Clinical trials: Depressed
Major Depressive Disorder, Suicide
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
Approximately four thousand Canadians die by suicide every year, and suicide is the second leading cause of death in youth and young adults (15-34 years).
- Conditions
- Major Depressive Disorder, Suicide, Treatment Resistant Depression
- Trial name
- Ket-CBT (NCT06480500)
- Testing
- Ketamine hydrochloride, i-CBT (Internet-based Cognitive Behavioural Therapy), Midazolam Hydrochloride
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- University Health Network, Toronto
Low Back Pain, Depression
Cipralex in Treatment of Depressive Symptoms and Chronic Back Pain
Chronic low back pain (CLBP) is one of the most frequent forms of chronic pain and can result in significant functional impairment. This is often associated with major depression too.
- Trial name
- NCT00227292
- Testing
- Escitalopram
- Where
- Germany
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Metabolic Syndrome, Obesity
Low-intensity Exercise in Metabolic Syndrome
People with metabolic syndrome (MetS) are characterized by a lower quality of life in terms of reduced vital activity, emotional state, and social functioning.
- Conditions
- Metabolic Syndrome, Obesity, Hypertension, Hyperlipidemias
- Trial name
- NCT04346836
- Testing
- Low-intensity, general-fitness exercises, Psychoeducation
- Where
- Poland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Bipolar Depression
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression
The purpose of the study is to determine the efficacy, safety and pharmacokinetics of inhaled Esketamine in participants with treatment-resistant bipolar depression (TRBD).
- Trial name
- NCT03965871
- Testing
- Esketamine DPI - low dose, Esketamine DPI - medium dose, Esketamine DPI - high dose
- Where
- 12 sites in Poland
- Volunteers
- 88 people
- Sponsor
- Celon Pharma SA
Anxiety, Depression
Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers
This study is being done to test the effects of Managing Anxiety from Cancer (MAC) therapy on anxiety compared to usual care, in patients and their caregivers.
- Conditions
- Anxiety, Depression, Quality of Life
- Trial name
- NCT03168971
- Testing
- Managing Anxiety from Cancer (MAC)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Patient Depression, Anxiety, Stress and Pain
The Effect of Listening to Holy Quran Recital on Depression, Anxiety and Stress Post CABG
Coronary artery bypass graft (CABG) is one of the most common surgical treatments for coronary artery disease. CABG has many beneficial outcomes for patients.
- Trial name
- NCT05419544
- Testing
- Holy Quran Recital effect
- Where
- 2 sites in Jordan
- Volunteers
- 128 people
- Sponsor
- Applied Science Private University
COPD, Anxiety
Registry for Chronic Obstructive Pulmonary Disease With Anxiety and Depression in China
Anxiety and depression are common comorbidities of chronic obstructive pulmonary disease (COPD). However, the exact prevalence is not known in China.
- Conditions
- COPD, Anxiety, Depression
- Trial name
- NCT03187236
- Where
- China
- Volunteers
- 1,906 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Bipolar Disorder
Olanzapine/Fluoxetine Combination Versus Comparator in the Treatment of Bipolar I Depression
The purpose of this study is to assess olanzapine/fluoxetine combination and lamotrigine comparative efficacy, safety and tolerability in acute and longer term treatment of bipolar depression.
- Trial name
- NCT00485771
- Testing
- Olanzapine, Fluoxetine, Lamotrigine
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder, Mania
Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study
The purpose of this study is to determine whether the amino acid taurine has effects on mood stability in bipolar disorder.
- Conditions
- Bipolar Disorder, Mania, Bipolar Depression
- Trial name
- NCT00217165
- Testing
- taurine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mclean Hospital
Major Depression, Major Depression Disorders
Accelerated High-Dose tDCS for Depression
In this study, investigators are testing whether a higher dose of a non-invasive brain stimulation technique, called transcranial direct current stimulation (tDCS), can be safely used in people with depression.
- Trial name
- NCT07226011
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease, Obsessive-Compulsive Disorder
Electrophysiology of Brain Activity During Electrode Implantation in Patients Treated With Deep Brain Stimulation
Primary objective Demonstrate functional markers derived from electrophysiological signals recorded during cognitive tests. These markers should make it possible to optimize the targeting procedures of electrode implantation…
- Conditions
- Parkinson Disease, Obsessive-Compulsive Disorder, Epilepsy, Depression
- Trial name
- LFP-DBS (NCT03874611)
- Testing
- electrophysiological data from DBS
- Where
- France
- Volunteers
- 125 people
- Sponsor
- University Hospital, Grenoble
Depression, Non-psychotic Diagnosis as Co-morbidity
The Canadian Armed Forces PEER Study
This is a prospective, single-blinded, randomized, multicenter study to evaluate the utility, safety, and efficacy of using PEER Interactive - an EEG-based technology - to inform the prescription of medications to participants…
- Trial name
- PEERCanada (NCT03625271)
- Testing
- The PEER Report
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- MYnd Analytics
Malignant Tumor, Anxiety
Long-term Follow-up of Anxiety and Depression in Patients With Malignant Tumors
This study was a single-center prospective, real-world observational study with plans to enroll all eligible patients. The basic information, anxiety and depression, treatment and prognosis of these patients were collected.
- Conditions
- Malignant Tumor, Anxiety, Depression
- Trial name
- NCT05596344
- Testing
- Hospital Anxiety and Depression Scale
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Henan Cancer Hospital
Depression
A Study of the Use of IV Scopolamine to Augment the Efficacy of Electroconvulsive Therapy (ECT)
The primary purpose of this study is to assess the ability of scopolamine to improve the antidepressant effects of ECT and to determine whether scopolamine will shorten the time to response and remission for patients receiving…
- Trial name
- NCT01312844
- Testing
- Scopolamine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Quality of Life (QOL), Mental Wellbeing
Arts for Wellness (AFW): Arts-Based Social Prescribing During Inpatient Rehabilitation for Older Adults in Singapore
This mixed-methods study examined whether Arts for Wellness (AFW), an artist-led arts programme introduced during inpatient rehabilitation, improves mental wellbeing among older adults in a Singapore community hospital, and…
- Conditions
- Quality of Life (QOL), Mental Wellbeing, Anxiety, Depression
- Trial name
- SPNAC (NCT07851467)
- Testing
- Arts for Wellness - Dance, Arts for Wellness - Literary arts
- Where
- Singapore
- Volunteers
- 288 people
- Sponsor
- SingHealth Community Hospitals
Irritable Bowel Syndrome, Quality of Life
Effect of Stress Ball on Irritable Bowel Syndrome
Objective: This study will be conducted to evaluate the effect of stress ball on symptom severity, quality of life, depression, anxiety and stress in patients with irritable bowel syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome, Quality of Life, Depression, Anxiety
- Trial name
- NCT05931107
- Testing
- Stress ball practice group (Stress ball squeezing)
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Bedriye Cansu DEMİRKIRAN
Dementia of Alzheimer Type, Dementia Frontotemporal
Multifactorial Approach to Dementia, Multicentric Study
The goal of this observational study is to assess the role of narcisistic personality disorder and life stressful events in conversion rate to dementia, using a three tier approach along three research lines employing subjects…
- Conditions
- Dementia of Alzheimer Type, Dementia Frontotemporal, Narcissistic Personality Disorder, Depression
- Trial name
- NCT05923307
- Where
- Argentina
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Daniel Serrani Azcurra
Depression, Unipolar, Depression, Bipolar
IM Ketamine vs Midazolam for Suicidal ER Patients
Rising US suicide rates and the increased risk of suicide among persons who visit an emergency department (ED) for suicidality make the ED an important site for interventions to prevent suicide.
- Conditions
- Depression, Unipolar, Depression, Bipolar, Suicidal Ideation
- Trial name
- NCT04640636
- Testing
- Ketamine hydrochloride injection, Midazolam injection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- New York State Psychiatric Institute
Depression, Anxiety
The Effects of Wild Blueberries on Depressive Symptoms in Young Adults
This study aims to investigate the effects of a 6-week dietary intervention of 22 g freeze-dried whole wild blueberry powder. The outcomes include measures of depression, anxiety, anhedonia, cognitive function, and biomarkers of…
- Conditions
- Depression, Anxiety, Anhedonia
- Trial name
- BluMood (NCT04647019)
- Testing
- Wild blueberry powder
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- University of Reading
Depression
Designing and Testing a Family Therapy for Adolescent Depression
This study will design and test a cognitive behavioral therapy for depressed adolescents that uses family interactions to help with treatment.
- Trial name
- NCT00867919
- Testing
- Behavioral Family Treatment, Community-based treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Oregon Research Institute
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