Clinical trials: Depression, Involutional
Depression, Involutional
Function of Catecholamines in the Brain During Depression
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain…
- Trial name
- NCT00082030
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Involutional Depression, Anxiety Disorders
MRI Study of Brain Activity and Risk for Depression in Adolescents
Anxiety in children of parents with major depressive disorder (MDD) poses a particularly high risk for later-life MDD. In adults, MDD involves dysfunction in prefrontal brain regions that regulate attention to emotional stimuli.
- Trial name
- NCT00047944
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Study Evaluating DVS-233 in Adult Outpatients With Major Depressive Disorder
Primary: To compare the antidepressant efficacy and safety of subjects receiving DVS-233 SR versus subjects receiving placebo. Secondary: To assess the response of subjects receiving DVS-233 SR for the clinical global evaluation…
- Trial name
- NCT00063206
- Testing
- DVS-233 SR
- Volunteers
- 247 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Bone Diseases, Metabolic, Depression, Involutional
Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression
In this study researchers would like to learn more about the low levels of bone mineral density seen in approximately half of women in their forties diagnosed as currently having or previously had depression.
- Conditions
- Bone Diseases, Metabolic, Depression, Involutional, Osteoporosis
- Trial name
- NCT00001916
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Involutional, Major Depresssion
Rapid Antidepressant Effects of Yohimbine in Major Depression
This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours.
- Trial name
- NCT00078715
- Testing
- Yohimbine hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Mental Health (NIMH)
Adrenal Gland Hyperfunction, Cardiovascular Disease
Heart Disease Risk Factors in Major Depression
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide.
- Conditions
- Adrenal Gland Hyperfunction, Cardiovascular Disease, Involutional Depression
- Trial name
- NCT00001969
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness and safety of vortioxetine, once daily (QD), in patients with Major Depressive Disorder.
- Trial name
- NCT00735709
- Testing
- Vortioxetine
- Where
- 48 sites in Australia, Czechia and 13 more
- Volunteers
- 560 people
- Sponsor
- Takeda
Bipolar Disorder, Involutional Depression
Study of the Psychological Development of Children of Parents With and Without Affective Disorders
This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to…
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001170
- Where
- United States
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Involutional Depression
Bone Mineral Density in Women With Major Depression
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than…
- Conditions
- Healthy, Involutional Depression, Osteoporosis
- Trial name
- NCT00001413
- Where
- United States
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
To compare the antidepressant efficacy and safety of subjects receiving DVS-233 SR versus subjects receiving placebo.
- Trial name
- NCT00072774
- Testing
- DVS-233 SR
- Volunteers
- 480 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Depression, Involutional, Healthy
Serotonin Function During Depression
Serotonin is a chemical involved in regulation of emotions, anxiety, sleep, stress hormones, and other body functions. The purpose of this study is to use a procedure called tryptophan depletion to study the function of serotonin…
- Trial name
- NCT00033787
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Involutional Depression
Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial
This study will examine the effectiveness of omega-3 fatty acids, compounds found in plants and fish, in treating bipolar disorder. Some studies have indicated that omega-3 fatty acids may be effective in treating mood disorders.
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001146
- Testing
- Ethyl Eicosapentaenoic Acid, OmegaBrite
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Involutional
Neurocardiac Control in Major Depression
This study will examine how depression may influence the way the brain regulates heart function. Some researchers believe that depression may be a risk factor for some forms of heart disease.
- Trial name
- NCT00084162
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy, Involutional Depression
Dynamics of Leptin and Endocrine Function
This is a study investigating the hormones and substances important to the stress response. The hormone that is most directly responsible for stress response is called corticotropin-releasing hormone (CRH).
- Trial name
- NCT00001543
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)