate Cortex (ACC) of the brain has been associated with depression and PTSD.
- Trial name
- NRX-GLX (NCT03402152)
- Testing
- NRX-101, Lurasidone HCl
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- NeuroRx, Inc.